Overview

Stomach Cancer Overview

Stomach cancer, also called gastric cancer, begins when abnormal cells in the stomach grow uncontrollably and form a tumor. The most common type is adenocarcinoma, which starts in the stomach lining. Other tumors can also develop in the stomach, including lymphomas, neuroendocrine tumors, and gastrointestinal stromal tumors. The disease is a type of gastrointestinal cancer, but it is different from cancers that begin in nearby organs.

Symptoms

Stomach Cancer Symptoms

Early stomach cancer symptoms may be mild, resemble common digestive problems, or be absent altogether. As the disease develops, changes may become more noticeable, but these signs also have many causes that are not cancer. Persistent or worsening stomach cancer symptoms should be assessed by a healthcare professional.

  • Indigestion
  • Feeling full quickly after eating
  • Upper-abdominal discomfort
  • Nausea
  • Vomiting
  • Trouble swallowing (dysphagia)
  • Unintentional weight loss
  • Loss of appetite
  • Fatigue caused by anemia
  • Black stools (melena)
  • A lump or swelling in the abdomen

WHEN SYMPTOMS NEED ATTENTION

Do not ignore persistent digestive changes

Most signs of stomach cancer have causes other than cancer, but persistent symptoms need medical assessment. Seek prompt advice for bleeding, black stools, vomiting, progressively worsening difficulty swallowing, or unexplained weight loss.

Causes

What Causes Stomach Cancer?

Stomach cancer begins when acquired or inherited changes disrupt the normal controls that regulate cell growth. Abnormal cells can then multiply, avoid normal cell death, and form a tumor in the stomach. The exact cause is often not known, and cancer usually develops through a combination of changes over time rather than from one immediate event.

Types of stomach cancer

Adenocarcinoma is the main type and starts in gland-forming cells of the stomach lining. Less common types include gastrointestinal stromal tumors, neuroendocrine tumors, and lymphomas, which arise from different cells or tissues and may require different treatments. Risk factors can make the cellular changes behind gastric cancer more likely, but they do not mean that a person will definitely develop it.

Risk Factors

Stomach Cancer Risk Factors

Risk factor categoryExamples and context
Non-modifiable factorsOlder age, a family history of gastric cancer, inherited syndromes, certain ancestry patterns, and previous stomach surgery.
Infections and stomach conditionsHelicobacter pylori infection, chronic gastritis, intestinal metaplasia, and other long-term changes in the stomach lining.
Potentially modifiable factorsTobacco use, excess alcohol use, and diets high in preserved or heavily salted foods.
Inherited riskSome inherited syndromes can substantially increase risk and may warrant genetic counseling or specialist follow-up.

Having one or more risk factors does not establish a diagnosis, and some people develop stomach cancer without an identifiable risk factor. A healthcare professional can interpret personal and family history in context.

Side Effects & Complications

Stomach Cancer Complications and Treatment Side Effects

DISEASE-RELATED PROBLEMS

Stomach cancer can cause bleeding, blockage, anemia, malnutrition, unintentional weight loss, eating difficulties, or spread to other organs. Tumor location and stage influence which complications occur.

TREATMENT-RELATED EFFECTS

Surgery, chemotherapy, radiation, targeted therapy, and immunotherapy may cause nausea, fatigue, infection risk, nerve symptoms such as neuropathy, bowel changes, and eating difficulties. Removing part or all of the stomach can also require long-term nutrition support.

The type and severity of complications depend on the tumor’s location, the stage of disease, the treatment used, and whether part or all of the stomach is removed. The care team can recommend medicines, dietary changes, monitoring, and supportive services to manage these problems.

CONTACT THE CARE TEAM PROMPTLY

Treatment symptoms that need urgent advice

Seek urgent medical advice for vomiting that prevents fluids, black or bloody stools, severe abdominal pain, fever during treatment, signs of dehydration, breathing problems, or rapidly worsening weakness.

Diagnosis & Staging

Diagnosis and Staging of Stomach Cancer

  • A medical history and physical examination help assess symptoms, general health, and possible risk factors.
  • Upper endoscopy allows a clinician to view the esophagus, stomach, and first part of the small intestine.
  • A biopsy removes small tissue samples during endoscopy so a pathologist can look for cancer cells.
  • Laboratory tests can assess blood counts, organ function, anemia, and overall readiness for treatment.
  • Imaging and staging procedures, such as CT, PET, MRI, endoscopic ultrasound, or laparoscopy, may be used when indicated.

What stomach cancer staging means

Staging considers how deeply the tumor has invaded the stomach wall, whether nearby lymph nodes contain cancer, and whether the disease has spread to distant organs. Earlier-stage disease is limited or more localized, locally advanced disease has grown further or reached nearby nodes, and metastatic disease has spread to distant sites. Stage helps guide treatment, but it does not by itself predict an individual outcome or determine exactly how a person will respond.

Treatment Options

Stomach Cancer Treatment Options

LOCAL TREATMENTS

Surgery may remove the tumor and part or all of the stomach when the cancer can be removed. Endoscopic treatment may be suitable for selected very early tumors. Radiation therapy can be used with other treatments or to relieve symptoms.

SYSTEMIC TREATMENTS

Chemotherapy treats cancer throughout the body. Targeted therapy and immunotherapy may be options when tumor testing shows relevant features. Clinical trials can provide access to treatments being studied.

Treatment depends on the stage, tumor type, biomarkers, overall health, and personal goals. Treatments may be combined before or after surgery, used to control unresectable or metastatic gastric cancer, or focused on symptom relief and quality of life when cure is not possible. A multidisciplinary oncology team can explain whether treatment is intended to cure, control, or ease symptoms.

Prevention

Stomach Cancer Prevention

  • Test for and treat Helicobacter pylori infection when a healthcare professional recommends it.
  • Avoid tobacco and ask for help with quitting if needed.
  • Limit alcohol use.
  • Maintain a balanced diet that includes a variety of nutritious foods.
  • Follow medical care and surveillance recommendations for precancerous stomach conditions.
  • Discuss inherited-risk counseling when a family history of stomach cancer is strong.

Outlook and Prognosis

Stomach Cancer Outlook and Prognosis

The outlook for stomach cancer depends mainly on the stage at diagnosis, whether the tumor can be completely removed, tumor biology, response to treatment, overall health, and access to specialist care. These factors also affect estimates sometimes described as the stomach cancer survival rate. A specialist can explain how population data relate to an individual’s specific situation.

Stage-dependent

Survival estimates vary according to how far the cancer has spread.

Group data

Published statistics describe groups of people, not one person's outcome.

Treatment-dependent

Response to treatment and tumor biology influence individual outlook.

Survivorship & Follow-up

Stomach Cancer Survivorship and Follow-Up

  • Attend scheduled oncology visits and complete symptom reviews and selected tests.
  • Follow the plan for monitoring possible recurrence.
  • Track nutrition, weight, hydration, and any need for dietary support.
  • Report and manage treatment-related effects, including fatigue, bowel changes, or nerve symptoms.
  • Seek emotional support from healthcare professionals, support groups, or trusted people.
  • Use rehabilitation services or specialist referrals when recommended.

Follow-up schedules are individualized according to stage, treatment, recurrence risk, and whether part or all of the stomach was removed. Contact the care team about new or persistent symptoms rather than waiting for the next appointment. Ongoing nutrition support can be especially important after stomach surgery.

Branches

3 topics

Tests & Procedure

1 topic

Symptoms

6 topics