
Prostate cancer cases have gone up a lot in the last ten years. This rise includes more cases of advanced prostate cancer. Because of this, prostate surgery is now a key treatment for many.
Robotic prostatectomy is a favorite choice for many. It’s known for its accuracy and quick recovery. But, like any surgery, it can have side effects that patients should know about.
We will look into the possible side effects of prostate removal. We’ll also talk about what patients might face after robotic prostate surgery.
Key Takeaways
- Robotic prostatectomy is a minimally invasive surgical treatment for prostate cancer.
- Potential side effects of prostate removal include urinary and sexual dysfunction.
- Patients should be aware of the risks and benefits associated with robotic prostate surgery.
- Understanding the side effects can help patients make informed decisions about their treatment.
- Robotic prostatectomy offers precision and reduced recovery time compared to traditional surgery.
Understanding Simple Robotic Prostatectomy

Robotic-assisted technology has changed prostate cancer surgery for the better. It makes treatments safer and more effective. Simple robotic prostatectomy is a type of surgery where the prostate gland is removed using advanced robotic systems.
Definition and Purpose of the Procedure
Simple robotic prostatectomy is a surgery where the prostate gland is removed with robotic help. Its main goal is to treat prostate cancer by taking out the gland. This stops the cancer from spreading.
The procedure involves several key steps: 1. Making small incisions in the abdomen to insert robotic arms. 2. Using a high-definition camera to provide a clear view of the surgical area. 3. Removing the prostate gland with precision, minimizing damage to surrounding tissues.
How Robotic-Assisted Technology Works
Robotic-assisted technology helps surgeons by giving them a clear, 3D view of the area. It also lets them make very precise movements. This reduces tremors and improves dexterity.
The benefits of robotic-assisted technology include:
- Reduced blood loss and less need for transfusions
- Less post-operative pain
- Shorter hospital stays
- Faster recovery times
A study found that robotic-assisted laparoscopic radical prostatectomy is a good treatment for prostate cancer. It has less risk and better results.
Candidates for Robotic Prostatectomy
Not all patients with prostate cancer can have robotic prostatectomy. The choice depends on the cancer’s stage, the patient’s health, and their preferences.
Typical candidates include:
- Men with localized prostate cancer
- Patients who are healthy enough for surgery
- Those who want to recover quickly and avoid complications
It’s key for patients to talk to their doctor. They need to decide if robotic prostatectomy is the best choice for them.
Common Immediate Side Effects After Surgery

Knowing the immediate side effects of robotic prostatectomy helps patients prepare for recovery. This surgery is advanced and effective but comes with challenges right after.
Post-Operative Pain and Discomfort
Patients usually feel pain or discomfort after surgery. This is normal. Pain management is key, and our team helps control pain.
Pain relief medications are commonly prescribed, with specific types and dosages tailored to each patient’s needs. It’s important to follow the medication plan to manage pain well.
|
Common Pain Management Strategies |
Description |
Benefits |
|---|---|---|
|
Medication |
Use of prescribed pain relief medications |
Effective pain control, reduced discomfort |
|
Rest |
Adequate rest and relaxation |
Aids in healing, reduces fatigue |
Urinary Catheter Management
A urinary catheter is used during surgery to drain urine. Proper management is key for a smooth recovery.
Patients get instructions on catheter care. This includes cleaning, infection monitoring, and managing discomfort. Following these steps is important to avoid infections and other problems.
Incision Site Bleeding and Bruising
Bleeding and bruising at the incision sites are common. These symptoms are usually mild and short-lived but need watching.
It’s important to look out for excessive bleeding or unusual bruising. Report these to your doctor right away. Proper wound care and follow-up visits are essential for healing.
Understanding these side effects helps patients navigate their recovery after robotic prostatectomy. It’s important to stay informed and follow doctor’s advice to avoid complications and get the best results.
Urinary Side Effects of Prostatectomy
Patients who have prostatectomy often face urinary side effects. These can be short-term or long-lasting. It’s important to know what causes them, their symptoms, and how to treat them.
Temporary vs. Persistent Urinary Incontinence
Urinary incontinence is a common side effect after prostate surgery. It means urine leaks out without control. There are different types, like stress, urge, and mixed incontinence.
Temporary urinary incontinence usually gets better in a few months. But, some people deal with persistent urinary incontinence, which is harder to manage.
