
Arrhythmia affects millions worldwide, causing significant morbidity and mortality. We understand the concerns and questions that come with a diagnosis, including treatment options. Is surgery truly necessary? Understand the key arrhythmia surgery medical necessity factors for a positive treatment plan.
Understanding the condition and its impact is key. Arrhythmia disrupts the heart’s normal rhythm, potentially leading to severe complications if left untreated. The decision to undergo heart rhythm surgery depends on various factors, including the type and severity of arrhythmia.
We are here to guide you through the process. We aim to provide clarity on whether cardiac arrhythmia surgery is necessary for your specific condition.
Key Takeaways
- Arrhythmia is a serious condition that affects millions worldwide.
- The necessity for surgery depends on the type and severity of arrhythmia.
- Understanding your condition is key to making informed decisions.
- Various factors influence the decision to undergo heart rhythm surgery.
- Seeking professional guidance is essential for determining the best treatment plan.
Understanding Cardiac Arrhythmias

The heart’s rhythm is controlled by a complex system. When this system is disrupted, cardiac arrhythmias can occur. This leads to various health issues. We will explore these conditions to better understand their implications.
Definition and Basic Mechanisms
Cardiac arrhythmias are abnormal heart rhythms. They can be caused by genetics, age, and medical conditions. These irregularities happen when the heart’s electrical system is disrupted.
The basic mechanisms behind cardiac arrhythmias involve changes in the heart’s electrical activity. This can be due to problems with the sinoatrial node, the atrioventricular node, or the ventricular tissue itself. Understanding these mechanisms is key for diagnosing and treating arrhythmias effectively.
Normal Heart Rhythm vs. Arrhythmias
A normal heart rhythm is between 60 to 100 beats per minute. It has a consistent and coordinated pattern. Arrhythmias, on the other hand, have irregularities in heart rate or rhythm.
The difference between a normal heart rhythm and an arrhythmia is critical for treatment. Diagnostic tests like electrocardiograms (ECGs) and Holter monitoring help identify the type and severity of the arrhythmia.
Impact on Quality of Life and Health
Cardiac arrhythmias can significantly impact a patient’s quality of life. Symptoms include palpitations, shortness of breath, fatigue, and dizziness. These symptoms can be intermittent or persistent, affecting daily activities and overall well-being.
Beyond the immediate symptoms, cardiac arrhythmias can have long-term health implications. They can increase the risk of stroke, heart failure, and other cardiovascular complications. Effective management of arrhythmias is essential to mitigate these risks and improve patient outcomes.
Common Types of Arrhythmias

It’s important to know about the different types of arrhythmias. This knowledge helps doctors diagnose and treat them better. Arrhythmias are divided into categories based on their characteristics and where they occur in the heart.
Tachycardias: Atrial Fibrillation, Atrial Flutter, SVT
Tachycardias happen when the heart beats too fast. This is due to an electrical problem in the heart. Atrial fibrillation is the most common, causing irregular heartbeats. It affects millions and can lead to serious problems like stroke if not treated.
Atrial flutter has a fast but regular heartbeat. It’s linked to heart disease and high blood pressure. Supraventricular tachycardia (SVT) makes the heart beat too fast because of electrical issues in the upper heart chambers.
Bradycardias: Sinus Node Dysfunction, Heart Blocks
Bradycardias make the heart beat too slow. Sinus node dysfunction happens when the heart’s pacemaker doesn’t work right, causing a slow heart rate. Heart blocks delay or block electrical signals between heart chambers, leading to a slow heart rate.
These can cause symptoms like tiredness, dizziness, and fainting. In serious cases, a pacemaker might be needed to fix the heart’s rhythm.
Premature Beats and Other Arrhythmias
Premature beats are early electrical impulses that disrupt the heart’s rhythm. They can feel like skipped beats or palpitations. While often harmless, they can signal heart disease in some people.
Other serious arrhythmias include ventricular tachycardia and ventricular fibrillation. These need quick medical help. Knowing the different types helps find the right treatment, which might include medicine, lifestyle changes, or surgery.
