Last Updated on December 2, 2025 by Bilal Hasdemir
Anorectal conditions affect millions of people worldwide, making their lives harder. Studies show these conditions are more common than thought. Many people seek medical help for these issues.
Anorectal surgery includes many procedures for the anorectal area. These are done by a proctology specialist or a colorectal surgeon.
Knowing about colorectal surgery and its procedures is key. It helps in treating and managing anorectal diseases.
Key Takeaways
- Anorectal conditions are common and can significantly impact quality of life.
- Anorectal surgery includes various procedures to treat anorectal conditions.
- A proctology specialist or colorectal surgeon typically performs these surgeries.
- Understanding the range of surgical options is important for effective treatment.
- Colorectal surgery is a critical aspect of treating anorectal diseases.
Defining Anorectal Surgery
Anorectal surgery is about fixing problems in the anorectal area. This area includes the anal canal and rectum. It’s a special surgery field that helps with many issues.
The Scope and Purpose of Anorectal Procedures
Anorectal surgery treats many issues like hemorrhoids and anal fissures. The main goal is to make patients feel better and live better lives.
Some common types of anorectal surgery include:
- Hemorrhoidectomy
- Fistulotomy and Fistulectomy
- Lateral Internal Sphincterotomy
- Rectal Prolapse Repair
Procedure | Purpose | Common Conditions Treated |
Hemorrhoidectomy | Removal of hemorrhoids | Prolapsed, thrombosed, or bleeding hemorrhoids |
Fistulotomy/Fistulectomy | Treatment of anal fistulas | Anal fistulas, recurrent fistulas |
Lateral Internal Sphincterotomy | Relief of anal sphincter spasm | Chronic anal fissures |
Anatomical Considerations of the Anorectal Region
Knowing the anorectal area’s anatomy is key for surgery. The area includes the anal canal, rectum, and more.
The anal canal is complex with a lot of blood and nerves. This makes surgery there tricky. The rectum is connected to the colon and helps with bowel movements.
Surgery in this area is designed for each specific problem. Surgeons must balance keeping things working right while fixing issues. This is true for anal canal surgery and rectal surgery.
Common Conditions Requiring Anorectal Surgery
Anorectal disorders can really hurt your quality of life. They often need surgery to fix. These issues affect the anorectal area, causing pain and discomfort.
Hemorrhoids: Grades and Symptoms
Hemorrhoids are swollen veins in the lower rectum or anus. They can be internal or external. Symptoms include bleeding, itching, and pain.
Hemorrhoids are graded from 1 to 4 based on their severity:
- Grade 1: No prolapse
- Grade 2: Prolapse during defecation but reduce spontaneously
- Grade 3: Prolapse and require manual reduction
- Grade 4: Irreducible prolapse
Anal Fissures: Causes and Presentation
Anal fissures are small tears in the anus lining. They cause pain and bleeding. They often come from constipation, diarrhea, or straining.
Acute fissures might heal with treatment. But chronic ones might need fissure surgery for healing and pain relief.
Anal Fistulas: Types and Classification
An anal fistula is an abnormal connection between the anus and skin. It can come from an abscess. Fistulas are classified by their location relative to the sphincter muscles:
- Intersphincteric: Between the internal and external sphincters
- Transsphincteric: Crossing both sphincters
- Suprasphincteric: Above the puborectalis muscle
- Extrasphincteric: Outside the sphincter complex
Fistula surgery aims to close the fistula without harming the sphincter.
Anal Abscesses: Formation and Complications
An anal abscess is a pus collection around the anus. It’s often from an infection. Symptoms include pain, swelling, and fever.
If not treated, it can turn into a fistula. Treatment usually involves surgery. Sometimes, anal abscess surgery is needed for complications or if it comes back.
Types of Anorectal Surgery Procedures
Surgical options for anorectal issues vary widely. They are chosen based on the condition and the patient’s health. Each procedure is tailored to meet specific needs.
Hemorrhoidectomy: Surgical Removal of Hemorrhoids
Hemorrhoidectomy removes swollen veins in the lower rectum or anus. It’s for grade III or IV hemorrhoids that don’t respond to other treatments. The goal is to reduce pain and aid in healing.
There are open and closed methods. The open hemorrhoidectomy leaves wounds open to heal. The closed hemorrhoidectomy uses sutures. The choice depends on the case.