- Stress incontinence happens when movement or pressure makes urine leak.
- Urge incontinence is when you suddenly need to pee and can’t hold it.
- Mixed incontinence is a mix of stress and urge incontinence.
Urinary Retention and Difficulty Voiding
Some patients have trouble peeing after prostate surgery. This might be because of swelling or scar tissue blocking the urine flow.
Urinary retention can be treated with a catheter. This helps drain the bladder. Sometimes, more treatments are needed to fix the problem.
“The key to managing urinary side effects is early intervention and proper care. Patients should work closely with their healthcare provider to develop a personalized treatment plan.”
Bladder Neck Contracture and Strictures
Bladder neck contracture and strictures can happen after prostate surgery. A contracture is when the bladder neck scars and narrows, blocking urine flow. Strictures are abnormal narrowings of the urethra.
These issues can lead to trouble peeing, weak urine flow, and other symptoms. Treatment might include dilation or surgery to widen the area.
It’s key for patients to know about urinary side effects of prostatectomy. By talking to their doctor, they can find ways to manage these issues. This helps improve their quality of life.
Sexual Function Changes After Robotic Prostatectomy
Men who have robotic prostatectomy often face changes in their sexual function. These changes include erectile dysfunction and dry orgasm. Knowing why these changes happen and how long they last can help manage expectations.
Mechanisms of Erectile Dysfunction
Erectile dysfunction (ED) is a common side effect of robotic prostatectomy. The main reason is damage to the neurovascular bundles during surgery. These bundles are near the prostate and are key for erections.
The amount of nerve damage affects how severe ED is. Other factors like age, pre-existing erectile function, and health conditions also play a role. Surgeons try to avoid damaging these nerves, but ED is a possible outcome.
Dry Orgasm and Ejaculatory Changes
Dry orgasm, or retrograde ejaculation, is another change men might face after robotic prostatectomy. This happens because parts of the reproductive system are removed during surgery. As a result, semen goes into the bladder instead of being ejaculated.
This condition is usually not harmful but can affect a man’s emotional aspect of sex. It’s important to know that dry orgasm is common and not a cause for worry.
Timeline for Sexual Function Recovery
The time it takes for sexual function to recover after robotic prostatectomy varies. The extent of nerve preservation, overall health, and pre-surgery sexual function all play a role.
Men can expect a slow improvement in erectile function over several months to a few years. Recovery times differ, and patience is key. Discussing any concerns with a healthcare provider is important.
Exploring treatment options for erectile dysfunction with a healthcare team is recommended. This includes medications, vacuum devices, and other therapies suited to individual needs.
Bowel Function Side Effects
Knowing about bowel function side effects after robotic prostatectomy helps patients prepare for recovery. These changes can affect a patient’s quality of life. They are less common than other side effects but important.
Managing Constipation After Surgery
Constipation is a common issue after robotic prostatectomy. Patients should take steps to manage their bowel movements. This includes drinking enough water, eating foods high in fiber, and using stool softeners or laxatives as advised by their doctor.
Tips for Managing Constipation:
- Drink plenty of water
- Eat foods rich in fiber
- Use stool softeners or laxatives as prescribed
- Engage in gentle physical activity
Understanding Rectal Injury Risks
Rectal injury is a rare but possible complication of robotic prostatectomy. We use precise techniques and carefully choose patients to reduce this risk. If a rectal injury happens, quick recognition and treatment are key to avoiding more problems.
Long-term Changes in Bowel Function
Many patients return to normal bowel function after recovery. But, some may experience long-term changes. These can include changes in bowel habits or chronic issues like constipation or fecal urgency. We closely monitor and address any ongoing bowel function changes with patients.
|
Bowel Function Aspect |
Short-term Changes |
Long-term Changes |
|---|---|---|
|
Constipation |
Common due to anesthesia and reduced mobility |
Less common, but may persist in some patients |
|
Rectal Injury |
Rare, but can occur during surgery |
Generally not applicable if no injury occurred during surgery |
|
Bowel Habits |
May be altered due to pain medication and dietary changes |
Usually returns to normal, but some patients may experience persistent changes |
Understanding bowel function side effects of robotic prostatectomy helps patients prepare for recovery. They can work closely with their healthcare team to manage any issues that come up.
