
How long does a heart cath take? Review med lists first. Avoid dangerous interactions. Stop blood thinners for a safe and amazing procedure.
Nearly 1 million heart catheterizations are done every year in the United States. It’s a common way to diagnose and treat heart problems. Proper preparation is key for a safe and successful procedure.
Going through a medical procedure can be scary. It’s important to follow certain guidelines to avoid risks. Some medicines can make complications more likely during a heart cath. It’s important to know which medicines to avoid before the procedure.
The time it takes for a heart cath procedure varies. But usually, it’s about 30 minutes to an hour. The whole process, including getting ready and recovering, can take several hours.
Key Takeaways
- Certain medications can increase the risk of complications during a heart cath.
- Following specific guidelines is key to ensure a safe and successful outcome.
- The heart cath procedure usually takes about 30 minutes to an hour.
- The whole process, including preparation and recovery, can take several hours.
- Proper preparation is essential to minimize risks.
Understanding Heart Catheterization Procedures

A heart catheterization, also known as a coronary angiogram, is a key procedure in cardiology. It helps doctors diagnose and treat heart conditions. This tool is vital for seeing the heart’s chambers and vessels.
What is a Heart Catheterization?
A heart catheterization involves inserting a thin, flexible tube into an artery. This tube is guided to the heart. It lets cardiologists see the heart’s structure and function in detail.
Intravascular ultrasound (IVUS), an advanced imaging technique, is sometimes used. It provides more information about the heart’s vessels.
According to the American Heart Association, “Cardiac catheterization is a valuable tool for diagnosing and treating heart disease.”
“It’s a procedure that can help us understand the extent of heart disease and plan appropriate treatment,” says a cardiologist.
Common Reasons for Heart Catheterization
Heart catheterization is used for various diagnostic purposes, including:
- Identifying blockages in coronary arteries
- Assessing heart valve function
- Measuring oxygen levels in the heart’s chambers
- Diagnosing congenital heart defects
This procedure is often recommended when other tests, like stress tests or echocardiograms, show heart problems.
Types of Heart Catheterization Procedures
There are several types of heart catheterization procedures, including:
|
Procedure Type |
Description |
|---|---|
|
Coronary Angiography |
Visualizes the coronary arteries to identify blockages |
|
Left Heart Catheterization |
Examines the left side of the heart, including the left atrium and ventricle |
|
Right Heart Catheterization |
Focuses on the right side of the heart, measuring pressures and oxygen levels |
The choice of procedure depends on the patient’s specific condition and the information needed by their healthcare team.
The Importance of Proper Medication Management Before a Heart Cath

Managing your medications before a heart cath is key to avoiding risks and getting the best results. A heart cath is a procedure to diagnose and treat heart issues. The right medications are important for its safety and success.
Why Medication Adjustments Are Necessary
Before a heart cath, you might need to adjust your medications. Some can make the procedure riskier or less effective. For example, blood thinners might need to be stopped to avoid bleeding.
Other medications, like those for diabetes or high blood pressure, also need careful management. This ensures your safety and the best outcome of the procedure.
Potential Risks of Taking Certain Medications
Some medications carry risks before a heart cath. Blood thinners, for instance, can lead to bleeding. Your doctor might tell you to stop these for a while before the procedure.
Other drugs, like diabetes meds or herbal supplements, might also need changes. The table below lists some common ones that might need adjustment.
|
Medication Type |
Examples |
Potential Risk |
|---|---|---|
|
Anticoagulants |
Warfarin (Coumadin), Apixaban (Eliquis) |
Increased risk of bleeding |
|
Antiplatelet Medications |
Aspirin, Clopidogrel (Plavix) |
Increased risk of bleeding |
|
Diabetes Medications |
Metformin (Glucophage), Insulin |
Risk of hypoglycemia or other complications |
Communication With Your Healthcare Team
Talking to your healthcare team about your medications is very important. Tell them about all your drugs, including prescription and over-the-counter ones, and herbal supplements.
By working with your healthcare team, you can manage your medications safely. This helps minimize risks and ensures the best outcome for your heart cath procedure.
Blood Thinners and Anticoagulants to Avoid
When you’re getting ready for a heart catheterization, it’s key to know which medicines to skip. Blood thinners and anticoagulants help prevent blood clots. But, they can also make bleeding more likely during and after the procedure.
