How Long Can a Person Live with Congestive Heart Failure?
How Long Can a Person Live with Congestive Heart Failure? 3

Congestive heart failure is when the heart doesn’t pump blood well. It affects millions of people worldwide.

Knowing how long someone can live with heart failure is important. It helps patients and their families make better choices about treatment and quality of life.

Living with heart failure needs a full approach. This includes medical care, changing your lifestyle, and getting emotional support.

Key Takeaways

  • Congestive heart failure significantly impacts life expectancy.
  • Understanding the condition is key to managing it effectively.
  • Advancements in medical treatment improve the quality of life.
  • Lifestyle changes play a critical role in managing heart failure.
  • Emotional support is vital for patients and caregivers.

Understanding Congestive Heart Failure

To understand congestive heart failure, we need to know its definition, types, and causes. It’s a chronic condition where the heart can’t pump blood well. This leads to fatigue, swelling, and shortness of breath, affecting a person’s life quality.

Definition and Types of Heart Failure

Heart failure is different from cardiac arrest. It’s a gradual process where the heart can’t meet the body’s needs. There are two main types: systolic and diastolic.

Systolic heart failure happens when the left ventricle doesn’t contract well. Diastolic heart failure occurs when the left ventricle is stiff and can’t fill between beats.

Common Causes and Risk Factors

Several factors can cause congestive heart failure. These include coronary artery disease, high blood pressure, diabetes, and heart valve problems. Lifestyle factors like smoking, obesity, and a diet high in salt and fat also increase the risk.

Recognizing Early Warning Signs

Early detection of heart failure is key to better treatment. Common symptoms include shortness of breath, fatigue, swelling in the legs, ankles, and feet, and rapid or irregular heartbeat. Spotting these signs early can lead to timely medical evaluation and intervention, slowing the disease’s progression.

Stages of Heart Failure and Classification

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How Long Can a Person Live with Congestive Heart Failure? 4

It’s important to know how heart failure progresses. This condition means the heart can’t pump enough blood. It’s divided into different stages.

American Heart Association Stages (A-D)

 Stage A is for those at high risk but without heart disease. Stage B is for those with heart disease but no symptoms. Stage C is for those with heart disease and symptoms. Stage D is for those with severe heart failure needing special care.

New York Heart Association Functional Classification (I-IV)

The New York Heart Association (NYHA) Functional Classification also classifies heart failure. It ranges from Class I, where patients have no activity limits, to Class IV, where patients can’t do any activity without pain.

How Staging Affects Treatment Decisions

Heart failure staging affects treatment choices. For example, Stage A patients might just need lifestyle changes. But Stage C or D patients might need stronger treatments like medicines or devices. Knowing the stage helps doctors create better treatment plans for each patient.

By understanding heart failure stages, we can make better treatment choices. This improves patient care and helps manage heart failure better.

Heart Failure Life Expectancy: The Statistical Overview

Understanding heart failure survival rates is key. It depends on many factors. These include the stage of heart failure, treatment success, and the patient’s overall health.

General Survival Rates

Medical progress and lifestyle changes have boosted survival rates for heart failure patients. Survival rates vary widely. They range from nearly 90% for mild cases to much lower for advanced stages.

Five-Year Survival Statistics

Looking at five-year survival rates gives a clearer picture. The overall five-year survival rate is about 50%. But, this rate changes based on how severe the heart failure is.

Comparing Heart Failure Mortality to Other Conditions

It’s useful to compare heart failure mortality to other serious diseases. Here’s a table showing five-year survival rates for different conditions.

ConditionFive-Year Survival Rate
Heart Failure50%
Breast Cancer (all stages)90%
Colon Cancer (all stages)65%
Prostate Cancer (all stages)99%

The table shows heart failure’s impact on life expectancy. Yet, other serious conditions like some cancers also have high mortality rates. This comparison helps patients and doctors understand the prognosis better.

Early Stage Heart Failure Prognosis

The outlook for early-stage heart failure patients depends on many things. These include how well treatment works and the patient’s overall health.

Stage A and B Survival Rates

People with Stage A or B heart failure have a better chance of survival. This is compared to those diagnosed later.

  • Stage A patients are at high risk but don’t have structural heart disease yet.
  • Stage B patients have structural heart disease but haven’t shown symptoms of heart failure.