Fistulotomy and Fistulectomy Techniques
Fistulotomy and fistulectomy treat anal fistulas. A fistulotomy cuts along the fistula to heal. A fistulectomy removes the fistula tract.
The choice depends on the fistula’s complexity and the patient’s condition. Fistulotomy is often used for simpler cases, preserving more muscle.
Lateral Internal Sphincterotomy for Anal Fissures
Lateral internal sphincterotomy treats anal fissures. It makes a small cut in the muscle to reduce spasms and aid healing.
This procedure helps the fissure heal and lowers the chance of it coming back. But, it’s important to choose the right patients to avoid complications.
Rectal Prolapse Repair Methods
Rectal prolapse happens when the rectum loses its attachments, causing it to protrude. Surgery can fix this through different methods.
The choice of rectal prolapse repair method depends on the patient’s health and the prolapse’s extent. Younger patients or those with significant prolapse often get abdominal approaches. Older or frailer patients might get perineal approaches.
Minimally Invasive Anorectal Procedures
Minimally invasive procedures have changed how we treat anorectal issues. They offer effective solutions with fewer side effects. These methods aim to cause less damage, reduce pain, and speed up recovery.
Rubber Band Ligation for Hemorrhoids
Rubber band ligation is a common treatment for hemorrhoids. It involves placing a rubber band around the base of the hemorrhoid. This cuts off its blood supply, causing it to shrink and eventually fall off. It works well for Grade 1 and 2 hemorrhoids.
The benefits of rubber band ligation include:
- It’s minimally invasive, with no need for surgical cuts.
- The procedure is quick and can be done in a clinic.
- Patients often recover quickly, returning to normal activities in a day.
Sclerotherapy: Injection Treatment
Sclerotherapy involves injecting a solution into the hemorrhoid to shrink it. Though less common today, it’s an option for some patients.
The advantages of sclerotherapy include:
- It’s minimally invasive and relatively painless.
- No anesthesia is needed, making it good for patients with certain health issues.
- Recovery is quick, but effectiveness can vary.
Infrared Coagulation and Laser Therapy
Infrared coagulation and laser therapy are modern treatments for hemorrhoids and other issues. Infrared coagulation uses infrared light to coagulate the tissue. Laser therapy uses a laser to remove or shrink the hemorrhoid.
Treatment | Description | Benefits |
Infrared Coagulation | Applies infrared light to coagulate hemorrhoid tissue | Minimally invasive, quick recovery, effective for small hemorrhoids |
Laser Therapy | Uses laser to remove or shrink hemorrhoids | Precise, less bleeding, promotes faster healing |
Both infrared coagulation and laser therapy are minimally invasive. They reduce complications and allow for quicker recovery times than traditional surgery.
Minimally invasive anorectal procedures are a big step forward. They offer patients less painful and more effective treatments. Understanding these options helps patients make better choices for their care.
Advanced Techniques in Anorectal Surgery
Advanced anorectal surgery has changed how we treat complex issues in the anorectal area. These new methods lead to better results, shorter recovery times, and more comfort for patients.
Transanal Endoscopic Microsurgery (TEM)
Transanal Endoscopic Microsurgery (TEM) is a new way to remove tumors and lesions from the rectum. It uses a special endoscope for precise surgery.
Benefits of TEM:
- Less invasive than traditional surgery
- Reduced risk of complications
- Faster recovery times
- Minimal scarring
Stapled Hemorrhoidopexy (PPH Procedure)
Stapled Hemorrhoidopexy, or the PPH procedure, treats hemorrhoids. It uses a stapling device to fix the hemorrhoidal tissue.
Key advantages of Stapled Hemorrhoidopexy:
- Reduced post-operative pain
- Shorter operative time
- Quicker return to normal activities
Procedure | Recovery Time | Pain Level |
TEM | 1-2 weeks | Mild |
Stapled Hemorrhoidopexy | 1-3 weeks | Moderate |
LIFT Procedure | 2-4 weeks | Moderate to Severe |
LIFT Procedure for Complex Fistulas
The Ligation of Intersphincteric Fistula Tract (LIFT) procedure treats complex anal fistulas. It involves ligation of the fistula tract in the intersphincteric space.
Outcomes of LIFT Procedure:
- High success rate in closing fistulas
- Preservation of anal sphincter function
- Minimal post-operative pain
These advanced techniques in anorectal surgery are big steps forward. They give patients better and less invasive treatment options.
