Learn the warning signs of skin cancer.

Symptoms and Causes

Understanding the symptoms and causes of skin cancer is essential for anyone who spends time outdoors or has a family history of malignancies. This page is designed for international patients and their families who are seeking clear, reliable information about skin cancer detection and prevention. According to the World Health Organization, more than 1.7 million new cases of skin cancer are diagnosed each year worldwide, making early awareness a critical component of successful treatment. Below, you will find a comprehensive overview that explains the most common signs, underlying risk factors, and the diagnostic pathways available at Liv Hospital.

We will explore the different types of skin cancer, describe how each presents, and discuss the environmental and genetic contributors that increase risk. By the end of this guide, you will be equipped with the knowledge to identify warning signs early and understand when professional evaluation is warranted.

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Types of Skin Cancer and Overview

Skin cancer is not a single disease; it comprises several distinct forms, each with unique biological behavior. The three most prevalent types are:

  • Basal cell carcinoma (BCC): Often appears as a pearly or waxy bump on sun‑exposed areas.
  • Squamous cell carcinoma (SCC): Typically manifests as a firm, red nodule or a flat lesion with a scaly surface.
  • Melanoma: The most aggressive form, presenting as an irregularly shaped mole with varied colors.

Less common variants include Merkel cell carcinoma, dermatofibrosarcoma protuberans, and Kaposi sarcoma. While BCC and SCC rarely spread to distant organs, melanoma can metastasize quickly, underscoring the importance of early detection. All types originate from uncontrolled growth of skin cells, triggered by DNA damage that impairs normal cell regulation.

In clinical practice, physicians categorize skin cancers based on depth of invasion, histological appearance, and molecular markers. These classifications guide treatment choices ranging from surgical excision to targeted systemic therapies. At Liv Hospital, a multidisciplinary team evaluates each case to tailor the most effective approach.

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Recognizing the Symptoms of Skin Cancer

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Identifying the symptoms of skin cancer early can dramatically improve outcomes. While each type has characteristic features, several warning signs are common across the spectrum:

  • A new growth or sore that does not heal within three weeks.
  • Changes in size, shape, or color of an existing mole.
  • Persistent itching, tenderness, or bleeding from a lesion.
  • Surface scaling, crusting, or ulceration.
  • Elevated or raised borders that feel rough to the touch.

Medical professionals often use the ABCDE rule for melanoma detection:

  • Asymmetry – one half does not match the other.
  • Border irregularity – edges are ragged, notched, or blurred.
  • Color variation – multiple shades of brown, black, red, or blue.
  • Diameter – larger than 6 mm (about the size of a pencil eraser).
  • Evolution – any change over time.

Even lesions that seem benign should be examined by a dermatologist if they exhibit any of these characteristics. Regular skin self‑exams, performed monthly, increase the likelihood of catching abnormalities before they progress.

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Causes and Risk Factors Behind Skin Cancer

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Understanding the underlying causes helps patients adopt preventive measures. The primary driver of skin cancer is ultraviolet (UV) radiation, which damages DNA in skin cells. Key risk factors include:

  • Prolonged exposure to sunlight without protection.
  • Use of tanning beds or artificial UV sources.
  • Fair skin, light hair, and a history of sunburns.
  • Family or personal history of skin cancer.
  • Weakened immune system due to medication or disease.
  • Exposure to certain chemicals, such as arsenic or industrial tar.

Genetic mutations, particularly in the BRAF and NRAS genes, increase susceptibility to melanoma. Additionally, chronic skin inflammation or scars can predispose individuals to SCC. While some factors, like genetics, are non‑modifiable, many environmental contributors can be mitigated through lifestyle changes and protective strategies.

Research from leading oncology centers indicates that regular use of broad‑spectrum sunscreen with SPF 30 or higher reduces the incidence of BCC and SCC by up to 40 %. Combining sunscreen with protective clothing, hats, and seeking shade during peak UV hours (10 am–4 pm) forms a comprehensive defense against harmful radiation.

Linking specific symptoms to their underlying causes enables more precise risk assessment. The table below summarizes common presentations, associated risk factors, and recommended actions.