Survival rates for these stages are generally higher due to early intervention and management.

Factors Affecting Early Stage Outcomes

Several factors can impact the outcomes for early-stage heart failure patients. These include:

  • Underlying health conditions, such as diabetes or hypertension
  • Lifestyle factors, including diet, exercise, and smoking status
  • Adherence to prescribed treatment plans

Early identification and management of these factors can greatly improve patient outcomes.

Importance of Early Intervention

Early intervention is key to improving heart failure prognosis.

  • It starts treatments that can slow disease progression.
  • It offers a chance for lifestyle changes that boost heart health.

Advanced Heart Failure Life Expectancy

Advanced heart failure is a serious condition that can significantly affect life expectancy, influenced by factors such as the heart failure stage, other existing health issues, and the success of treatment.

The outlook for those with advanced heart failure varies. This depends on several important factors.

Survival Rates for Stage C and D Heart Failure

The American Heart Association divides heart failure into four stages (A-D). Stages C and D are the most severe, with significant symptoms and reduced function.

Survival for Stage C heart failure depends on treatment success and other health issues. For Stage D, or end-stage heart failure, life expectancy is shorter. At this point, the focus often turns to comfort care.

StageDescriptionTypical Survival Rate
CSymptomatic heart failure with structural heart diseaseVariable, often several years with proper management
DAdvanced symptoms, refractory to treatmentLimited, often less than a year without advanced therapies

End-Stage Heart Failure Considerations

End-stage heart failure, or Stage D, has severe symptoms hard to manage. At this stage, patients might need advanced treatments to improve their quality of life.

Options for end-stage heart failure include heart transplants, ventricular assist devices (VADs), and palliative care. These help manage symptoms and enhance life quality.

Hospice and End-of-Life Planning

For those with advanced heart failure not suited for more treatments, hospice care is key. Hospice focuses on comfort, symptom management, and support for patients and families at the end of life.

End-of-life planning is about discussing prognosis, treatment choices, and patient preferences with healthcare providers. It ensures care matches the patient’s wishes and values.

Key Factors Influencing Heart Failure Prognosis

Several key factors significantly impact the prognosis of patients with heart failure. Understanding these factors is essential for healthcare providers to develop effective treatment plans and for patients to manage their condition effectively.

Age and Gender Considerations

Age is a significant factor in heart failure prognosis. Older adults tend to have a poorer prognosis due to the presence of comorbidities and decreased physiological reserve. As stated by a study, “older patients with heart failure often present with more complex clinical profiles, making management more challenging.”

“The older the patient, the more likely they are to have multiple comorbid conditions that complicate heart failure management.”

Gender also plays a role, with some studies suggesting that men and women may have different outcomes due to underlying physiological differences.

We recognize that age and gender are not modifiable risk factors, but understanding their impact helps in tailoring treatment strategies. For instance, older patients may require more frequent monitoring and adjustments to their medication regimens.

Comorbidities and Their Impact

Comorbidities, or underlying health conditions, significantly affect heart failure prognosis. Conditions such as diabetes, hypertension, and chronic kidney disease can complicate heart failure management and worsen outcomes. The presence of multiple comorbidities can lead to a more complex clinical picture, making it challenging to manage heart failure effectively.

Common comorbidities include:

  • Diabetes mellitus
  • Hypertension
  • Chronic kidney disease
  • Chronic obstructive pulmonary disease (COPD)

Managing these comorbidities is critical to improving heart failure outcomes. This involves a treatment plan that addresses not just heart failure but also the associated conditions.

Ejection Fraction and Its Significance

Ejection fraction (EF) is a critical measure in heart failure, representing the percentage of blood that is pumped out of the left ventricle with each contraction. A reduced EF indicates systolic heart failure, while a preserved EF suggests diastolic heart failure. EF is a significant prognostic factor, with lower values generally associated with poorer outcomes.

The importance of EF lies in its ability to guide treatment decisions. For instance, patients with reduced EF may benefit from specific medications and device therapies aimed at improving cardiac function.

We understand that heart failure prognosis is multifactorial, involving age, gender, comorbidities, and ejection fraction among other factors. By considering these elements, healthcare providers can develop personalized treatment plans that improve patient outcomes.

Medication Management for Improved Outcomes

The right medication can greatly help those with heart failure. It’s key to manage medications well to improve life quality and outcomes.

