Overview

What Is Mitral Stenosis?

Mitral stenosis is a narrowing of the mitral valve, which sits between the heart’s left atrium and left ventricle. This narrowing makes it harder for blood to move forward into the left ventricle, so pressure can build up behind the valve. Rheumatic disease is a common cause in many parts of the world, while age-related calcium buildup and congenital valve problems are other possible causes. Some people have few symptoms at first, but breathing problems and reduced stamina can develop as the valve becomes more restricted.

Symptoms

Mitral Stenosis Symptoms

Mild mitral valve stenosis may cause no noticeable symptoms. Symptoms can become clearer during exercise, pregnancy, an infection, or an irregular heart rhythm, and they may gradually worsen as blood flow becomes more restricted.

  • Shortness of breath, especially with activity or when lying down
  • Reduced exercise tolerance
  • Fatigue
  • Cough
  • Palpitations, or a noticeable heartbeat
  • Swelling in the legs or ankles
  • Coughing up blood (hemoptysis)
  • An abnormal heart sound, such as a murmur, identified by a clinician

Causes

Causes of Mitral Stenosis

Scarring, thickening, or fusion of the mitral valve leaflets can reduce the valve opening and obstruct blood flow from the left atrium to the left ventricle. Calcium deposits can also stiffen the valve or the ring around it. This narrowing is different from mitral incompetence, also called mitral regurgitation, in which the valve leaks instead of opening too narrowly.

  • Rheumatic heart disease after rheumatic fever, known as rheumatic mitral stenosis
  • Age-related calcification of the mitral annulus or valve leaflets
  • Congenital mitral valve abnormalities present from birth
  • Prior chest radiation or inflammatory disease affecting the valve
  • Rare systemic conditions that cause calcium buildup or other valve changes

Risk Factors

Risk Factors for Mitral Stenosis

Less modifiable factors

These include older age, a history of rheumatic fever or rheumatic heart disease, congenital valve abnormalities, prior chest radiation, and some inflammatory conditions. Having family or geographic connections to areas where rheumatic fever remains common may also reflect increased exposure risk.

Preventable or manageable factors

Prompt medical evaluation and treatment of streptococcal throat infections can help prevent rheumatic fever. Managing inflammatory illness and attending follow-up for known mitral valve disease may help identify changes before they cause major complications.

Risk factors for mitral valve disease include age, previous rheumatic fever or rheumatic heart disease, congenital valve abnormalities, prior chest radiation, and inflammatory conditions. Living in or having close connections to regions where rheumatic fever remains common can also increase the likelihood of rheumatic disease. Prompt treatment of streptococcal throat infections can help prevent rheumatic fever and later valvular stenosis.

Complications

Complications of Mitral Stenosis

Complications are more likely when the valve opening becomes severely narrowed or symptoms are not treated. Pressure rising behind the valve can cause congestion in the lungs and eventually strain the right side of the heart. The risk depends on the valve’s structure and blood flow measurements, not symptoms alone.

  • Pulmonary hypertension, or high blood pressure in the lung arteries
  • Atrial fibrillation and other abnormal heart rhythms
  • Blood clots or stroke, particularly when atrial fibrillation is present
  • Heart failure
  • Fluid buildup in the lungs
  • Recurrent breathlessness, cough, or other respiratory symptoms
  • Severity assessed with echocardiography and mitral valve-area measurements rather than symptoms alone

Diagnosis

How Mitral Stenosis Is Diagnosed

Diagnosis begins with a review of symptoms and medical history, followed by a physical examination for a murmur or another abnormal heart sound. Tests then show the valve’s anatomy, how well it opens, and how blood flows through the heart. Echocardiography is the main test for confirming mitral stenosis and grading its severity.

TestWhat it showsWhy it may be used
Transthoracic echocardiographyMitral valve structure, opening, blood flow, chamber size, and pressure effectsMain test to confirm mitral stenosis and assess severity
Transesophageal echocardiographyMore detailed images of the valve and possible clots in the heartUsed when standard echocardiography is unclear or before a procedure
ElectrocardiographyHeart rhythm and electrical activityHelps identify atrial fibrillation or other rhythm problems
Chest imagingHeart size and signs of lung congestionMay help evaluate symptoms and effects on the lungs
Cardiac catheterizationPressures inside the heart and blood vesselsUsed when noninvasive tests are unclear or to plan treatment

Treatment Options

Mitral Stenosis Treatment Options

Mitral stenosis treatment depends on the degree of narrowing, symptoms, valve anatomy, clot risk, heart rhythm, and overall health. Mild or symptom-free disease may be monitored, while medicines can manage fluid buildup, rhythm problems, or clot risk but usually cannot open the narrowed valve. Intervention is considered when stenosis is severe, symptomatic, or causing heart or lung complications.

Balloon Mitral Valvotomy

During balloon mitral valvotomy, a catheter-mounted balloon is guided to the mitral valve and inflated to widen a suitable narrowed opening. It may benefit people whose valve anatomy is favorable and who do not have a clot or other finding that makes the procedure unsafe. Recovery is generally shorter than recovery from open surgery, but bleeding, valve leakage, rhythm problems, clot-related events, or other complications are possible. Follow-up is needed to check whether the valve remains open and whether narrowing returns. Medicines may be used alongside or instead of a procedure to control fluid retention, rhythm problems, or clot risk.

Mitral Valve Repair or Replacement Surgery

Surgery may be considered when the valve is severely damaged, balloon treatment is unsuitable or unsuccessful, or symptoms and heart or lung effects remain significant. Repair preserves the person’s valve by separating fused areas or correcting damaged tissue when possible; replacement removes the valve and inserts a mechanical or tissue valve. Recovery usually takes longer than catheter treatment and includes activity restrictions and cardiac follow-up. A mechanical replacement generally requires lifelong anticoagulation, while tissue valves may have different durability and medication considerations.

Outlook and Prognosis

Outlook and Prognosis for Mitral Stenosis

Mitral stenosis may remain stable for years but can progress, particularly after rheumatic damage or significant calcification. The outlook depends on the degree of narrowing, symptoms, heart rhythm, lung pressure, and complications. Prognosis is generally better with regular monitoring, treatment of rhythm or clot risks, and timely valve intervention when it is indicated.

When Should You See a Doctor

When Should You See a Doctor?

Arrange a medical appointment for unexplained shortness of breath, reduced exercise tolerance, persistent fatigue, palpitations, or swelling in the legs or ankles. You should also seek evaluation if you have a history of rheumatic fever or known valve disease. If you have been diagnosed with mitral stenosis, keep scheduled cardiology visits so changes can be detected and treated.

Seek urgent care

When symptoms may be an emergency

Call emergency services for severe or sudden breathing difficulty, chest pain, fainting, coughing up large amounts of blood, sudden weakness or trouble speaking, or rapidly worsening symptoms. If you are seriously unwell, do not drive yourself.