Diagnosing Arrhythmias: The First Step Toward Treatment
Diagnosing arrhythmias is the first step to treating them. It involves tests and evaluations to understand the heart’s rhythm. This helps identify any irregularities.
Electrocardiogram (ECG) and Holter Monitoring
An Electrocardiogram (ECG) is a non-invasive test that measures the heart’s electrical activity. It shows the heart’s rhythm and can spot arrhythmia patterns.
But, arrhythmias can be intermittent. A Holter monitor, a portable ECG, records heart activity for 24 to 48 hours. It catches episodes that might not show up on a standard ECG.
Electrophysiology Studies (EPS)
For complex cases, an Electrophysiology Study (EPS) is recommended. EPS uses thin, flexible wires through a vein to the heart to record electrical signals.
This test finds the arrhythmia’s location and type. It helps guide treatment decisions.
Advanced Imaging Techniques
Advanced imaging like echocardiography or cardiac MRI may be used. They assess the heart’s structure and function.
These tests show underlying conditions that might cause the arrhythmia. This includes structural heart defects or damaged heart tissue.
By using these diagnostic methods, we get a full picture of an individual’s arrhythmia. This leads to an effective treatment plan.
Non-Surgical Treatment Approaches
Non-surgical treatments are often the first choice for arrhythmias. They aim to control symptoms and improve life quality. They also help reduce risks linked to arrhythmias.
Medication Options
Medicines are key in managing arrhythmias. Beta-blockers and anti-arrhythmic agents are used to control heart rate and rhythm. Beta-blockers slow the heart rate and reduce its force. Anti-arrhythmic agents help restore a normal rhythm.
The right medicine depends on the arrhythmia type and the patient’s health. For example, beta-blockers are often used for atrial fibrillation to control the ventricular rate.
Lifestyle Modifications
Lifestyle changes are vital in managing arrhythmias. They help reduce symptoms and improve heart health. Key changes include:
- Maintaining a healthy weight
- Engaging in regular physical activity
- Eating a balanced diet rich in fruits, vegetables, and whole grains
- Avoiding stimulants like caffeine and nicotine
- Managing stress through techniques such as meditation or yoga
By making these changes, patients can improve their condition and reduce arrhythmia episodes.
Monitoring and Follow-up
Regular monitoring and follow-up with healthcare providers are essential. This may include:
- Periodic electrocardiograms (ECGs) to assess heart rhythm
- Holter monitoring or event monitoring to track heart activity over time
- Adjusting medications or treatment plans as needed based on the monitoring results
Effective monitoring helps in early detection of any changes. This allows for timely interventions.
Non-surgical treatments offer many effective options for managing arrhythmias. By combining medication, lifestyle changes, and regular monitoring, patients can better control their condition. This improves their quality of life.
When Medications Fail: Progression to Interventional Options
Arrhythmia management often starts with medication. But when this doesn’t work, other treatments are needed. For those with arrhythmias, the first step is usually medication to control heart rhythm. If these don’t work, it’s time to look at other options.
Recognizing Treatment-Resistant Arrhythmias
Treatment-resistant arrhythmias don’t respond to medication or have too many side effects. Identifying this involves watching the patient closely and checking how they react to medication. This might include regular heart tests and tracking symptoms.
Risk Stratification for Patients
After identifying treatment resistance, the next step is risk stratification. This means looking at the patient’s risk of problems from the arrhythmia and treatments. Risk stratification helps decide if more interventional treatments are needed. It considers the arrhythmia type, the patient’s health, and any other health issues.
|
Risk Factor |
Description |
Impact on Decision Making |
|---|---|---|
|
Type of Arrhythmia |
The specific type of arrhythmia, such as atrial fibrillationor ventricular tachycardia. |
Influences the choice of interventional treatment. |
|
Severity of Arrhythmia |
The frequency and duration of arrhythmia episodes. |
Affects the urgency and aggressiveness of the treatment plan. |
|
Comorbid Conditions |
Presence of other health conditions, such as heart disease or diabetes. |
Impacts the overall risk assessment and treatment choices. |
The Decision-Making Process with Your Cardiologist
Deciding on interventional options is a team effort with a cardiologist. This involves talking about the risks and benefits of treatments, considering the patient’s wishes, and choosing the best option. It’s a key step that needs careful thought and clear communication.