ACE Inhibitors and ARBs

ACE inhibitors and ARBs are key in treating heart failure. They help blood vessels relax, making it easier for the heart to pump. This can improve heart function and reduce symptoms. Studies show ACE inhibitors can lower death and illness rates in heart failure patients.

ARBs are used for those who can’t take ACE inhibitors. Both types help slow heart failure disease progression.

Beta-Blockers and Their Benefits

Beta-blockers are vital in managing heart failure. They slow the heart rate and reduce blood pressure. Clinical trials show beta-blockers can improve survival and cut hospital stays in heart failure patients.

The best results come when beta-blockers are used with other heart failure drugs. This makes a complete treatment plan.

Diuretics and Other Essential Medications

Diuretics help manage fluid overload symptoms like edema and shortness of breath. They increase urine production. While they don’t improve survival, they’re key for better life quality in heart failure patients.

Other drugs, like mineralocorticoid receptor antagonists and hydralazine/isosorbide dinitrate, may be used too. They help tailor treatment to each patient’s needs.

In summary, managing medications is critical in treating heart failure. Knowing the different medications and their benefits helps doctors create personalized plans. This improves patient outcomes.

Surgical Interventions and Their Impact on Survival

Surgical interventions are key in managing heart failure. They help improve survival rates. For those with advanced heart failure, these surgeries can be lifesaving.

Coronary Bypass and Valve Procedures

Coronary artery bypass grafting (CABG) and valve repair or replacement are common surgeries for heart failure patients. CABG helps those with coronary artery disease by improving blood flow. Valve procedures are vital for patients with valvular heart disease, helping to restore normal function.

These surgeries can greatly improve survival and quality of life. For example, CABG can reduce mortality in severe coronary artery disease. Valve repair or replacement can also improve heart function and prognosis.

Heart Transplantation Outcomes

Heart transplantation is the top treatment for end-stage heart failure. It’s a complex procedure with risks, but many patients see positive outcomes. Post-transplant care has greatly improved, leading to better survival and quality of life.

Time Post-TransplantSurvival Rate
1 Year85-90%
5 Years70-75%
10 Years50-60%

Candidate Selection and Waiting List Considerations

Choosing candidates for heart transplantation involves a detailed evaluation. This includes medical history, current health, and recovery chances. Patients on the waiting list are closely watched, with priority based on condition severity and success likelihood.

Understanding heart failure surgeries is vital for healthcare providers and patients. Informed decisions about these procedures can greatly improve survival and quality of life.

Device Therapies Extending Life

Device therapies have changed how we treat heart failure. They help patients live better and longer. These devices support the heart, lessen symptoms, and boost survival chances.

Pacemakers and ICDs

Pacemakers and ICDs are key in fighting heart failure. Pacemakers keep the heart beating right by sending electrical signals. ICDs stop sudden death by shocking the heart when needed.

These devices are put under the skin and connect to the heart. The right choice depends on the patient’s health. ICDs have been shown to save lives in high-risk patients.

Cardiac Resynchronization Therapy (CRT)

CRT is a device therapy for some heart failure patients. It uses a pacemaker to sync the heart’s ventricles. This makes the heart work better and eases symptoms.

  • CRT helps those with left bundle branch block or unsynchronized ventricles.
  • It improves heart function, cuts down on mitral regurgitation, and boosts life quality.
  • Studies show CRT lowers hospital stays and death rates in the right patients.

Ventricular Assist Devices (VADs)

VADs are mechanical pumps that help the heart pump blood. They’re for those with severe heart failure who haven’t gotten better with other treatments.

VADs can be a temporary fix or a long-term solution for those not getting a transplant. They’ve been shown to save lives, reduce symptoms, and improve life quality.

In summary, device therapies are vital in heart failure care. Knowing about pacemakers, ICDs, CRT, and VADs helps doctors tailor treatments. This leads to better outcomes and a better life for patients.

Lifestyle Modifications for Better Prognosis

For those with congestive heart failure, making lifestyle changes can greatly improve their life. These changes help manage the condition better and lead to a better future.

Dietary Approaches for Heart Failure

Eating a heart-healthy diet is key for managing congestive heart failure. It’s important to eat less sodium, more fruits, vegetables, and whole grains. Also, drink less water as your doctor suggests.