Preparing for Your Anorectal Surgery
Getting ready for anorectal surgery is key for a smooth process. It reduces risks and speeds up recovery. It’s all about being well-prepared.
Pre-Surgical Medical Evaluation
A detailed medical check-up is a must before surgery. It spots any health problems that might impact the surgery or recovery. Your doctor might run tests like blood work to check your health.
Tell your doctor about all medications you’re taking. This includes supplements and over-the-counter drugs. Some might need to be changed or stopped before surgery.
Dietary and Medication Guidelines
What you eat before surgery is important for recovery. Your doctor might suggest a special diet. This helps manage bowel movements and lowers the risk of complications.
- Avoid foods that can cause constipation or diarrhea.
- Stay hydrated by drinking plenty of water.
- Consider a liquid diet or low-fiber foods in the days leading up to your surgery.
Also, you might get medications to prepare your bowel for surgery. It’s important to follow these instructions. This helps prevent infection and ensures a good outcome.
Bowel Preparation Protocols
Cleaning your bowel is a big part of getting ready for surgery. It aims to reduce infection risks during and after surgery. Your doctor will give you specific instructions on how to do this, which might include:
- Using laxatives or enemas to clear the bowel.
- Following a clear liquid diet for a specified period.
- Avoiding certain foods and drinks that could interfere with the bowel preparation.
By following these guidelines, you can help make your surgery a success. And you’ll have a smoother recovery.
The Surgical Experience: What to Expect
When patients prepare for anorectal surgery, knowing what to expect can help them feel less anxious. The experience includes the type of anesthesia, whether it’s an outpatient or inpatient procedure, and the recovery process.
Anesthesia Options and Considerations
Anesthesia is key to ensuring comfort during surgery. The choice depends on the surgery type and the patient’s health.
- Local Anesthesia: Used for minor procedures, it numbs the area of surgery.
- Regional Anesthesia: Numbs a larger area, like below the waist, for more complex surgeries.
- General Anesthesia: Makes the patient unconscious for complex procedures.
A study in the Journal of Surgical Research found anesthesia choice affects recovery and satisfaction (Glass et al., 2018).
“The selection of anesthesia technique should be tailored to the individual patient and the specific anorectal procedure to optimize outcomes and minimize complications.”
— Expert Opinion
Outpatient vs. Inpatient Procedures
Surgeries can be done on an outpatient or inpatient basis. This depends on the surgery’s complexity and the patient’s health.
Procedure Setting | Description | Typical Procedures |
Outpatient | Procedures without an overnight stay. | Hemorrhoidectomy, Sclerotherapy |
Inpatient | Requires at least one night for monitoring. | Complex Fistula Repair, Rectal Prolapse Surgery |
Typical Duration and Immediate Recovery
Surgery time varies, from 15 minutes for simple procedures to hours for complex ones.
Recovery involves watching the patient, managing pain, and checking for complications. Patients are told how to care for themselves, including wound care and diet.
Knowing about the surgical experience can reduce anxiety and improve outcomes. Being informed helps patients prepare for the procedure and recovery.
Post-Surgical Recovery Process
Anorectal surgery is just the first step; a well-planned recovery is essential for minimizing complications and promoting healing. Effective post-operative care is key for a smooth recovery.
Immediate Post-Operative Care
Immediate post-operative care involves watching for any signs of complications and managing pain well. Patients are usually told to rest and avoid hard activities. Close observation for bleeding, infection, or other issues is vital.
Post-operative instructions from the healthcare team should be followed carefully to ensure proper healing.
Pain Management Strategies
Pain management after anorectal surgery is critical for patient comfort and to help with recovery. Various strategies can be used, including medication, dietary changes, and lifestyle adjustments. Pain relief medications are often given to manage post-operative pain.
It’s important to stick to the pain management plan given. If severe or unmanaged pain happens, tell the healthcare provider.
Activity Restrictions and Gradual Return to Normal
Activity restrictions after anorectal surgery are to prevent complications and help healing. Patients are told to avoid heavy lifting, bending, and hard activities for a while. A gradual return to normal activities is recommended, allowing the body to heal right.
Following these guidelines can greatly impact the recovery process. It can minimize the risk of complications and ensure a successful outcome.