Symptom

Likely Cause / Risk Factor

Suggested Action

Pearly bump on the nose

Basal cell carcinoma; chronic sun exposure

Schedule a dermatologist appointment for biopsy

Scaly red plaque on forearm

Squamous cell carcinoma; history of burns

Request dermoscopic evaluation and possible excision

Irregular, multicolored mole on back

Melanoma; genetic predisposition, intermittent intense UV

Immediate full‑body skin check; consider sentinel node assessment

Persistent ulcer that won’t heal

Advanced SCC or melanoma; immunosuppression

Urgent imaging and multidisciplinary oncology referral

By recognizing how UV damage, genetic mutations, and immune status manifest on the skin, patients can prioritize timely medical review. Early intervention not only simplifies treatment but also improves cosmetic outcomes.

Diagnostic Tests and When to Seek Medical Attention

When a suspicious lesion is identified, clinicians employ several diagnostic tests to confirm malignancy and stage the disease:

  • Dermoscopic examination: A handheld device that magnifies skin structures, revealing patterns invisible to the naked eye.
  • Skin biopsy: The definitive test, ranging from shave, punch, or excisional techniques, examined histologically.
  • Sentinel lymph node biopsy: Used for melanoma to assess spread to regional lymph nodes.
  • Imaging studies (CT, MRI, PET): Required when there is suspicion of metastasis or deep tissue involvement.
  • Genetic testing: Identifies mutations such as BRAF V600E that guide targeted therapy.

Patients should seek professional evaluation promptly if any of the following occur:

  • A new growth appears or an existing mole changes.
  • The lesion bleeds, itches, or becomes painful.
  • There is a family history of melanoma or other skin cancers.
  • You have experienced multiple severe sunburns, especially in childhood.

Liv Hospital’s oncology department offers state‑of‑the‑art diagnostic facilities, including digital dermoscopy and molecular pathology, ensuring accurate staging and personalized treatment planning.

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Why Choose Liv Hospital?

Liv Hospital is a JCI‑accredited, internationally recognized medical center in Istanbul, dedicated to providing comprehensive cancer care for patients worldwide. Our multidisciplinary teams combine expertise in surgical oncology, dermatology, radiology, and targeted therapies, delivering coordinated treatment pathways. International patients benefit from 360‑degree support, including appointment coordination, airport transfers, interpreter services, and comfortable accommodation options, allowing them to focus on recovery.

Take the First Step Toward Early Detection

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Protect your health by scheduling a professional skin assessment today. Contact Liv Hospital’s international patient office to arrange a consultation with our skin cancer specialists and receive personalized guidance on prevention and treatment.

30 Years of
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With patients from across the globe, we bring over three decades of medical

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FREQUENTLY ASKED QUESTIONS

What are the most common types of skin cancer?

Skin cancer includes several distinct forms. Basal cell carcinoma (BCC) usually appears as a pearly bump on sun‑exposed skin. Squamous cell carcinoma (SCC) often shows as a firm, red nodule or a scaly plaque. Melanoma is the most aggressive type, presenting as an irregular, multicolored mole. Less common variants such as Merkel cell carcinoma also exist, but BCC, SCC, and melanoma account for the majority of cases worldwide.

Early signs include a new lesion that does not heal within three weeks, changes in size, shape, or color of an existing mole, persistent itching, tenderness, bleeding, scaling, crusting, or ulceration. For melanoma, the ABCDE rule (Asymmetry, Border irregularity, Color variation, Diameter >6 mm, Evolution) helps identify suspicious lesions. Regular self‑exams and prompt dermatologist visits improve early detection.

The primary cause is ultraviolet (UV) radiation from sunlight or tanning beds, which damages DNA in skin cells. Additional risk factors include having fair skin, light hair, a history of severe sunburns, a personal or family history of skin cancer, immunosuppression, and exposure to carcinogenic chemicals such as arsenic. Genetic mutations (e.g., BRAF, NRAS) also increase melanoma risk.

The ABCDE rule is a quick self‑screening tool. Asymmetry means one half of the mole doesn’t match the other. Border irregularity looks for ragged or notched edges. Color variation checks for multiple shades (brown, black, red, blue). Diameter greater than 6 mm (about a pencil eraser) raises concern. Evolution refers to any change over time. Lesions meeting several criteria should be evaluated by a dermatologist.

Regular application of broad‑spectrum sunscreen with SPF 30 or higher can cut the incidence of basal and squamous cell carcinomas by up to 40 %. Complement sunscreen with protective clothing, wide‑brim hats, and sunglasses. Seek shade between 10 am and 4 pm, avoid tanning beds, and perform monthly self‑exams. For high‑risk individuals, regular dermatologic check‑ups are essential.

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