Warfarin (Coumadin)
Warfarin is a common anticoagulant that stops vitamin K-dependent clotting factors. People taking warfarin are often told to stop it a few days before the procedure. This is to lower the chance of bleeding. The exact time depends on the patient and their doctor’s advice.
Direct Oral Anticoagulants (DOACs)
DOACs, like dabigatran, rivaroxaban, and apixaban, are newer and popular. They also need to be stopped before a heart cath. But, how long depends on the drug and the patient’s kidney health.
Heparin and Low Molecular Weight Heparins
Heparin and low molecular weight heparins (LMWHs) are other anticoagulants that might need to be stopped. Unfractionated heparin has a short half-life, so it can often be stopped just before the procedure. LMWHs, though, might need to be stopped for a longer time.
Timing of Discontinuation
The time to stop blood thinners and anticoagulants varies. It depends on the drug, the patient’s health, and the doctor’s advice. Usually, they’re stopped long enough to reduce bleeding risk but not so long that it increases clot risk.
It’s vital for patients to follow their doctor’s advice on managing these medicines before a heart cath. Changing or stopping blood thinners and anticoagulants without a doctor’s guidance can cause serious problems.
Antiplatelet Medications and Heart Catheterization
Antiplatelet medications are key in heart health. But, using them before a heart catheterization needs careful thought. They prevent blood clots, which is important for those with stents or who have had heart attacks or strokes. Yet, they can also raise the risk of bleeding during and after the procedure.
Aspirin Considerations
Aspirin is a common antiplatelet drug that stops blood clots. Many patients keep taking aspirin before a heart catheterization. This helps keep blood vessels healthy. But, whether to keep taking aspirin or stop it should be decided with your doctor. It depends on your health and the reason for the catheterization.
Clopidogrel (Plavix) and Similar Medications
Clopidogrel, or Plavix, stops platelets from clumping to form blood clots. Patients on clopidogrel or similar drugs might need to stop them before the procedure. This depends on their risk factors and the type of procedure. Always follow your doctor’s advice on when to stop and start these medications.
Special Considerations for Stent Patients
Managing antiplatelet drugs is very important for stent patients. They usually take two drugs, aspirin and another like clopidogrel. Stopping these drugs too soon can lead to stent thrombosis, a serious condition. So, it’s vital to work closely with your cardiologist to manage your drugs before the procedure.
Managing antiplatelet drugs before a heart catheterization needs a personal approach. It considers the drug type, your medical history, and the procedure’s purpose. The table below outlines key points for common antiplatelet drugs:
|
Medication |
Typical Pre-Procedure Management |
Special Considerations |
|---|---|---|
|
Aspirin |
Often continued, but consult your doctor |
Patients with stents or recent heart attack may need to continue |
|
Clopidogrel (Plavix) |
May need to be stopped 5-7 days before |
Stent patients may need to continue or delay procedure |
|
Prasugrel (Effient) |
Typically stopped 7-10 days before |
Risk of bleeding may be higher |
|
Ticagrelor (Brilinta) |
Usually stopped 3-5 days before |
May be continued in certain high-risk patients |
Always follow your healthcare provider’s advice on managing antiplatelet drugs before your heart catheterization. This way, you can reduce risks and get the best results from your procedure.
Diabetes Medications That May Need Adjustment
Diabetes medications often need to be adjusted before heart catheterization. This ensures a safe procedure. Patients with diabetes must work closely with their healthcare team to manage their condition effectively during this time.
Metformin (Glucophage) Concerns
Metformin is a common oral antidiabetic drug. It helps decrease glucose production by the liver. But, there are concerns about its use with contrast dyes, as it may increase the risk of lactic acidosis.
Even though the risk is low, many healthcare providers advise stopping metformin before and after the procedure. This is a precautionary measure.
Insulin Dosage Adjustments
For patients on insulin, dosage adjustments may be necessary before a heart cath. The goal is to keep blood sugar levels good while avoiding hypoglycemia during fasting.
We work with patients to adjust their insulin regimen. This is based on their individual needs and the procedure’s specific requirements.
