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Learn where blood cells are made and why understanding hematopoiesis is key in diagnosing and treating blood disorders.

WHAT IS HAEMATOPOIESIS?

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WHERE DOES IT HAPPEN?

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DEVELOPMENTAL SHIFT OF LOCATIONS

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THE ROLE OF BONE MARROW

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HAEMATOPOIETIC STEM CELLS (HSCs)

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BLOOD CELL LINEAGE ORGANIZATION

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EXTRAMEDULLARY HAEMATOPOIESIS

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Stories

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WHERE DOES HAEMATOPOIESIS OCCUR?

WHAT IS HAEMATOPOIESIS?

Haematopoiesis is the process where hematopoietic stem cells transform into red cells, white cells, and platelets to support immunity, oxygen transport, and clotting.

WHERE DOES IT HAPPEN?

In adults, haematopoiesis primarily occurs in the bone marrow of the pelvis, vertebrae, sternum, and skull, where stem cells actively generate new blood cells.

DEVELOPMENTAL SHIFT OF LOCATIONS

Blood cell formation changes with age: yolk sac in embryos, liver and spleen in fetuses, long bones in children, and bone marrow in adults.

THE ROLE OF BONE MARROW

Bone marrow contains stem cells, stromal support cells, and a vascular network that regulates growth, differentiation, and release of mature blood cells.

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HAEMATOPOIETIC STEM CELLS (HSCs)

HSCs self-renew, enter dormancy when needed, and differentiate into all blood lineages, making them essential for lifelong blood production.

BLOOD CELL LINEAGE ORGANIZATION

Blood formation follows a hierarchy where stem cells become progenitors and then develop into myeloid or lymphoid lineages.

EXTRAMEDULLARY HAEMATOPOIESIS

When bone marrow function is impaired or demand increases, the liver, spleen, or lymph nodes may resume blood production, often seen in certain diseases.

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