Clinical Immunology focuses on the immune system’s health. Learn about the diagnosis and treatment of allergies, autoimmune diseases, and immunodeficiencies.
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Diagnosing sarcoidosis is a complex process because there is no single definitive test. It is considered a “diagnosis of exclusion,” meaning physicians must rule out other diseases that look similar, such as tuberculosis, lymphoma, or fungal infections. The diagnostic pathway at Liv Hospital involves establishing a compatible clinical picture, obtaining histological proof of non-caseating granulomas, and ensuring no other cause exists. This rigorous evaluation ensures that patients receive the appropriate management for their specific condition.
The chest X-ray is often the first test used and helps categorize the disease into the Scadding stages. These stages predict prognosis but do not strictly reflect disease severity in terms of symptoms.
The Four Stages
When an X-ray is inconclusive, a high-resolution chest CT provides detailed images of lung tissue.
Pattern Recognition
HRCT can reveal characteristic patterns such as perilymphatic nodules and ground-glass opacities that strongly suggest sarcoidosis.
PET Scans
Positron Emission Tomography (PET) scans are used to identify active inflammation throughout the body. They are handy for detecting cardiac sarcoidosis or for finding a suitable biopsy site.
In most cases, a tissue sample is required to confirm the diagnosis. The goal is to find the non-caseating granuloma.
Bronchoscopy
The most common method is a bronchoscopy with Endobronchial Ultrasound (EBUS). A flexible tube is passed into the lungs to sample lymph nodes or lung tissue without the need for surgical incisions.
Skin and Node Biopsy
If there are visible skin lesions or palpable neck lymph nodes, these are often easier and safer to biopsy than the lungs.
PFTs measure how well the lungs are working. They do not diagnose the disease, but are crucial for evaluating severity and monitoring progression.
Restriction and Obstruction
Sarcoidosis typically causes a restrictive pattern (reduced lung volume) and a decrease in diffusion capacity (the ability to transfer oxygen into the blood). However, it can sometimes cause airway obstruction.
Routine blood work helps assess overall health and look for markers of inflammation.
Angiotensin-Converting Enzyme (ACE)
ACE levels are elevated in about 60-80% of patients with active sarcoidosis. While not diagnostic on its own, it helps in monitoring disease activity.
Calcium Levels
Sarcoid granulomas produce Vitamin D, which can lead to high blood calcium levels (hypercalcemia) or increased urine calcium excretion (hypercalciuria). This can cause kidney stones or kidney failure if unchecked.
Because cardiac sarcoidosis can be silent but fatal, screening is essential.
ECG and Holter
A standard Electrocardiogram (ECG) is performed on all patients. If abnormalities are found or symptoms are present, a Holter monitor (24-hour recording) or cardiac MRI is ordered to evaluate heart muscle inflammation.
Every patient diagnosed with sarcoidosis requires a dedicated eye exam, even if they have no vision complaints.
Detecting Uveitis
Ophthalmologists use a slit lamp to examine the interior of the eye for inflammatory cells. Early detection of silent uveitis prevents long-term complications, such as adhesions between the iris and lens.
The most critical part of the diagnosis is proving it is not something else.
Tuberculosis and Fungal Infection
Special stains and cultures are performed on biopsy samples to rule out bacterial or fungal causes of the granulomas.
Lymphoma
Because swollen lymph nodes are a primary symptom, distinguishing sarcoidosis from lymphatic cancer is a priority during the pathology review.
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Not always. In classic cases of Lofgren’s syndrome (swollen nodes, arthritis, red leg bumps), doctors may diagnose sarcoidosis based on clinical signs alone without an invasive biopsy.
The ACE level reflects the total amount of granuloma burden in the body. However, it can be normal even in active disease, so it is just one piece of the puzzle.
No. In sarcoidosis, “Stage 4” refers to the X-ray appearance showing scarring (fibrosis), not terminal cancer staging. Many people with Stage 4 live active lives, though they may have breathing issues.
Bronchoscopy is done under sedation. Patients are generally asleep or very relaxed and do not feel pain during the procedure, though a sore throat is common afterward.
This test checks for excess calcium leaving the body. High calcium in urine can occur before blood calcium rises and puts you at risk for kidney stones.
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