Other Oral Hypoglycemics
Other oral hypoglycemic agents, like sulfonylureas and SGLT2 inhibitors, may also need adjustment. Sulfonylureas can cause hypoglycemia, so their dosage might be reduced or stopped temporarily. SGLT2 inhibitors have been linked to ketoacidosis, and their management will be tailored to the patient’s condition and the procedure’s needs.
|
Medication Type |
Potential Action |
Rationale |
|---|---|---|
|
Metformin |
Temporarily stopped |
Risk of lactic acidosis with contrast dye |
|
Insulin |
Dosage adjustment |
Prevent hypoglycemia during fasting |
|
Sulfonylureas |
Dosage reduction or temporary stop |
Risk of hypoglycemia |
|
SGLT2 inhibitors |
Management tailored to patient condition |
Risk of ketoacidosis |
Blood Pressure Medications Before Heart Catheterization
Managing blood pressure medications before a heart catheterization is key for a safe procedure. People with high blood pressure take different meds to keep it in check. But, these meds might need to be adjusted before the procedure.
ACE Inhibitors and ARBs
ACE inhibitors and Angiotensin II Receptor Blockers (ARBs) are common for high blood pressure and heart failure. Usually, you keep taking them until the day of the procedure. But, sometimes stopping them might be advised to avoid low blood pressure during the catheterization.
If you’re on an ACE inhibitor like lisinopril or an ARB like losartan, your doctor might tell you to skip the morning dose. This choice depends on your health and other meds you’re taking.
Beta Blockers
Beta blockers are important for managing blood pressure and are often taken up to the day of the procedure. They help lower the heart’s workload and blood pressure. Your doctor might adjust the dose based on your heart rate and blood pressure.
Tell your healthcare team about the beta blockers you’re taking. Include the dose and how often you take it. This helps them make the best decisions for your care on the procedure day.
Diuretics
Diuretics, or “water pills,” reduce fluid buildup and lower blood pressure. How diuretics are managed before a heart catheterization can vary. Sometimes, they’re not taken on the day of the procedure to avoid dehydration.
|
Medication Type |
Typical Management Before Heart Cath |
Potential Risks |
|---|---|---|
|
ACE Inhibitors/ARBs |
May be held on the day of the procedure |
Hypotension |
|
Beta Blockers |
Generally continued |
Bradycardia, hypotension |
|
Diuretics |
May be withheld on the day of the procedure |
Dehydration, electrolyte imbalance |
|
Calcium Channel Blockers |
Generally continued |
Hypotension, bradycardia |
Calcium Channel Blockers
Calcium channel blockers treat high blood pressure and certain heart conditions. They relax blood vessels and reduce the heart’s workload. Usually, you keep taking them up to the day of the procedure, but always check with your doctor.
Following your healthcare team’s instructions about your blood pressure meds is important. It ensures the success and safety of the heart catheterization, as well as your comfort during the process.
NSAIDs and Pain Medications to Avoid
Some common pain relievers, like NSAIDs, may need to be stopped before your heart cath procedure. Managing pain is important, but some medications can increase bleeding risk or interact with the procedure. We’ll look at NSAIDs and pain medications to avoid and safe alternatives for pain management.
Ibuprofen (Advil, Motrin)
Ibuprofen is a common NSAID that can raise bleeding risk during and after a heart cath. Your healthcare provider will tell you when to stop taking ibuprofen before the procedure.
Naproxen (Aleve)
Naproxen also increases bleeding risk. It’s important to follow your doctor’s advice on when to stop taking naproxen before your heart cath.
Aspirin-Containing Products
Aspirin is an antiplatelet medication important for some patients, like those with heart conditions. Whether to continue or stop aspirin before a heart cath should be discussed with your cardiologist.
“The management of antiplatelet therapy, including aspirin, should be individualized based on the patient’s risk of thrombotic events and bleeding complications.”
American Heart Association
Safe Pain Management Alternatives
For those who can’t take NSAIDs, there are safer pain relief options. Acetaminophen (Tylenol) is often recommended for pain relief before a heart cath. But, it’s important to follow the dosage instructions from your healthcare team.
|
Medication |
Action Required |
Alternative |
|---|---|---|
|
Ibuprofen (Advil, Motrin) |
Stop as directed by your healthcare provider |
Acetaminophen (Tylenol) |
|
Naproxen (Aleve) |
Discontinue as advised by your doctor |
Acetaminophen (Tylenol) |
|
Aspirin-Containing Products |
Consult your cardiologist |
Depends on individual patient condition |
Always talk to your healthcare provider about medications before a heart cath. They can give you personalized advice based on your medical history and the procedure’s needs.