Home Care After Anorectal Surgery
Proper care at home after anorectal surgery is key to avoiding complications and helping you heal. It includes wound care, dietary changes, and knowing when to get medical help.
Wound Care and Hygiene
Keeping the surgical site clean and promoting healing is vital. Keep the area clean by washing with warm water and mild soap. Pat dry; avoid rubbing or harsh products that could irritate the skin or disrupt healing.
Specific wound care instructions depend on your surgery. Your healthcare provider will give you detailed guidance tailored to your needs.
Dietary Recommendations for Healing
Eating a balanced diet rich in nutrients supports healing. Stay hydrated by drinking plenty of fluids. Eat foods high in fiber to help manage bowel movements and prevent constipation.
- Incorporate fruits, vegetables, and whole grains into your diet.
- Avoid foods that can cause discomfort or constipation.
- Consider a stool softener if recommended by your doctor.
Dietary Component | Recommended Foods | Foods to Avoid |
Fiber | Fruits, vegetables, whole grains | Processed foods, dairy (if constipating) |
Fluids | Water, clear broths | Caffeine, alcohol |
When to Contact Your Doctor
Knowing when to seek medical help is important. Contact your healthcare provider if you have:
- Severe pain not managed with prescribed medication.
- Excessive bleeding or discharge.
- Fever or chills.
- Difficulty urinating or severe constipation.
By following these guidelines and staying informed, you can navigate the post-operative period with confidence. This minimizes the risk of complications and supports a successful recovery.
Potential Complications and Risks
It’s important for patients to know the risks of anorectal surgery. This helps them make the best choice for their treatment. Anorectal surgery, like any surgery, has risks that need to be thought about carefully.
Bleeding and Hematoma Formation
Bleeding is a possible problem after anorectal surgery. It can be just a little spotting or a lot of bleeding that needs quick medical help. Another risk is hematoma, or blood outside blood vessels, which can cause more problems if not handled right.
Risk Factors for Bleeding:
- Use of anticoagulant medications
- Presence of bleeding disorders
- Surgical technique and complexity
Infection and Abscess Development
Infection is a common risk after anorectal surgery. It can show up as a wound infection or as an abscess, which is a pocket of pus that might need to be drained. Keeping the wound clean and following good hygiene is key to avoiding this risk.
Infection Risk Factors | Preventive Measures |
Poor wound care | Regular dressing changes |
Contamination | Use of sterile equipment |
Compromised immune system | Pre-surgical health optimization |
Urinary Retention and Urinary Tract Issues
Urinary retention, or not being able to empty the bladder, is a possible problem after anorectal surgery. It can happen because of pain, swelling, or nerve issues. Urinary tract infections (UTIs) are also a risk, mainly if a catheter is used.
Fecal Incontinence and Sphincter Damage
Fecal incontinence, or losing control over bowel movements, can happen if the anal sphincter muscles get damaged during surgery. This can really affect a patient’s quality of life and might need extra treatment or rehab.
Management Strategies:
- Pelvic floor physical therapy
- Biofeedback training
- Dietary adjustments
Long-term Outcomes and Success Rates
Looking at the long-term results of anorectal surgery helps patients know what to expect. The success of these surgeries depends on many things. This includes the type of problem being treated and the surgery method used.
Hemorrhoid Surgery: Recurrence Rates and Results
Hemorrhoid surgery is a common fix for severe hemorrhoids. Studies show that the success rate for this surgery is usually high. But, how often it works again can change based on the surgery method.
A study in the Journal of Surgical Research found a 10% chance of hemorrhoids coming back after a certain surgery within five years.
Stapled hemorrhoidopexy seems to work better for some, with lower rates of coming back. But, the right surgery depends on how bad the hemorrhoids are and the patient’s needs.
Surgical Technique | Recurrence Rate | Complication Rate |
Open Hemorrhoidectomy | 10% | 15% |
Stapled Hemorrhoidopexy | 5% | 10% |
Fistula Surgery: Healing and Recurrence
Fistula surgery tries to close an abnormal connection between the anus and skin. How well it works can change a lot. A study in Colorectal Disease found a 20% chance of the fistula coming back after a certain surgery.
The LIFT procedure might help lower the chance of fistulas coming back. It works by tying off the fistula tract without harming the muscles around it.
