Cancer Symptoms and Causes

Discover common cancer symptoms and potential causes evaluated through comprehensive oncology care.

Cancer Symptoms and Causes

Discover common cancer symptoms and potential causes evaluated through comprehensive oncology care.

Recognize early warning signs of childhood cancer and understand the genetic and environmental risk factors that may affect your child’s health.

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Cancer: Symptoms & Risk Factors in Children

Common Warning Signs of Cancer

Spotting cancer in children can be challenging because the early signs often look like symptoms of common illnesses, such as a cold or the flu. Since you know your child best, it is important to see a doctor if you notice any unusual symptoms that do not go away or get worse.

 Early warning signs can include:

  • A new lump or swelling anywhere on the body, especially the neck, belly, or armpit.
  • Unexplained paleness or constant extreme fatigue (tiredness).
  • Easy bruising or bleeding that seems abnormal, or a rash of small red spots (petechiae).
  • Frequent headaches, especially if they occur in the morning, are associated with vomiting.
  • Ongoing pain in one area, such as bone or back pain, that may wake a child at night.
  • A new limp or unexplained difficulty walking.
  • Sudden eye or vision changes or an unusual white glow in the center of the eye (retinoblastoma).
  • Unexplained weight loss in teenagers or slow growth in younger children.
  • Fevers or infections that do not go away or keep coming back.

Symptoms Needing Emergency Care

Cancer patients undergoing treatment require vigilant monitoring for certain symptoms that may indicate life-threatening complications. While many side effects are manageable, specific emergency signs demand immediate medical attention to prevent serious outcomes. Recognizing these critical symptoms early can be crucial for preventing treatment interruptions and ensuring patient safety. This guide highlights the key warning signs that warrant urgent emergency care during cancer treatment.

Seek urgent medical help if your child experiences any of the following:

  • Neurological Emergencies
    Sudden severe headache, seizures, vision changes, or confusion may indicate brain metastasis or spinal cord compression requiring immediate intervention.
  • Cardiopulmonary Crises
    Persistent chest pain, shortness of breath at rest, or coughing up blood could signal lung involvement or blood clots needing urgent evaluation.
  • Febrile Neutropenia
    A fever above 38.3°C with a low white blood cell count indicates a life-threatening infection risk requiring emergency antibiotics and hospitalization.
  • Severe Pain Uncontrolled by Medication
    Sudden, severe bone or abdominal pain unresponsive to prescribed medications may indicate fracture, obstruction, or organ involvement.
  • Bleeding and Thrombotic Events
    Uncontrolled bleeding, frequent nosebleeds, or sudden limb swelling with pain may indicate bleeding disorders or dangerous blood clots.
  • Metabolic Emergencies
    Extreme fatigue, confusion with nausea, or excessive thirst could signal dangerous electrolyte imbalances or tumor lysis syndrome.

These severe symptoms can sometimes be related to low blood counts or pressure on the central nervous system, requiring immediate attention.

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Risk Factors You Can Control

CANCER

Unlike adult cancers, most childhood cancers are not strongly linked to lifestyle choices. The cause is largely unknown in the majority of pediatric cancer cases. However, some environmental and lifestyle factors, primarily related to the mother’s exposure during pregnancy, are being studied.

  • Radiation Exposure: Minimize your child’s exposure to radiation from medical imaging tests like CT scans and X-rays unless necessary. For children who have had cancer, radiation therapy increases the risk of a future cancer.
  • Tobacco Smoke: Not smoking during pregnancy and avoiding secondhand smoke around your child may lower the risk of certain cancers, like leukemia.
  • Maternal Health: Controlling maternal obesity before and during pregnancy has been associated with a lower risk of childhood leukemia and brain tumors.
  • Chemical Exposure: Limiting a child’s or parent’s exposure to certain chemicals, like pesticides and solvents, may help reduce the risk of leukemia.
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Risk Factors You Cannot Control

CANCER

Most risk factors for childhood cancer are non-modifiable, meaning they are part of a child’s inherent makeup or are related to their early development.

  • Genetic Syndromes: Children born with certain inherited conditions, such as Down syndrome (which increases the risk of leukemia) or Li-Fraumeni syndrome, have a higher risk of developing cancer.
  • Family History: A strong family history of cancer, particularly specific rare syndromes like hereditary Retinoblastoma or Wilms tumor, increases a child’s risk. These cases often involve specific gene mutations.
  • Immune System Issues: Prior treatments for cancer using chemotherapy or radiation can increase the risk of a new cancer developing later. Also, having a weakened immune system due to conditions like AIDS increases risk.

Understanding Your Child's Total Risk

Cancer in children is rare, and most children with risk factors, even major ones, will never develop the disease. The majority of pediatric cancers are not caused by known environmental or lifestyle factors but by random DNA changes that happen early in life. If your child has a known genetic condition that increases risk, specialized screening and frequent checkups can help catch any potential cancer at the earliest, most treatable stage.

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Send us all your questions or requests, and our expert team will assist you.

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FREQUENTLY ASKED QUESTIONS

What are the warning signs of childhood cancer?

Warning signs include an unexplained lump or swelling, persistent and unexplained fevers, frequent headaches with vomiting, easy bruising, and extreme fatigue that doesn’t go away. Since these symptoms can be common childhood illnesses, it’s important to see a doctor for any persistent or concerning changes.

Children with specific inherited genetic syndromes, like Down syndrome or Li-Fraumeni syndrome, have a higher risk. Other high-risk factors include previous cancer treatment (chemotherapy or radiation) and exposure to high levels of ionizing radiation.

While most major cancer symptoms like fatigue, pain, and masses are similar, some specific types of tumors can appear more commonly in one gender (e.g., neuroblastoma is slightly more common in males). However, the most important symptoms to look for are general persistent changes in health.

Unlike adult cancers, lifestyle factors play a small role. Risk factors relate mostly to parental exposures, such as parental smoking (especially the father’s) and exposure to certain pesticides. Minimizing a child’s medical radiation and avoiding secondhand smoke are the main preventive steps.

In a small number of cases (5-10%), childhood cancers are linked to inherited gene mutations that run in families, such as the RB1 gene mutation for retinoblastoma. However, most childhood cancers are caused by genetic changes that happen randomly after the child is conceived and are not passed down.

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