Psychological Impact of Prostate Removal
The removal of the prostate affects many areas, including body image, mental health, and relationships. Men may feel a range of emotions after surgery. These feelings can change their quality of life.
Body Image and Masculinity Concerns
Removing the prostate can make men worry about their body image and masculinity. They might feel like they’ve lost a part of themselves. It’s important to talk about these feelings and get help when needed.
Some men might feel less masculine because of changes in their urinary or sexual function. Talking to a counselor or joining a support group can help.
Managing Anxiety and Depression
Anxiety and depression are common after prostate surgery. It’s key to recognize these signs and get professional help to manage them well.
|
Symptoms of Anxiety and Depression |
Management Strategies |
|---|---|
|
Feelings of worry, nervousness, or sadness |
Cognitive-behavioral therapy (CBT), medication |
|
Loss of interest in activities, changes in appetite or sleep |
Mindfulness practices, support groups |
Relationship and Intimacy Challenges
Prostate removal can also affect relationships and intimacy. Men and their partners may need to adjust to new situations, like changes in sexual function. Open communication and seeking professional advice can help.
It’s vital for partners to be involved in the recovery. They can offer emotional support and understanding. This can make the bond between partners stronger and help them cope with surgery changes.
Understanding the psychological effects of prostate removal is key to caring for men after surgery. By addressing body image, managing anxiety and depression, and dealing with relationship issues, men can handle the psychological side of recovery better.
Rare but Serious Complications
Though rare, serious complications can happen after robotic prostatectomy. It’s key for patients to know about these risks. This knowledge helps in spotting and managing them early.
Deep Vein Thrombosis and Pulmonary Embolism
Deep vein thrombosis (DVT) is when a blood clot forms in deep veins, usually in the legs. This can turn into a life-threatening pulmonary embolism (PE) if the clot moves to the lungs. We prevent this by using compression stockings and sometimes anticoagulant meds.
Symptoms of DVT include swelling, pain, or color changes in the leg. PE can cause sudden breath trouble, chest pain, or coughing up blood. Spotting these symptoms early is vital.
|
Condition |
Symptoms |
Preventive Measures |
|---|---|---|
|
Deep Vein Thrombosis |
Swelling, pain, discoloration |
Compression stockings, anticoagulant medications |
|
Pulmonary Embolism |
Shortness of breath, chest pain, coughing up blood |
Early mobilization, anticoagulant medications |
Surgical Site Infections and Sepsis
Surgical site infections (SSIs) are a risk with any surgery, including robotic prostatectomy. These infections can be mild or severe. In rare cases, they can cause sepsis, a dangerous condition where the body attacks its own tissues.
We follow strict infection control protocols to lower this risk. Watching for signs of infection, like redness, swelling, pain, or fever, is key after surgery.
Anesthesia-Related Complications
Anesthesia-related complications, though rare, can be serious. These include respiratory or cardiac problems, allergic reactions, or nerve damage.
Our anesthesiologists are very experienced. They do a detailed preoperative check to reduce these risks. Patients are also closely watched during and after the surgery.
Recovery Timeline After Robotic Prostatectomy
Recovering from robotic prostatectomy takes time. It includes several stages, from the hospital stay to getting back to normal. Knowing this timeline helps patients prepare and manage their expectations.
First Week: Hospital Stay and Early Recovery
The first week usually starts with a hospital stay, lasting 1 to 2 days. Medical staff watch over the patient closely, managing pain and looking for any immediate issues. After leaving the hospital, patients learn how to care for their urinary catheter and manage pain. They also learn to recognize signs of possible complications.
Weeks 2-6: Activity Restrictions and Healing
In weeks 2-6, patients start to do more but should avoid heavy lifting and bending. Following these activity restrictions is key for healing and avoiding complications like bleeding or hernia. Most can go back to light activities and desk work in 2-3 weeks.
Months 2-12: Return to Normal Function
Over the next months, patients see more improvement. Urinary continence and sexual function may take time to get back to normal. Most men see significant improvement in 6 to 12 months. Regular check-ups with healthcare providers are important to track progress and address any issues.
Understanding the recovery timeline helps patients navigate the post-operative period. They know what to expect and when to seek medical help if needed.
Managing Urinary Side Effects
Urinary side effects after robotic prostatectomy are common. But, there are ways to manage them well. It’s key to improve life quality during recovery.