Fissure Treatment: Long-term Relief
Lateral internal sphincterotomy is a surgery for anal fissures that don’t get better with other treatments. Most people find a lot of relief from their symptoms after this surgery.
A review in the Journal of Gastrointestinal Surgery showed that over 90% of people healed after this surgery. But, there are worries about possible problems with bowel control.
In summary, the long-term results of anorectal surgery depend on many things. Knowing these outcomes helps patients make better choices about their health.
Innovations in Anorectal Surgery
Anorectal surgery is seeing big changes with new technologies and treatments. These changes are making care better, healing faster, and improving life for patients.
Laser and Radiofrequency Treatments
Laser and radiofrequency treatments are gaining popularity in anorectal surgery. They are less invasive and work well. Laser therapy is great for treating hemorrhoids and anal fissures. It helps wounds heal quicker and lowers the chance of problems.
- Minimally invasive procedures
- Reduced risk of complications
- Faster recovery times
Robotic-Assisted Colorectal Procedures
Robotic-assisted surgery is a big step forward in colorectal surgery. It gives surgeons more control and precision. Robotic systems help with complex surgeries, possibly leading to better results for patients.
- Enhanced precision and dexterity
- Better visualization of the surgical site
- Potential for reduced postoperative pain
Regenerative Medicine and Biological Therapies
Regenerative medicine and biological therapies are new and exciting in anorectal surgery. They aim to heal and repair tissues using biological materials and stem cells. Platelet-rich plasma (PRP) therapy is a treatment that could help wounds heal faster.
Therapy | Description | Benefits |
PRP Therapy | Uses platelet-rich plasma to stimulate healing | Enhanced wound healing, reduced recovery time |
Stem Cell Therapy | Utilizes stem cells to repair damaged tissue | Potential for tissue regeneration, improved outcomes |
These new developments in anorectal surgery are changing the game. They offer patients better and less invasive treatments. As technology keeps improving, we’ll see even more progress in treating anorectal conditions.
Selecting a Qualified Colorectal Surgeon
Finding a skilled colorectal surgeon is key for a smooth anorectal surgery and recovery. Your surgeon’s knowledge greatly affects your surgery’s success. So, picking the right one is very important.
Board Certification and Specialization
When looking for a colorectal surgeon, board certification is a must. It shows the surgeon has the right training and skills. Look for surgeons certified by the American Board of Colon and Rectal Surgery (ABCRS) or the American Board of Surgery (ABS).
Also, check if the surgeon specializes in colorectal surgery. A surgeon focused on this area is more likely to handle complex cases well.
Essential Questions for Your Surgical Consultation
At your first meeting, ask important questions to make a good choice. Here are some key questions to consider:
- What experience do you have with anorectal procedures?
- What are the possible risks and complications of my surgery?
- What results can I expect, and how will success be measured?
- How do you manage pain, and what options are there?
- How will my recovery be checked, and what aftercare can I expect?
Question | Purpose |
What experience do you have with anorectal procedures? | To assess the surgeon’s level of expertise |
What are the possible risks and complications? | To understand possible challenges and how they’re handled |
What are the expected outcomes? | To gauge the chance of a successful procedure |
The Value of Experience in Anorectal Procedures
Experience is very important in anorectal surgery. A surgeon with lots of experience can better handle any surprises during surgery. Studies show that surgeons who do more procedures have better results (Source: Helewa et al., 2017).
When looking at a surgeon’s experience, think about how many procedures they’ve done, their complication rates, and patient satisfaction. This info helps understand their skill level.
Financial Aspects of Anorectal Surgery
It’s important for patients to understand the financial side of anorectal surgery. The costs can change a lot based on the surgery type, insurance, and where you live.
Remember, these costs are just estimates. They can change based on the surgeon’s fees, hospital costs, and after-care.
Insurance Coverage and Pre-authorization
Most anorectal surgeries are covered by insurance, but how much can vary. It’s key to check your insurance and understand the pre-authorization process to avoid surprises.
Insurance usually covers part of the surgery fees, hospital stay, and follow-up care. But, you might have to pay for deductibles, copays, and coinsurance.
Payment Plans and Financial Assistance
If you don’t have enough insurance or are struggling financially, many providers offer payment plans or financial help. These options can make the surgery cost more affordable.
Talking to your healthcare provider or a financial counselor can help find the best financial solution for you.