In summary, when medication doesn’t work for arrhythmias, it’s time to try other treatments. Recognizing treatment-resistant arrhythmias, assessing risk, and making a decision with a cardiologist are all important steps. They help ensure patients get the right care for their condition.
Arrhythmia Surgery Medical Necessity: Determining Factors
Figuring out if arrhythmia surgery is needed is complex. We look at many factors to decide if it’s necessary.
Clinical Indications for Surgical Intervention
Deciding if surgery is needed depends on several things. These include the type and how bad the arrhythmia is. Also, if symptoms like palpitations or shortness of breath are present. And if other treatments have worked.
For example, people with atrial fibrillation who are feeling bad and haven’t gotten better with medicine might need surgery.
Key clinical indicators include:
- Failure of medical therapy to control symptoms
- Presence of severe symptoms impacting quality of life
- High risk of stroke or other complications
Quality of Life Considerations
How arrhythmias affect a person’s life is very important. We look at how symptoms impact daily life, sleep, and happiness. Surgery might be suggested if arrhythmias really hurt a person’s quality of life, even with the best medicine.
Improving quality of life is a main goal of arrhythmia surgery. It aims to reduce symptoms and lower the risk of serious problems, making patients healthier and happier.
Risk-Benefit Analysis for Individual Patients
Doing a detailed risk-benefit analysis is key for each patient. We compare the good things surgery can do, like making symptoms better and improving life, to the possible bad things, like complications or the arrhythmia coming back.
We think about the patient’s health, any other health issues they might have, and how likely they are to do well with surgery. This helps us make smart choices about surgery.
In the end, the choice to have arrhythmia surgery is made for each person separately. We consider their unique situation and needs.
Minimally Invasive Procedures vs. Traditional Surgery
There are two ways to treat heart arrhythmias: minimally invasive procedures and traditional surgery. Each has its own benefits and risks. The right choice depends on the arrhythmia type, its severity, and the patient’s health.
Catheter Ablation Techniques
Catheter ablation is a less invasive method. It uses energy to destroy bad heart pathways. This method is popular because it works well and has less recovery time than surgery.
Key benefits of catheter ablation include:
- Minimally invasive, reducing the risk of complications
- Shorter recovery times, often allowing patients to return home the same day
- Less pain compared to traditional surgery
Pacemakers and Implantable Cardioverter-Defibrillators (ICDs)
Pacemakers and ICDs are small devices implanted to control heart rhythms. They don’t cure arrhythmias but manage symptoms and prevent serious issues.
Pacemakers treat slow heart rates by keeping the rhythm steady. ICDs prevent sudden death from bad heart rhythms by shocking the heart when needed.
Comparing Recovery Times and Outcomes
Recovery times and outcomes differ between minimally invasive procedures and traditional surgery. Procedures like catheter ablation usually have shorter recovery times and fewer complications.
A study showed catheter ablation has shorter hospital stays and fewer complications than traditional surgery for arrhythmias.
“The advancement in catheter ablation techniques has significantly improved the treatment landscape for arrhythmia patients, providing a safer and less invasive option compared to traditional surgery.”
A Cardiologist
Choosing between minimally invasive procedures and traditional surgery should be discussed with a healthcare provider. It depends on the individual’s condition and health.
Catheter Ablation: A Common Surgical Approach
Catheter ablation is a new way to treat some heart problems. It uses a thin tube to fix the heart’s electrical issues. This method is less invasive than old surgeries.
How Ablation Works to Correct Arrhythmias
To start, a doctor puts a catheter through a leg vein. They use special images to find the heart spot causing the problem. Then, they use the catheter to destroy the bad tissue.
