Last Updated on November 25, 2025 by

Peyronie’s disease is a condition where scar tissue forms under the skin of the penis. This leads to curved and painful erections. It affects about 3-9% of men, mostly those over 50.

It’s important to understand Peyronie’s disease and its treatment. Even though it’s a chronic condition, about 75% of cases get better in 12-18 months. Tadalafil is one of the treatments available.

Key Takeaways

• Peyronie’s disease affects 3-9% of men, mainly those over 50.
• The condition can cause curved and painful erections.
• About 75% of cases stabilize within 12-18 months.
• Treatment options are available to manage the condition.
• Tadalafil is one of the treatment options for Peyronie’s disease.

5 Key Facts About Peyronie’s Disease Prevalence and Progression

Men over 50 are more likely to get Peyronie’s disease. This condition can make the penis curve and hurt. Knowing about it is key to understanding its effects and how it changes over time.

Defining Characteristics of Peyronie’s Disease

Peyronie’s disease makes scar tissue form inside the penis. This scar tissue, or plaque, can bend the penis and cause pain. It can also make the penis thinner. Knowing these details helps doctors diagnose and treat the disease.

Prevalence Rates: Affecting 3-9% of Men

Research shows Peyronie’s disease affects 3% to 9% of men. But it might be more common because some cases go unreported. It often strikes men in their 50s and 60s.

Age Distribution: Why It’s Common in Men Over 50

The exact cause of Peyronie’s disease is not known. But it’s believed to come from injuries to the penis. As men get older, these injuries become more likely. Men over 50 should watch for symptoms and see a doctor if they notice penile curvature or pain.

“Peyronie’s disease can really affect a man’s life. It impacts his health and his mind.”

The 12-18 Month Stabilization Timeline

Peyronie’s disease often takes 12 to 18 months to stabilize. During this time, it might get worse, stay the same, or even get a bit better. Knowing this helps men plan their treatment. Tadalafil, a common erectile dysfunction drug, is being studied for Peyronie’s disease. It might help improve blood flow and reduce curvature.

By learning about Peyronie’s disease, men can make better choices about their treatment. It’s important to talk to a doctor to find the best way to manage the condition.

The Permanence Question: 3 Possible Outcomes of Peyronie’s Disease

It’s important to know what Peyronie’s disease can lead to. This helps in setting realistic goals and choosing the right treatment. Peyronie’s disease can vary in how long it lasts, and understanding this helps both patients and doctors plan better.

Stabilization Without Complete Resolution (75% of Cases)

In about 75% of cases, Peyronie’s disease settles down within 12 to 18 months. But it often leaves a permanent bend and plaque. Starting treatment early might stop it from getting worse or even make symptoms better. While it’s good that the disease stabilizes, the bend and plaque can affect a man’s quality.

Relapsing or Remitting Course (12% of Cases)

For about 12% of men, Peyronie’s disease can get better and then worse again. This back-and-forth can be hard for patients. We aim to support and guide them through these ups and downs.

Factors That Determine Long-term Prognosis

Many things can affect how Peyronie’s disease will turn out in the long run. These include how severe the bend is, if there’s pain, and how well early treatment works. A good treatment plan can really change how the disease goes.We work with our patients to create plans that fit their specific needs.

By understanding these factors and possible outcomes, we can manage Peyronie’s disease better. This helps improve the lives of those affected.

Treatment Options Including Tadalafil for Peyronie’s Disease Management

Knowing the different treatments for Peyronie’s disease is key. The right treatment depends on how long you’ve had symptoms and how severe they are.

Non-Surgical Approaches: Oral Medications and Traction

Non-surgical treatments are often the first choice. Oral meds like tadalafil can help with symptoms. Tadalafil is known for treating erectile dysfunction and may also help with Peyronie’s by improving blood flow.

Traction therapy is another non-surgical method. It uses a device to stretch the penis. This can help reduce curvature over time. Research shows that traction therapy can improve penile curvature for some patients.

Tadalafil’s Mechanism and Efficacy in Peyronie’s Treatment

Tadalafil increases blood flow to the penis. It might help with Peyronie’s by improving erections and reducing curvature. Studies indicate tadalafil can be helpful, even when used with other treatments.

Injectable Treatments: CCH’s 34% Improvement Rate

Injectable treatments, like Collagenase Clostridium histolyticum (CCH), are promising. Clinical trials show CCH can reduce curvature by up to 34% in some patients. But these treatments can have side effects and may not work for everyone.

It’s important to talk to a healthcare professional to find the best treatment for you.

4 Ways Peyronie’s Disease Impacts Quality of Life

Peyronie’s disease can greatly affect a man’s life, touching both his physical and mental health. It impacts many areas of life.

Sexual Function Limitations

Peyronie’s disease can make sex painful and hard. Experts say there’s a strong link between Peyronie’s and erectile dysfunction. This is key to managing the condition.

“The pain and discomfort from Peyronie’s disease can make people avoid sex. This can hurt their relationship with their partner.”

Psychological Effects on Self-Image

The visible signs of Peyronie’s disease, like penile curvature, deeply affect a man’s self-image. Men often feel embarrassed, ashamed, and anxious.

These feelings can be as tough as the physical symptoms. They can hurt a man’s confidence and mental health.

Relationship Strain

Peyronie’s disease can put a strain on relationships. It brings sexual problems and emotional stress. This can make relationships more tense.

Studies show a 13% increased risk of separation in couples with Peyronie’s disease.

Benefits of a Multidisciplinary Care Approach

Managing Peyronie’s disease well needs a team effort. This includes doctors, psychologists, and counselors. Treating both the body and mind helps people deal with Peyronie’s better.

Dealing with Peyronie’s disease requires a detailed treatment plan. This is key to improving life quality.

Conclusion: Setting Realistic Expectations for Peyronie’s Disease Management

It’s important to understand what Peyronie’s disease can do and how it can be treated. We’ve talked about how common it is, its effects on daily life, and the treatments available, like Tadalafil.

Peyronie’s disease leads to scar tissue that can bend the penis, cause pain, and lead to hourglass syndrome. Though it’s tough to handle, there are ways to ease symptoms and improve life quality.

By knowing what to expect and looking into treatment options, people with Peyronie’s can make better choices. We suggest those affected to get medical help and talk to a doctor about their treatment options. This way, they can find the best plan for their situation.

FAQ

References

1. Sandean, D. P. (2024). Peyronie’s Disease. StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK560628/
2. Orsini, A., Bologna, E., Bignante, G., et al. (2025). Peyronie’s disease in the United States: A real-world, 13-year nationwide analysis of demographics, clinical characteristics, and treatment trends. Andrology. https://pubmed.ncbi.nlm.nih.gov/40195592/
3. Howell, S. (2025). Current insights and future directions in Peyronie’s disease. Neurourology and Urodynamics. https://onlinelibrary.wiley.com/doi/10.1002/uro2.104
4. Radiopaedia.org. (2024). Peyronie disease | Radiology Reference Article. https://radiopaedia.org/articles/peyronie-disease-1
5. British Association of Urological Surgeons. (2025). Peyronie’s disease. https://www.baus.org.uk/_userfiles/pages/files/Patients/Leaflets/Peyronies.pdf