Non-Surgical Management of Anorectal Conditions
Surgery isn’t the only fix for anorectal issues. Many treatments can help without surgery. These options can make life better for those affected.
Conservative Treatment Approaches
First, doctors often suggest non-surgical treatments. These include:
- Topical Treatments: Creams, ointments, or suppositories to ease pain and swelling.
- Sitz Baths: Warm water baths to help heal and ease pain.
- Medications: To soften stools, reduce pain, and manage symptoms.
Lifestyle and Dietary Modifications
Changing your lifestyle and diet can help a lot. Here are some tips:
- Increasing Fiber Intake: A fiber-rich diet can make stools softer and easier to pass.
- Adequate Hydration: Drinking enough water keeps stools soft.
- Regular Exercise: Exercise improves bowel function and overall health.
- Good Bowel Habits: Avoid straining and don’t delay bowel movements.
When to Consider Surgical Intervention
Even with non-surgical treatments, sometimes surgery is needed. This is true for:
- Severe Symptoms: When symptoms are very bad and affect daily life.
- Failed Conservative Management: If non-surgical treatments don’t work well enough.
- Complications: When problems like abscesses or fistulas need surgery.
Always talk to a doctor to figure out the best treatment plan. It depends on your condition and how severe it is.
Conclusion
Anorectal surgery treats many issues, like hemorrhoids and fistulas. It’s important for both patients and doctors to know the options and risks. This knowledge helps in making the right choices.
Understanding anorectal surgery is key to good care. There are many procedures, from simple to complex. These methods help patients find relief from their conditions.
When it comes to anorectal surgery, looking at long-term results is vital. This helps patients make better decisions. It also ensures they get the best possible outcome.
Anorectal surgery is complex. It shows the need for specialized care. This care is essential for effective treatment.
FAQ
What is anorectal surgery?
Anorectal surgery is a type of surgery for the anus and rectum. It treats problems like hemorrhoids, fissures, fistulas, and prolapse.
What are the common conditions that require anorectal surgery?
Common issues needing surgery include hemorrhoids, fissures, fistulas, abscesses, and prolapse.
What are the different types of anorectal surgery procedures?
There are many types of surgery, like hemorrhoidectomy, fistulotomy, and rectal prolapse repair. Each one treats a different problem.
What is the purpose of minimally invasive anorectal procedures?
These procedures, like rubber band ligation, aim to treat issues like hemorrhoids. They cause less damage and help you recover faster.
How do I prepare for anorectal surgery?
To prepare, you’ll have a medical check-up and follow dietary and medication advice. You’ll also do bowel prep as told by your surgeon.
What can I expect during the surgical experience?
You’ll get anesthesia during surgery. It might be done as an outpatient or inpatient, based on the surgery and your health.
How do I manage my recovery after anorectal surgery?
Recovery includes immediate care, managing pain, and following activity limits. Your doctor will guide you back to normal activities.
What are the possible complications and risks of anorectal surgery?
Risks include bleeding, infection, and issues with urination or bowel movements. But, these can be reduced with proper care and follow-up.
What are the long-term outcomes of anorectal surgery?
Outcomes vary by condition. Success rates differ for surgeries like hemorrhoid, fistula, and fissure treatments.
How do I choose a qualified colorectal surgeon?
Look for a board-certified surgeon with colorectal experience. Ask questions during your consultation to ensure they’re right for you.
What are the financial aspects of anorectal surgery I should be aware of?
Understand the costs, insurance, and payment options. Knowing this helps with planning and financial preparation.
Are there non-surgical management options for anorectal conditions?
Yes, there are non-surgical options. These include lifestyle changes, dietary modifications, and knowing when surgery is needed.
What are some innovations in anorectal surgery?
New treatments include laser, radiofrequency, and robotic-assisted procedures. These advancements offer more options for treatment.
What is the role of a proctology specialist in treating anorectal conditions?
A proctology specialist, or colorectal surgeon, is key in diagnosing and treating anorectal issues. They offer both surgical and non-surgical options.
Can anorectal surgery treat pelvic floor disorders?
Yes, some surgeries can treat pelvic floor disorders. They help repair or restore the pelvic floor’s function and anatomy.
References
National Center for Biotechnology Information. Evidence-Based Medical Insight. Retrieved from https://pubmed.ncbi.nlm.nih.gov/22696352/