Pelvic Floor Therapy Techniques
Pelvic floor therapy, or Kegel exercises, is important. It strengthens muscles that help with bladder control. Regular exercises can help control the bladder and lower incontinence.
Benefits of Pelvic Floor Therapy:
- Improved bladder control
- Reduced urinary incontinence
- Enhanced overall pelvic floor strength
A study found pelvic floor muscle training is vital after prostatectomy. It greatly improves continence recovery.
“The early start of pelvic floor rehabilitation can greatly lessen urinary incontinence after prostatectomy.”
Source: A urology research publication
Medications, Pads, and Containment Devices
Medications and devices also help with urinary side effects. Anticholinergics can lessen bladder spasms. Pads and adult diapers help manage incontinence.
|
Management Strategy |
Description |
Benefits |
|---|---|---|
|
Anticholinergic Medications |
Reduce bladder spasms |
Decreased urgency and frequency |
|
Pads and Adult Diapers |
Containment devices for incontinence |
Practical solution for leakage |
Advanced Interventions for Persistent Incontinence
For those with ongoing incontinence, there are advanced treatments. Bulking agents, slings, and artificial urinary sphincters can help. These aim to better urethral closure and improve continence.
Medical technology keeps improving. This makes managing urinary side effects after robotic prostatectomy more effective. It helps patients have a better life during recovery.
Addressing Sexual Dysfunction After Surgery
After a robotic prostatectomy, many patients face sexual dysfunction. This can include erectile dysfunction, low libido, and changes in ejaculation. These issues can be distressing, but there are ways to manage and possibly solve them.
Oral Medications and Injectable Therapies
Oral medications are often the first choice for erectile dysfunction after surgery. Drugs like sildenafil (Viagra) and tadalafil (Cialis) help by increasing blood flow to the penis. It’s important to talk to your doctor about these options, as they might not be right for everyone, like those with heart conditions.
If oral meds don’t work or cause side effects, injectable therapies might be an option. These involve injecting a drug directly into the penis to get an erection. But, you need to learn how to use them correctly.
Vacuum Devices and Penile Implants
Vacuum erection devices (VEDs) are another non-invasive choice. They work by creating a vacuum around the penis to draw blood and then use a ring to keep the erection. While effective, they might take some practice to use right.
For more severe erectile dysfunction, penile implants could be an option. There are inflatable and semi-rigid types, which are surgically placed. Discussing the risks and benefits with a urologist is key to deciding if this is right for you.
Sexual Counseling and Alternative Intimacy
Dealing with sexual dysfunction after surgery isn’t just about medical treatments. It’s also about the emotional and relational aspects of intimacy. Sexual counseling can help individuals and couples adjust to changes in their sexual relationship. It can also help explore new ways of intimacy and overcome psychological barriers.
Exploring alternative forms of intimacy, like sensual massage, can also be helpful. These activities can keep a sexual relationship fulfilling during recovery. We encourage patients and their partners to be open to these options as part of their recovery plan.
In conclusion, sexual dysfunction after robotic prostatectomy is not insurmountable. There are many treatments and strategies available. By working with healthcare providers and being open to different approaches, many men can regain a fulfilling sexual life after surgery.
Advantages of Robotic vs. Traditional Prostatectomy
Studies show robotic prostatectomy has many benefits over traditional surgery. It improves patient care and recovery. The advantages of robotic prostatectomy touch many parts of the patient’s experience and recovery.
Reduced Blood Loss and Transfusion Rates
Robotic prostatectomy reduces blood loss during surgery. Robotic-assisted technology makes dissection precise and minimizes invasion. This leads to less bleeding.
This precision also means fewer blood transfusions. It lowers the risk of complications from significant blood loss.
Comparative Incontinence and Impotence Statistics
Studies show robotic prostatectomy patients have lower incontinence and impotence rates. The precise nerve-sparing techniques of robotic technology help preserve urinary and sexual function.
- Lower rates of urinary incontinence
- Improved erectile function preservation
- Better overall sexual function recovery
Recovery Time and Pain Level Differences
Robotic prostatectomy leads to shorter hospital stays and faster recovery. Its minimally invasive nature causes less tissue trauma. This results in less post-operative pain.
Patients usually return to normal activities quicker. Many report less pain and discomfort than with traditional surgery.
The benefits of robotic prostatectomy extend beyond the immediate post-operative period. They improve the quality of life during recovery. By using robotic technology, patients can expect a smoother, more comfortable recovery.
