Human Protein Atlas: 7 Key Features of the Genome Protein Database

Explore the world’s largest genome protein expression atlas – the Human Protein Atlas. Analyze 11,200+ proteins, 50% of human genes, and 10M+ images.

Mustafa Çelik

Magnero Content Team

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Human Protein Atlas: 7 Key Features of the Genome Protein Database 4

We think knowing how our bodies work is key to better health. The uman protein atlas is a top tool for seeing how our cells function in different parts of our body. It has been documenting over 11,200 unique molecular units ever sense it started in 2003.

Scientists use this huge resource to study where important markers are found in our bodies. With more than 10 million high-quality images, we can see how cells act at a single-cell level. This data spans 31 different human tissues, helping us give superior care and insights.

By mixing data from cancer studies and blood tests, we get a full picture of biology. This knowledge lets doctors find new, precise ways to treat diseases with care. We encourage you to dive into these findings to help move medical science forward.

Key Takeaways

Maps the spatial distribution of molecules across human organs and cells.
Includes data on 11,200 unique analyzed units from the start.
Features over 10 million high-resolution images for detailed study.
Covers more than 50 percent of all human coding genes.
Integrates single-cell resolution data from 31 distinct tissue types.
Combines cancer pathology and blood analysis to support clinical research.

What Makes the Human Protein Atlas Essential for Researchers

The Human Protein Atlas is a key tool for scientists studying proteins. It has a huge amount of data on protein expression. This includes information from tissues, organs, cancer, and single-cell RNA sequencing.

This database is a treasure trove for researchers. It helps them see how proteins work and their role in health and disease. It does this by combining data from different sources.

The Human Protein Atlas has detailed info on protein expression in 44 normal human tissue types and 64 different cell lines. This is vital for scientists who want to grasp the complex roles of proteins.

Data Type	Description	Coverage
Tissue Expression Data	Detailed information on protein expression across various tissues	44 normal human tissue types
Cell Line Data	Protein expression analysis in different cell lines	64 different cell lines
Cancer Pathology Data	Information on protein expression in cancerous tissues	17 major cancer types

The Human Protein Atlas gives researchers a wealth of data. This lets them dive deep into protein expression and its role in diseases. It’s a big step forward in understanding human health and disease.

Core Features of the Genome Protein Database

The Human Protein Atlas is a key resource in genomics and proteomics. It has a vast collection of protein data. This makes it essential for researchers.

1. Unprecedented Protein Coverage: Over 11,200 Unique Proteins Analyzed

The Human Protein Atlas has analyzed over 11,200 unique proteins. This unprecedented protein coverage helps researchers understand the human proteome. They can study protein functions and interactions deeply.

2. Massive Visual Documentation: 10 Million Images at Single-Cell Resolution

The Human Protein Atlas has a huge visual dataset. It includes over 10 million images at single-cell resolution. This allows scientists to see protein expression patterns with great detail.

3. Tissue Atlas: Comprehensives Mapping Across 44 Normal Human Tissue Types

The Tissue Atlas is a key part of the Human Protein Atlas. It maps protein expression across 44 normal human tissue types. This atlas helps understand tissue-specific protein functions and their role in health and disease.

Detailed protein expression profiles for each tissue type
Insights into tissue-specific protein functions
A valuable resource for understanding disease mechanisms

4. Cell Atlas: Protein Expression Analysis in 64 Different Cell Lines

The Cell Atlas in the Human Protein Atlas analyzes protein expression in 64 cell lines. It gives a detailed view of protein distribution and function at the cellular level. This is key for studying cellular biology and disease pathology.

The Human Protein Atlas is a powerful tool for advancing our knowledge of the human proteome. Its detailed data and visual documentation help researchers explore new areas in biomedical research. This leads to new therapeutic strategies.

Advanced Data Integration and Specialized Resources

The Human Protein Atlas database stands out for its advanced data integration and specialized resources. It offers researchers a detailed platform for studying complex biological processes.

Several key components boost the database’s capabilities. These include the Pathology Atlas, a platform for integrating data from multiple sources. It also features single-cell RNA sequencing data from various human tissues.

Pathology Atlas: Clinical Outcomes Across 17 Major Cancer Types

The Pathology Atlas is a vital part of the Human Protein Atlas. It shows how gene expression relates to clinical outcomes in 17 major cancers. This knowledge is essential for understanding how gene expression affects cancer prognosis.

Key Features of the Pathology Atlas:

Association of genes with clinical outcomes in cancer
Comprehensive data across 17 major cancer types
Insights into the prognostic value of gene expression

For example, the Pathology Atlas helps researchers see how certain genes affect patient outcomes in different cancers. This information guides research into new cancer treatments.

Cancer Type	Genes Associated with Clinical Outcome	Prognostic Value
Breast Cancer	BRCA1, BRCA2	High
Lung Cancer	EGFR, KRAS	Moderate
Colorectal Cancer	APC, TP53	High

Multi-Source Data Integration Platform

The Human Protein Atlas combines data from many sources. This creates a detailed platform for researchers. It lets them study gene and protein expression in different tissues and cell types.

By combining data from various sources, we can:

Enhance the accuracy of gene expression analysis
Provide a more complete understanding of protein function
Help find new therapeutic targets

Single-Cell RNA Sequencing Data from 31 Human Tissues

The Human Protein Atlas also includes single-cell RNA sequencing data from 31 human tissues. This data helps researchers study gene expression at the cellular level. It offers insights into cellular diversity and its role in disease.

Benefits of Single-Cell RNA Sequencing Data:

Detailed analysis of gene expression at the cellular level
Insights into cellular heterogeneity
Understanding disease mechanisms

Conclusion

The Human Protein Atlas has changed how we see genome protein expression. It covers over 11,200 proteins with detailed visuals and special sub-atlases. This makes it key for research.

It combines data from many sources and includes the Pathology Atlas and single-cell RNA sequencing. This boosts its usefulness.

This atlas gives a full view of protein expression and its role in biology. It helps researchers understand protein function and disease better. As we learn more about genome proteins, the Human Protein Atlas and Protein Atlas will keep being vital.