The DASH diet is often suggested for heart failure patients. It focuses on:

  • Low sodium intake
  • High potassium-rich foods
  • More calcium and magnesium
NutrientRecommended Daily IntakeFood Sources
SodiumLess than 2,000 mgLimit processed and canned foods
Potassium3,500 mgBananas, leafy greens, potatoes
Magnesium400 mgNuts, seeds, dark leafy greens

Exercise Recommendations and Limitations

Doing regular exercise is good for heart failure patients. It boosts heart health and lessens symptoms. But, it’s important to stick to a plan made just for you.

Good exercises include:

  • Brisk walking
  • Swimming
  • Cycling

Don’t push too hard and watch for signs like shortness of breath or chest pain while exercising.

Stress Management Techniques

Keeping stress in check is important for heart health. Methods like meditation, deep breathing, and yoga can lower stress.

Stress management offers benefits like:

  • Lower blood pressure
  • Better sleep
  • Improved overall well-being

The Importance of Cardiac Rehabilitation

Cardiac rehabilitation is key in managing heart failure. It helps patients recover and manage their condition well. This approach includes exercise, education, and support.

Components of Effective Rehab Programs

Good cardiac rehab programs have several parts:

  • Exercise Training: Programs tailored to boost heart health.
  • Education: Tips on living heart-healthy, like diet and stress management.
  • Support: Counseling and groups to handle heart failure’s emotional side.

Measurable Benefits on Life Expectancy

Being in cardiac rehab can lead to improved survival rates and fewer hospital stays. Research shows that those in rehab tend to do better. They see:

  • Improved heart function
  • Better quality of life
  • Managed symptoms

Finding and Accessing Cardiac Rehab Services

To get the most from cardiac rehab, finding services is important. Here’s how:

  1. Talk to your doctor about rehab’s benefits.
  2. Look for programs at local hospitals or health centers.
  3. Make sure the program fits your health needs.

Adding cardiac rehab to treatment plans can greatly improve health and well-being for heart failure patients.

Monitoring and Managing Heart Failure Progression

It’s key to watch and manage heart failure to improve life quality. This means regular doctor visits, keeping an eye on your health, and knowing when to go to the emergency room.

Regular Medical Check-ups

Regular doctor visits are vital for heart failure care. They help doctors see how the condition is doing, change medicines, and talk about any issues. During these visits, doctors do several important things:

  • They look over your medical history and current symptoms.
  • They do a physical check, including weight and blood pressure.
  • They run lab tests, like blood work and electrocardiograms.
  • They might do imaging studies, like echocardiograms, if needed.

How Often to Visit: How often you see your doctor depends on your heart failure stage and health. Usually, people with stable heart failure see their doctor every 3-6 months. But, those with more serious or unstable heart failure might need to go more often.

Self-Monitoring Strategies

Watching your health yourself is a big part of managing heart failure. Knowing your condition and its signs helps you help yourself. Important self-monitoring steps include:

  1. Checking your weight every day to watch for fluid buildup.
  2. Tracking symptoms like shortness of breath, tiredness, and swelling.
  3. Keeping an eye on your blood pressure and heart rate as your doctor tells you.
  4. Following your medicine plan and telling your doctor about any side effects.

Keeping a Heart Failure Diary: Writing down your symptoms, weight, and any worries can be really helpful. It gives your doctor important information during check-ups.

When to Seek Emergency Care

Knowing when to go to the emergency room is very important for heart failure patients. Some symptoms mean you need help right away. These include:

SymptomDescription
Severe shortness of breathTrouble breathing even when sitting or lying down
Chest pain or discomfortPain or pressure in the chest, arms, back, neck, jaw, or stomach
Rapid or irregular heartbeatFeeling like your heart is racing or skipping beats
Severe fatigue or weaknessFeeling very tired or weak that stops you from doing daily things
Swelling or pain in the legs, ankles, or feetSudden or big swelling that might hurt

If you have any of these symptoms, go to the emergency room right away. Quick treatment can really help with heart failure.

Personalized Treatment Approaches

Personalized treatment is changing how we handle heart failure. It brings new hope for better patient results. By making treatment plans fit each patient, we can make life better and maybe even save more lives.

Genetic factors are key in personalized treatment. Genetic tests can show how a patient might react to certain treatments. This helps us choose the best treatments for each person.