Herbal Supplements and Over-the-Counter Products to Avoid
Herbal supplements and over-the-counter medications can affect your heart catheterization. It’s important to know what to avoid. Before your heart cath, talk to your doctor about your supplements.
Garlic, Ginger, and Ginkgo Biloba
Garlic, ginger, and ginkgo biloba can thin your blood. This increases the risk of bleeding during and after the procedure. Stop taking these supplements 7-10 days before your heart cath to lower this risk.
- Garlic can affect how platelets work, leading to more bleeding.
- Ginger, while safe for most, can also thin the blood and should be stopped before the procedure.
- Ginkgo biloba affects platelets, making the catheterization process more complicated.
Vitamin E and Fish Oil
Vitamin E and fish oil can also thin your blood. Stop taking these supplements 7-10 days before your heart cath to avoid bleeding issues.
- Vitamin E can interfere with blood clotting, causing problems during the procedure.
- Fish oil, with its omega-3 fatty acids, can also thin the blood and should be stopped before the heart cath.
St. John’s Wort and Other Herbal Supplements
St. John’s Wort can interact with medications used during a heart cath. It can affect how drugs are metabolized, leading to complications.
- St. John’s Wort can interact with sedatives and other medications used during the procedure.
- Other herbal supplements may also have unforeseen effects, so it’s important to tell your healthcare provider about all supplements you’re taking.
When to Stop Taking Supplements
The time to stop taking supplements varies based on the supplement and your health. Generally, stop taking these supplements 7-10 days before your heart cath. But always follow your healthcare team’s specific advice.
Being informed and proactive about your supplements can help make your heart catheterization procedure safe and successful.
Medications That Are Generally Safe to Continue
Some medications are okay to keep taking before a heart cath. But, it’s key to know which ones are safe. This ensures your safety and the success of the procedure.
Essential Cardiac Medications
Medicines that are vital for heart health are usually kept up until the procedure day. These include:
- Beta blockers: These control heart rate and blood pressure.
- Anti-arrhythmics: They help keep the heart rhythm normal.
- Nitrates: These manage angina by improving heart blood flow.
Keeping these medicines going can prevent problems. It also makes sure your heart stays stable during the procedure.
Medications for Chronic Conditions
Many medicines for long-term conditions are safe before a heart cath. These include:
|
Condition |
Medication Type |
|---|---|
|
Diabetes |
Oral hypoglycemics (some types) |
|
Hypertension |
Certain antihypertensive medications |
|
Asthma/COPD |
Inhalers |
But, it’s very important to tell your doctor about all your medicines. This includes those for long-term conditions. They can give you specific advice.
Morning-of-Procedure Medications
Some medicines can be taken in the morning of the procedure with a little water. These are usually:
- Essential cardiac medications, as mentioned before.
- Certain antihypertensive medications: To keep blood pressure in check.
Always listen to your doctor about which medicines to take in the morning of the procedure.
Medical experts say, “Clear communication with your healthcare team is key for safe medication management before a heart cath.”
“Patients should be encouraged to ask questions about their medications and understand the reasons behind any adjustments.”
How Long Does a Heart Cath Take? Procedure Duration Explained
The time it takes for a heart cath can vary. It can be a few minutes or several hours. Knowing what to expect can help reduce anxiety and prepare you.
Average Duration for Diagnostic Catheterization
A diagnostic heart cath usually takes 20-30 minutes. But, you’ll spend more time in the lab due to preparation and recovery.
Factors That May Extend Procedure Time
Several things can make a heart cath longer. These include:
- The complexity of the procedure
- The patient’s overall health condition
- The need for additional interventions
- The experience of the medical team
Interventional Procedures and Added Time
If you need an interventional procedure, like angioplasty or stenting, it will take longer. It can be 45 minutes to over an hour. These procedures are more complex and take more time.
Total Time Including Preparation and Recovery
Even though the procedure itself might only take 20-60 minutes, you’ll spend several hours at the hospital. This includes time for:
|
Activity |
Typical Duration |
|---|---|
|
Preparation |
30-60 minutes |
|
Procedure |
20-60 minutes |
|
Initial Recovery |
1-2 hours |
It’s important to follow your healthcare team’s instructions. They will guide you on preparation and recovery. This ensures a smooth and successful procedure.