Radiofrequency ablation is often used. It sends radio waves to make a mark on the heart. This stops the bad electrical signals.
Success Rates for Different Arrhythmia Types
How well catheter ablation works depends on the heart issue. For example, atrial fibrillation and atrial flutter have different success rates. This is different from other heart rhythm problems.
- SVTs can be fixed in 90% or more of cases with just one treatment.
- Fixing atrial fibrillation can take more tries and has a less certain success rate.
Potential Complications and Limitations
Catheter ablation is usually safe, but it can have risks. These include bleeding, infection, and damage to the heart or blood vessels. Cardiac tamponade is a rare but serious issue.
There are also limits to catheter ablation. The problem might come back, and you might need more treatments. Who you choose to do the procedure and their skill matter a lot for success.
Surgical Maze Procedure for Atrial Fibrillation
Treating atrial fibrillation with the surgical maze procedure requires a deep understanding of the heart’s electrical pathways. Atrial fibrillation is a common and complex heart rhythm disorder. It can greatly affect a patient’s quality of life. The surgical maze procedure aims to restore a normal heart rhythm.
Traditional Cox-Maze Procedure
The Cox-Maze procedure is a surgical method that creates scar tissue in the heart. This scar tissue directs electrical impulses in a normal way. Introduced in the late 1980s, it has been improved to be more effective and less complex.
During the procedure, precise incisions are made in the heart. These incisions are then closed, creating scar tissue. This scar tissue acts as a barrier to abnormal electrical impulses. The goal is to isolate arrhythmia sources and guide the heart’s rhythm back to normal.
Mini-Maze and Hybrid Approaches
Less invasive versions of the maze procedure have been developed, like the mini-Maze. These newer techniques use smaller incisions and advanced ablation technologies. They aim to achieve similar results with fewer complications and a quicker recovery.
Hybrid approaches combine surgical and catheter-based techniques to treat atrial fibrillation. These methods offer a more tailored treatment plan. They leverage the strengths of both surgical and electrophysiological expertise.
Candidates for Maze Procedures
Not all patients with atrial fibrillation are good candidates for the maze procedure. The selection criteria include the type and duration of atrial fibrillation, other heart diseases, and overall health. Patients who have failed or cannot tolerate anti-arrhythmic medications, or those undergoing other cardiac surgeries, may benefit from the maze procedure.
The surgical maze procedure is a valuable treatment option for selected patients with atrial fibrillation. It is important for patients to consult with their cardiologist or cardiac surgeon to determine the best treatment plan.
Device Implantation Procedures
Device implantation procedures have greatly improved life for those with heart rhythm issues. These procedures put devices in the body to control the heartbeat. This ensures it stays in a normal rhythm.
Pacemaker Implantation: Process and Recovery
Pacemaker implantation is a common treatment for arrhythmias, like slow heart rates. A small incision is made in the chest. Then, the pacemaker leads are guided into the heart using X-ray imaging.
The pacemaker generator is placed under the skin after that. Recovery from pacemaker implantation is generally quick. Most patients can get back to normal activities in a few days.
It’s important to follow the post-procedure instructions given by the healthcare team. This ensures proper healing and reduces the risk of complications.
Implantable Cardioverter-Defibrillators (ICDs)
ICDs are advanced devices that prevent sudden cardiac death. They deliver an electric shock when they detect dangerous arrhythmias. The implantation process for ICDs is similar to that of pacemakers. ICDs are recommended for those at higher risk of ventricular arrhythmias.
ICDs also offer pacing functions like pacemakers. This makes them a versatile treatment for different arrhythmias.
Cardiac Resynchronization Therapy (CRT)
CRT treats heart failure by coordinating the left and right ventricles. It’s very helpful for patients with certain heart failure types and left bundle branch block.
|
Therapy |
Description |
Benefits |
|---|---|---|
|
Pacemaker Implantation |
Regulates heart rate |
Improves heart rhythm, reduces symptoms |
|
ICDs |
Prevents sudden cardiac death |
Life-saving, provides pacing functions |
|
CRT |
Resynchronizes ventricular beating |
Improves heart function, reduces heart failure symptoms |
Each device implantation procedure has its own use, benefits, and risks. The choice of device and whether to implant it depends on the patient’s needs and clinical guidelines.