Genetic Factors in Heart Failure Treatment

Genetics play a big role in heart failure. Some genetic changes can lead to heart problems. Knowing these can help us create better treatment plans for each patient.

Pharmacogenomics is also important. It studies how genes affect drug responses. By looking at a patient’s genes, we can pick the best heart failure medicines for them.

Age-Specific Considerations

Age is also important in treatment. Older patients often have more health issues and take more medicines. Younger patients might need to think about future family planning.

For older adults, managing health issues and drug side effects is key. We might adjust medicines to reduce risks. Younger patients might focus on lifestyle changes for long-term health.

Tailoring Therapy to Individual Needs

Creating a treatment plan that fits each patient is essential. We look at the heart failure cause, its severity, and any other health issues. This helps us make a plan that meets each patient’s needs.

Personalized treatment can greatly improve patient outcomes. For example, a patient with a certain genetic mutation might need a specific medicine. An older patient with many health issues might need a more detailed treatment plan.

In summary, personalized treatment is a big step forward in managing heart failure. By looking at genetics, age, and tailoring treatment, we can improve life quality and survival rates for heart failure patients.

P Palliative Care Approaches for Advanced Heart Failure

Palliative care is key for those with advanced heart failure. It focuses on easing symptoms and stress of serious illnesses. We’ll see how it fits into treatment plans for advanced heart failure.

Quality of Life Considerations

Palliative care boosts quality of life for heart failure patients. It covers physical, emotional, and social needs. Effective symptom management is a big part, ensuring patients get the right meds and therapy.

Patients often face symptoms like shortness of breath, fatigue, and pain. Palliative care teams create care plans that tackle these issues. This improves overall well-being.

Symptom Management Strategies

Symptom management is vital in palliative care for heart failure. It uses meds, lifestyle changes, and other methods to lessen symptoms. Effective communication is key for managing symptoms and making care decisions.

  • Optimizing medication regimens to control symptoms
  • Implementing non-pharmacological interventions such as oxygen therapy and physical therapy
  • Providing emotional and spiritual support

Discussing Prognosis and Care Goals

Talking about prognosis and care goals is important in palliative care. These talks ensure care matches the patient’s values and wishes. Advance care planning means understanding the patient’s wishes on life-sustaining treatments and other decisions.

Healthcare providers should have open and caring talks with patients and families. They should discuss prognosis, treatment options, and care goals. This approach focuses on the patient, ensuring they get the support they need as their condition worsens.

Psychological Aspects of Living with Heart Failure

Living with heart failure is more than a physical challenge. It deeply affects a person’s mental health and life quality. The diagnosis and how it progresses can change a patient’s mental state a lot.

Coping with Diagnosis and Prognosis

Getting a heart failure diagnosis can change a person’s life. They might feel shocked, deny it, or get anxious and depressed. Coping mechanisms are key to handling these feelings and adjusting to the new situation.

Good ways to cope include:

  • Getting support from loved ones
  • Going to counseling or therapy
  • Doing things that reduce stress, like meditation or yoga

Depression and Anxiety Management

Many heart failure patients deal with depression and anxiety. Managing these conditions is vital for a better life and well-being.

Ways to tackle depression and anxiety are:

  • Medicines from a doctor
  • Cognitive-behavioral therapy (CBT)
  • Joining support groups for heart failure patients

Support Systems and Resources

A strong support system is key for heart failure patients. This includes family, friends, doctors, and support groups.

There are many resources available:

ResourceDescriptionBenefits
Support GroupsGroups for heart failure patients to share experiencesEmotional support, practical advice
Counseling ServicesProfessional counseling for managing emotionsImproved mental health, coping strategies
Online ResourcesWebsites and forums providing information and supportAccess to information, community support

By focusing on the psychological side of heart failure, patients can live better and manage their condition better.

Recent Advances Improving Heart Failure Outcomes

New medical technologies and treatments are making a big difference for heart failure patients. These changes are not just making life better for patients. They also give hope for living longer.

Breakthrough Medications

Medicine for heart failure has seen big leaps forward. New drugs like angiotensin receptor-neprilysin inhibitors (ARNIs) and sodium-glucose cotransporter-2 (SGLT2) inhibitors are showing great promise. These medicines are not only easing symptoms and cutting down on hospital stays. They also might help people live longer.