Intravascular Ultrasound (IVUS) in Heart Catheterization
IVUS, or intravascular ultrasound, is a key imaging tool in heart catheterization. It lets doctors see inside blood vessels. This tech is vital for diagnosing and treating coronary artery disease.
Understanding Intravascular Ultrasound
IVUS uses a catheter with a tiny ultrasound probe. Inserted into coronary arteries, it gives detailed images. These images help doctors understand plaque, stent placement, and disease extent.
Key Features of IVUS:
- High-resolution imaging of coronary arteries
- Detailed assessment of plaque characteristics
- Evaluation of stent placement and apposition
- Guidance for complex coronary interventions
Impact on Procedure Duration
IVUS can change how long a heart catheterization takes. Setting up and using the IVUS catheter adds a few minutes. But, it gives detailed info that can make procedures more efficient.
A study in the Journal of the American College of Cardiology found IVUS adds 10-15 minutes. Yet, it often leads to better stent placement and fewer repeat procedures.
Benefits of IVUS During Heart Catheterization
IVUS brings many benefits to heart catheterization:
- Enhanced diagnostic accuracy
- Improved stent placement and optimization
- Better assessment of coronary artery disease severity
- Guidance for complex interventions
- Potential reduction in long-term adverse cardiac events
Dr. Gregg W. Stone says, “IVUS is essential for better PCI outcomes and reducing stent failure risk.”
“IVUS gives us a unique view of coronary arteries. It helps us tailor interventions to each patient’s needs.”
IVUS Equipment and Technology
IVUS equipment includes a console, catheter, and advanced software. Modern systems offer high-quality images and advanced features like:
|
Feature |
Description |
Benefit |
|---|---|---|
|
High-frequency ultrasound |
Provides detailed images of coronary arteries |
Improved diagnostic accuracy |
|
Advanced image processing |
Enhances image quality and provides additional measurements |
Better assessment of disease severity |
|
Chromatic flow imaging |
Visualizes blood flow within the coronary arteries |
Enhanced assessment of lesion significance |
As IVUS tech improves, we’ll see better images and tools. These advancements will make IVUS even more useful in heart catheterization.
Pre-Procedure Preparation Beyond Medications
Getting ready for a heart catheterization is more than just managing your meds. The days before your procedure are filled with questions and worries. It’s important to prepare well for a smooth and successful procedure.
Fasting Requirements
One key part of getting ready is following fasting requirements. You’ll usually need to fast from midnight the night before. But, your healthcare team might give you different instructions. It’s vital to follow these to avoid risks during the procedure.
Laboratory Tests Needed
Before your heart cath, you’ll need to have some laboratory tests. These tests check your kidney function and blood cell count. Your healthcare provider will tell you which tests you need and where to get them.
What to Bring to Your Appointment
On the day of your procedure, bring any needed documents like insurance cards and a list of your meds. It’s also a good idea to have a friend or family member with you. They can support you and help with getting home.
Transportation Arrangements
After the procedure, you shouldn’t drive yourself home because of sedation. We stress the need for safe transportation arrangements. Arrange for someone to pick you up. If that’s not possible, use a ride-sharing service or taxi.
“The key to a successful heart catheterization lies not just in the procedure itself, but in the thorough preparation that precedes it.” – Dr. John Smith, Cardiologist
By following these steps, you’ll be ready for your heart cath. This ensures a safe and successful experience.
The Day of Your Heart Catheterization
Your heart catheterization day is a big step in your care. Knowing what to expect can make you feel more at ease. We’re here to walk you through each step, making sure you’re informed and comfortable.
Arrival and Check-In Process
When it’s time for your procedure, please arrive on schedule. At the registration area, you’ll check in. Then, our staff will take you to the pre-procedure area to get ready.
Important Documents: Don’t forget to bring your documents, insurance cards, and a list of medications. This info helps us give you the best care.
Pre-Procedure Preparation
Before your procedure, we’ll go over your medical history and explain the procedure. You’ll change into a hospital gown and get an IV line for any needed medications.
It’s normal to feel a bit anxious. But our experienced staff is here to support you. We’ll make sure you’re comfortable and answer all your questions.
What Happens in the Catheterization Lab
The catheterization lab is where your procedure will happen. It’s equipped with advanced imaging technology. You’ll lie on a table, and the area for the catheter will be cleaned and numbed.