Life Without a Prostate: Long-term Considerations
After a simple robotic prostatectomy, it’s important to know the long-term effects. Living without a prostate affects a person’s quality of life and health.
Hormonal Balance and Possible Changes
The prostate gland’s removal doesn’t directly affect hormones. But, treatments for prostate cancer, like androgen deprivation therapy (ADT), can cause hormonal changes.
Key considerations include:
- Understanding the role of testosterone and its possible suppression
- Managing symptoms from hormonal changes
- Talking to your healthcare provider about other treatment options
Ongoing PSA Monitoring and Cancer Surveillance
After prostatectomy, it’s key to watch Prostate-Specific Antigen (PSA) levels. This helps find any prostate cancer that might come back.
Regular PSA monitoring is vital for catching cancer early. How often you get a PSA test depends on your risk and your doctor’s advice.
PSA monitoring guidelines:
- First PSA test 6-12 weeks after surgery
- Follow-up tests every 6-12 months
- Higher-risk patients might need tests more often
Quality of Life Expectations Years After Surgery
Years after surgery, most people see a big boost in their quality of life. But, some might deal with ongoing side effects.
- Dealing with urinary incontinence and erectile dysfunction
- Keeping a healthy lifestyle with diet and exercise
- Regular check-ups with healthcare providers to watch for cancer return
Life without a prostate means thinking about hormonal balance, PSA monitoring, and quality of life. Knowing these things helps patients manage their health and well-being after surgery.
When to Seek Medical Help Post-Surgery
After a robotic prostatectomy, knowing when to seek medical help is key. Some side effects are normal, but others may mean you need urgent care.
Red Flag Symptoms Requiring Immediate Attention
Some symptoms after robotic prostatectomy need quick medical check-ups. These include:
- Severe pain not managed with prescribed medication
- Heavy bleeding or clots from the surgical site
- Fever above 101.5°F (38.6°C)
- Increasing redness, swelling, or drainage from the incision site
- Difficulty or inability to urinate
- Severe urinary incontinence or persistent leakage
- Signs of infection, such as chills or general malaise
Distinguishing Normal Recovery from Complications
Telling normal recovery symptoms from complications can be tough. Normal symptoms usually get better with time. Complications might show up with new or worsening symptoms.
For example, some urinary incontinence after surgery is normal. But if it doesn’t get better or gets worse, it could be a sign of a problem.
Recommended Follow-up Schedule
Here’s a typical follow-up plan after robotic prostatectomy:
|
Follow-up Time |
Typical Activities |
|---|---|
|
1-2 weeks post-op |
Catheter removal, initial recovery assessment |
|
6-8 weeks post-op |
Assessment of urinary continence, discussion of sexual function recovery |
|
3-6 months post-op |
PSA level check, evaluation of overall recovery progress |
|
1 year post-op |
Long-term outcome assessment, discussion of further follow-up needs |
Following this follow-up schedule is vital for a smooth recovery. If you see any red flag symptoms or have recovery concerns, reach out to your healthcare provider right away.
Minimizing Side Effects: Pre-Surgery Preparations
Getting ready for robotic prostatectomy involves several steps. These steps can greatly affect the outcome and lessen side effects. By preparing well before surgery, patients can lower the chance of complications and make their recovery better.
Physical Conditioning and Pelvic Floor Training
Being physically fit before surgery can help a lot with recovery. Pelvic floor training is key for getting back urinary control after prostate surgery. Start pelvic floor exercises, like Kegel exercises, 4-6 weeks before surgery. This strengthens the muscles that help with urinary control.
Doing regular physical activities, like walking or light cardio, can also boost health. This might lower the chance of problems during and after surgery.
Medication and Supplement Adjustments
It’s very important to talk about all medications and supplements with your doctor before surgery. Some medicines, like blood thinners, might need to be changed or stopped to avoid bleeding.
We also tell patients to stop taking supplements that can cause bleeding, like omega-3 fatty acids, vitamin E, and garlic supplements, for two weeks before surgery.
Nutritional and Lifestyle Optimizations
Eating well before surgery can help with healing and recovery. Eat a diet full of fruits, vegetables, whole grains, and lean proteins. Drinking lots of water is also key.