ARNIs, for instance, have been found to cut down on heart-related deaths and hospital visits by 20% compared to older drugs. SGLT2 inhibitors, made for diabetes, are also showing heart benefits, like fewer hospital visits for heart failure.

Innovative Procedures and Technologies

New procedures and technologies are also key in fighting heart failure. Cardiac resynchronization therapy (CRT) and implantable cardioverter-defibrillators (ICDs) are getting better, giving patients more tailored care.

Ventricular assist devices (VADs), mechanical pumps for the heart, are also getting better. They’re lasting longer and working better, helping patients who are waiting for a heart transplant or as a long-term solution.

Promising Research Directions

There are exciting new research areas that could change how we manage heart failure. Gene therapy might help fix the heart’s problems at the source. Regenerative medicine could fix damaged heart tissue.

Also, using artificial intelligence (AI) and machine learning in heart care could make treatment more personal. It could also help predict how the disease will progress and improve treatment plans.

As we keep learning and improving heart failure treatment, the future looks bright. With these advances and ongoing research, we can make heart failure easier to manage. Patients will have a better quality of life and might even live longer.

Conclusion: Living Well with Heart Failure

Managing heart failure well is key to a better life and longer life. Knowing about the condition, its stages, and treatment options helps a lot. This knowledge lets people take action to live well with heart failure.

A good treatment plan is important. It should include medicines, lifestyle changes, and support. Regular doctor visits, tracking your health, and knowing when to call for emergency help are also important.

Thanks to new medical technologies and treatments, heart failure patients have a better future. Working with doctors and following a treatment plan tailored to you can greatly improve your health and well-being.

FAQ

What is congestive heart failure, and how does it affect life expectancy?

Congestive heart failure means the heart can’t pump enough blood. It can shorten life expectancy. But, with the right treatment, many people can live active lives for years.

How is heart failure classified, and what are the different stages?

Heart failure is divided into stages A-D by the American Heart Association. The New York Heart Association also has stages I-IV. These help doctors understand how severe it is and decide on treatment.

What are the general survival rates for heart failure patients?

Survival rates for heart failure patients vary. The five-year survival rate is about 50%. Early treatment can improve these numbers.

How does early-stage heart failure prognosis compare to advanced heart failure?

Early-stage heart failure has a better prognosis than advanced. Early treatment can slow disease progression and improve outcomes.

What factors influence heart failure prognosis, and how can they be managed?

Factors like age, gender, and health conditions affect heart failure prognosis. Managing these with medication and lifestyle changes can improve life expectancy.

What role do medications play in managing heart failure, and what types are commonly used?

Medications are key in managing heart failure. They reduce symptoms and slow disease progression. 

What surgical interventions are available for heart failure, and how do they impact survival?

Surgery, like coronary bypass and heart transplantation, can greatly improve survival. Choosing the right surgery and managing the waiting list are important.

How do device therapies, such as pacemakers and ICDs, extend life in heart failure patients?

Devices like pacemakers and ICDs help heart failure patients by regulating heart rhythm. They improve heart function and support pumping ability.

What lifestyle modifications can improve heart failure prognosis, and how can they be implemented?

Changes like diet, exercise, and stress management can help heart failure patients. These improve symptoms and overall well-being.

How does cardiac rehabilitation improve heart failure outcomes, and what are its benefits?

Cardiac rehabilitation enhances heart function and reduces symptoms. It includes exercise, education, and support, improving quality of life.

Why is monitoring and managing heart failure progression important, and how can it be done effectively?

Monitoring heart failure is key to prevent complications and improve survival. Regular check-ups, self-monitoring, and knowing when to seek emergency care are important.

What is palliative care, and how does it support advanced heart failure patients?

Palliative care improves quality of life for advanced heart failure patients. It manages symptoms, addresses emotional needs, and supports patients and families.

How can individuals cope with the psychological aspects of living with heart failure?

Managing stress, anxiety, and depression is important. Support systems, resources, and stress management techniques can help. It’s vital to address the emotional impact.

What recent advances are improving heart failure outcomes, and what promising research directions are being explored?

New treatments and procedures are improving heart failure outcomes. Research is exploring gene therapy and stem cell therapy to further enhance survival and quality of life.

References

National Center for Biotechnology Information. Evidence-Based Medical Insight. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772780/

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