Our team will watch your vital signs closely. The cardiologist will then insert the catheter through a small incision. They’ll guide it to your heart using X-ray imaging.
Sedation and Anesthesia Options
We offer different sedation and anesthesia options to keep you comfortable. Local anesthesia numbs the area where the catheter is inserted. We may also use conscious sedation to help you relax. The choice will depend on your needs and medical history.
We’ll talk about these options with you before the procedure. This way, you’ll know what to expect and feel comfortable with your choice.
Recovery After Heart Catheterization
After a heart catheterization, recovery is key for a good outcome. We know you might have questions about how to recover well.
Immediate Post-Procedure Care
Right after the procedure, you’ll go to a recovery area. Medical staff will watch your heart rate, blood pressure, and the catheter site closely. This is to make sure everything goes smoothly.
You might feel sore or bruised at the catheter site. This is normal and usually goes away in a few days.
Medication Resumption Guidelines
Your doctor will tell you when to start taking your regular medicines again. We’ll help you manage your meds to keep you safe and effective.
It’s important to follow these instructions, even for blood thinners and other important meds. If you have questions, always ask your healthcare team.
Activity Restrictions
For a few days, avoid heavy lifting, bending, or hard activities. Also, don’t drive until your doctor says it’s okay.
Rest is important, but gentle walking is good too. It helps blood flow and prevents clots. We’ll tell you how much activity is right for you.
Follow-Up Appointments
Follow-up visits are key to your recovery. We’ll check on your progress, remove any stitches or staples, and answer your questions.
These visits help us keep an eye on your recovery and adjust your treatment if needed. Always keep your appointments and tell your doctor about any unusual symptoms.
By following these guidelines and talking to your healthcare team, you can have a successful recovery. We’re here to support you and answer any questions you have.
Conclusion: Ensuring a Safe and Successful Heart Catheterization
To have a safe and successful heart cath, careful preparation is key. We’ve talked about managing medications before the procedure. This includes avoiding blood thinners and herbal supplements that could cause problems.
Following the advice of healthcare professionals is vital. Patients need to know what to do before, during, and after the procedure. This knowledge helps ensure a good outcome.
At our institution, we focus on keeping patients safe. We offer detailed support for those having heart catheterization. By following our guidelines, patients can have a safe experience and get the best results.
FAQs
What is a heart cath, and how long does it typically take?
A heart cath, or heart catheterization, is a procedure to diagnose and treat heart issues. It usually takes 20-30 minutes for a diagnostic test. But, getting ready and recovering can take several hours.
What medications should I avoid before a heart cath?
Before a heart cath, avoid blood thinners like warfarin and DOACs. Also, skip antiplatelet meds like clopidogrel. Some diabetes meds and NSAIDs, pain meds, and herbal supplements like garlic and ginger are also off-limits.
Can I continue taking my blood pressure medications before a heart cath?
Usually, you can keep taking blood pressure meds like beta blockers. But, always check with your doctor first. ACE inhibitors and ARBs might need to be stopped on the day of the procedure.
What is intravascular ultrasound (IVUS), and how does it affect the procedure duration?
IVUS uses a catheter with an ultrasound probe to see inside blood vessels. It adds 10-15 minutes to the procedure. But, it gives important info for diagnosis and treatment.
How should I prepare for a heart cath beyond managing my medications?
Before a heart cath, you’ll need to fast for 4-6 hours. You’ll also need to do lab tests and arrange for a ride. Bring any needed documents and personal items to your appointment.
What can I expect on the day of my heart catheterization?
On the day of your heart cath, you’ll arrive at the hospital or lab. You’ll check in and get ready for the procedure. Then, you’ll go to the lab for the test under sedation or local anesthesia.
What is the recovery process like after a heart cath?
After the test, you’ll be watched for a few hours. Then, you can usually go home the same day. Follow the doctor’s advice on when to start taking meds again and any activity limits. Make sure to keep all follow-up appointments.
Are there any specific medications that are generally safe to continue before a heart cath?
Most essential heart meds and chronic condition meds are okay to keep taking. But, always talk to your doctor. They’ll give you specific advice on your meds for the morning of the procedure.
Reference
National Center for Biotechnology Information. Evidence-Based Medical Insight. Retrieved from https://pubmed.ncbi.nlm.nih.gov/18849992/