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Overview
What Is Bowen Disease?
Bowen disease is an early form of skin cancer in which abnormal cells are found in the epidermis, the outermost layer of skin. The cells have not usually grown into deeper skin at this stage, but the area still needs medical assessment and treatment. It most often affects adults over 60, particularly on sun-exposed areas such as the face, hands, arms and lower legs. Bowen’s disease, also called Bowens skin cancer in some patient information, is usually treatable when found early.
Symptoms
Symptoms and What Bowen Disease Looks Like
Bowen disease may look like a minor skin problem and can be mistaken for eczema, psoriasis or an injury that is taking a long time to heal. It often develops slowly as a patch that changes gradually over months or years. The appearance can vary with skin tone and with the area of the body affected.
- A persistent, scaly patch (keratotic plaque)
- A sharply defined red or brown patch
- Crusting on the surface of the patch
- Bleeding from the affected area
- Tenderness or soreness
- Itching of the patch
- A sore that does not heal
Causes
Causes of Bowen Disease
Bowen disease develops when accumulated DNA damage causes cells in the epidermis to grow abnormally. Ultraviolet radiation from sunlight is the most common driver, although other exposures and health conditions can contribute. Bowen disease is not contagious and cannot be spread through touch or close contact.
- Long-term or repeated exposure to sunlight can damage the DNA of epidermal cells.
- Artificial ultraviolet light from tanning beds can also contribute to abnormal cell changes.
- Past arsenic exposure may increase risk, particularly in people with relevant occupational or medical exposure.
- Human papillomavirus (HPV) may be linked with some lesions, especially in certain body sites.
- Immune suppression can reduce the body’s ability to control abnormal skin cells.
Risk Factors
Risk Factors for Bowen Disease
Factors that cannot usually be changed
- Increasing age, especially being an older adult
- Light or fair skin that burns easily
- A previous skin cancer or precancerous skin lesion
- Long-term immune suppression from illness or medication
- Previous radiation treatment or arsenic exposure
Factors that can be reduced
- Repeated unprotected exposure to sunlight
- Using tanning beds or other artificial tanning equipment
- Failing to protect exposed or vulnerable skin during outdoor activities
Complications
Complications of Bowen Disease
Bowen disease is usually slow-growing and treatable, but an untreated lesion can enlarge or become irritated and bleed. It can return after treatment, and some people develop additional precancerous or cancerous lesions elsewhere on the skin. In a small proportion of cases, abnormal cells can progress to invasive squamous cell carcinoma, which grows into deeper layers of skin.
- Local discomfort, irritation or bleeding
- Recurrence of the treated lesion
- Additional precancerous or cancerous lesions elsewhere on the skin
- Progression to invasive squamous cell carcinoma
Diagnosis
How Bowen Disease Is Diagnosed
A clinician examines the skin patch and considers its size, border, surface, location and how long it has been present. They may ask whether it has changed, bled, crusted or become painful. Because eczema, psoriasis, infection and other skin cancers can look similar, these conditions need to be distinguished before treatment is chosen.
Skin biopsy
A skin biopsy removes a small sample of the affected area for examination in a laboratory. Local anaesthetic is used to numb the skin, and the clinician will explain how to keep the wound clean and covered while it heals. The results can confirm whether abnormal cells are confined to the epidermis or whether invasive cancer is present, helping guide treatment options and follow-up.
Treatment Options
Treatment Options for Bowen Disease
Treatment aims to remove or destroy the abnormal cells. A dermatologist may recommend one treatment or combine approaches based on the lesion’s size, number, location, depth, recurrence history and your general health. The options below are examples; the most suitable choice should be discussed with your healthcare team.
| Treatment | How it works | Common uses | What to expect |
|---|---|---|---|
| Excision | Cuts out the lesion with a margin of surrounding skin | Useful when complete removal and tissue examination are priorities | Requires a wound to heal and may leave a scar |
| Cryotherapy | Freezes and destroys abnormal cells | May suit selected small or superficial lesions | Can blister, crust, change pigment, or scar during healing |
| Topical 5-fluorouracil or imiquimod | Applies medicine or stimulates an immune response in abnormal surface cells | May suit superficial or multiple lesions | Requires repeated applications and can cause marked inflammation |
| Curettage and cautery | Scrapes away abnormal tissue and seals the area with heat | May suit selected accessible lesions | Leaves a healing wound and may cause scarring or pigment change |
| Photodynamic therapy | Uses a light-sensitive medicine activated by a specific light | May be considered for suitable superficial lesions | Can cause pain, redness, crusting, and temporary light sensitivity |
| Radiotherapy | Uses focused radiation to damage abnormal cells | May be considered when surgery is unsuitable or for selected difficult-to-treat lesions | Treatment is given in planned sessions and can cause skin irritation |
Follow your wound-care instructions and protect treated skin from ultraviolet light while it heals. Complete any prescribed topical course, even if the area becomes inflamed, unless your clinician tells you to stop. Attend review if the area does not heal, returns, or develops new changes. Cryotherapy for Bowen’s disease is one option for selected lesions, but it is not suitable for every site or situation.
Prevention
Can Bowen Disease Be Prevented?
- Use broad-spectrum sunscreen on exposed skin as directed.
- Wear protective clothing and a wide-brimmed hat in strong sunlight.
- Seek shade, especially when ultraviolet levels are high.
- Avoid tanning beds.
- Avoid intentional tanning.
- Examine your skin regularly for new or changing patches.
Sun protection lowers ultraviolet damage but cannot eliminate the risk of Bowen disease, particularly when past exposure or other risk factors are involved. If you have had Bowen disease or another skin cancer, follow your clinician’s plan for regular skin checks and report new or changing areas.
Outlook and Prognosis
Outlook and Prognosis
Bowen disease usually has an excellent outlook when treated. The expected outcome depends on the lesion’s size and location, the treatment used, your immune status, and whether testing finds invasive cancer. Ongoing monitoring remains important even after successful treatment.
- The treated area can recur and may need further assessment or treatment.
- New Bowen disease or other skin lesions may develop elsewhere.
- Treatment can leave a scar or a temporary or permanent change in skin color.
- Progression to invasive squamous cell carcinoma is uncommon but possible.
Check treated areas and the rest of your skin regularly, use sun protection, and attend scheduled dermatology reviews. Follow-up may be especially important after recurrence or for people with immune suppression. Report a new or changing patch rather than waiting for the next routine appointment.
When Should You See a Doctor
When Should You See a Doctor?
When to get help
Have persistent skin changes checked
Arrange a medical assessment for a skin patch or sore that persists, changes, bleeds, crusts, becomes painful, or does not heal. After treatment, contact your clinician if the area returns or healing is delayed.
A primary care clinician, dermatologist or skin cancer service can examine the area and arrange a biopsy when needed. Early assessment does not mean the lesion is definitely cancer, but it helps identify Bowens skin cancer and other conditions while they are easier to treat. The same advice applies if you notice signs described as enfermedad de bowen in Spanish-language health information, including a persistent or changing scaly patch.
Branches
1 topic
Bowen Disease
Dermatology