Quitting smoking is important, as it can slow healing and raise the risk of problems. Also, drinking less alcohol is good, as too much can mess with anesthesia and recovery.
By focusing on these pre-surgery steps, patients can greatly reduce side effects and improve their results after robotic prostatectomy.
Choosing the Right Surgeon to Reduce Complications
Choosing a skilled surgeon is key to avoiding problems after robotic prostatectomy. The surgeon’s experience and the hospital’s quality greatly affect the surgery’s success.
Surgeon Experience and Case Volume Importance
A surgeon’s experience is very important for a successful robotic prostatectomy. Surgeons who do many of these surgeries have better results and fewer problems. Research shows that those with more experience have lower complication rates and fewer hospital readmissions.
Key statistics to consider when evaluating a surgeon’s experience include:
|
Criteria |
High Volume Surgeon |
Low Volume Surgeon |
|---|---|---|
|
Number of Procedures |
>100 cases/year | |
|
Complication Rate |
Lower |
Higher |
|
Recovery Time |
Faster |
Slower |
Critical Questions for Surgical Consultations
When talking to a surgeon, ask important questions to understand their experience and methods. Some key questions are:
- How many robotic prostatectomies have you performed?
- What are your complication and success rates?
- What is your approach to preserving urinary and sexual function?
- How do you handle complications if they arise?
Hospital Quality Metrics and Success Rates
The hospital’s quality is also very important. Quality metrics can show the level of care and success rates. Important metrics include:
- Infection rates
- Readmission rates
- Patient satisfaction scores
- Surgeon and hospital volume
By looking at these factors and asking the right questions, patients can make better choices. This can help avoid complications after robotic prostatectomy.
Conclusion
Robotic prostatectomy is a key surgery for prostate cancer. It has benefits like less blood loss and quicker recovery. But, it also has side effects that patients need to know about. Knowing about side effects like urinary issues, erectile problems, and bowel changes is key. This knowledge helps patients make better choices. Choosing an experienced surgeon can also help reduce these risks. It’s vital for patients to talk about their risks and worries with their doctors. With the right care, many men can get back to their normal lives. They can manage any lasting side effects well. Being well-informed and working with a great medical team is important. This way, patients can get the best from their treatment. They can look forward to a good outcome.
FAQ
What is robotic prostatectomy?
Robotic prostatectomy is a surgery to treat prostate cancer. It uses robotic technology to remove the prostate gland.
What are the immediate side effects after robotic prostatectomy?
Right after surgery, you might feel pain and discomfort. You could also have issues with the urinary catheter. Bleeding or bruising at the incision sites is common too.
How long does it take to recover from robotic prostatectomy?
Recovery time varies. But most people can get back to normal in a few weeks to a few months.
What urinary side effects can occur after prostatectomy?
You might face issues like incontinence or urinary retention. You could also get bladder problems like contractures or strictures.
Can robotic prostatectomy cause sexual dysfunction?
Yes, it can lead to erectile dysfunction and changes in orgasm and ejaculation.
How can urinary side effects be managed?
To manage urinary issues, try pelvic floor therapy, medications, or containment devices. For persistent problems, there are advanced treatments.
What are the treatment options for sexual dysfunction after robotic prostatectomy?
Options include oral meds, injectables, vacuum devices, penile implants, and counseling.
What are the advantages of robotic prostatectomy over traditional open prostatectomy?
Robotic surgery has less blood loss and pain. It also leads to faster recovery times.
Can the prostate be removed without significant long-term effects?
Removing the prostate can affect you, but many men adapt well. They might need to monitor their hormones and PSA levels.
How can I minimize the risk of side effects from robotic prostatectomy?
Prepare before surgery with physical training, pelvic floor exercises, and good nutrition. This can reduce side effects.
What are the signs that I should seek medical help after robotic prostatectomy?
Seek help for severe pain, heavy bleeding, trouble urinating, or signs of infection.
How do I choose the right surgeon for robotic prostatectomy?
Look for a surgeon with lots of experience and good hospital ratings. Their case volume matters too.
What is the importance of follow-up care after robotic prostatectomy?
Follow-up care is key. It helps monitor your recovery, manage side effects, and catch any complications early.
Can I live a normal life without a prostate?
Reference
National Center for Biotechnology Information. Evidence-Based Medical Insight. Retrieved from https://pmc.ncbi.nlm.nih.gov/articles/PMC2900775