Risks and Complications of Arrhythmia Surgery
Choosing to have arrhythmia surgery means looking at the good and bad sides of it. Like any surgery, it has risks that can be short-term or long-term.
Short-term Surgical Risks
Right after surgery, you might face bleeding, infection, or stroke. These are common risks that doctors watch for closely. Following your doctor’s advice after surgery is key to avoiding these problems.
Also, some people react badly to anesthesia. It’s important to tell the anesthesiologist about your health and any allergies you have. This can help lower this risk.
Long-term Complications and Management
Long-term, you might face arrhythmias coming back, needing a pacemaker, or other issues with devices. Seeing your cardiologist regularly is important for catching and managing these problems early.
Some people might see changes in their heart function or other heart issues after surgery. Keeping an eye on these and adjusting treatment plans as needed is important.
Balancing Risks Against Benefits
When thinking about arrhythmia surgery, weighing the risks against the benefits is key. For many, the better quality of life and fewer symptoms are worth it. Talking it over with your doctor can help figure out if surgery is right for you.
Knowing about the risks and complications of arrhythmia surgery helps patients make better choices. Working with doctors, patients can find the best way to treat their arrhythmia and get good results.
Recovery and Rehabilitation After Arrhythmia Surgery
Recovery and rehabilitation are key after arrhythmia surgery. They need careful watching and support. A good plan for post-operative care is vital for the best results.
Immediate Post-Operative Care
Right after surgery, patients stay in a recovery unit or ICU. This is to watch for any problems or bad reactions. “The first 24 to 48 hours are very important,” says a top cardiothoracic surgeon. “This is when the risk of problems is highest.”
Medical staff keep an eye on vital signs, manage pain, and stop infections.
Key aspects of immediate post-operative care include:
- Continuous monitoring of heart rhythm and vital signs
- Pain management through medication and other interventions
- Prevention and early detection of possible complications
- Gradual mobilization to prevent blood clots and promote circulation
Long-term Recovery Timeline
The recovery time after arrhythmia surgery varies. It depends on the surgery type, the patient’s health, and following instructions. Usually, it takes weeks to months to fully recover.
A typical recovery timeline might look like this:
- 1-2 weeks: Return to light activities and normal daily routines
- 2-6 weeks: Gradually increase physical activity, including exercise
- 6-12 weeks: Resume more strenuous activities, including heavy lifting and bending
Cardiac Rehabilitation Programs
Cardiac rehabilitation programs are very important after arrhythmia surgery. They help improve heart health, reduce symptoms, and boost well-being. They include exercise, education, and lifestyle advice.
“Cardiac rehabilitation is a key part of recovery,” says a cardiologist. “It helps patients regain strength, improve heart health, and lower the risk of future heart problems.”
By adding these elements to their recovery plan, patients can get the best results. This improves their life quality after surgery.
Special Considerations for Different Patient Populations
When planning arrhythmia surgery, we must think about the special needs of each patient group. Arrhythmia treatment is complex and needs a personalized approach. This ensures the treatment meets the specific needs of various patients.
Pediatric Patients with Arrhythmias
Pediatric patients face unique challenges in arrhythmia treatment. Their small size and developing bodies require special care. Surgical techniques and device therapies must be adapted to accommodate their needs.
For example, leadless pacemakers or devices for smaller bodies are becoming more common. We also need to consider the long-term effects of treatment in children. A study in the Journal of the American College of Cardiology shows the importance of long-term follow-up in kids with arrhythmia surgery.
|
Consideration |
Pediatric Patients |
Adult Patients |
|---|---|---|
|
Device Therapy |
Adapted devices for smaller sizes |
Standard pacemakers and ICDs |
|
Surgical Approach |
Modified techniques for smaller anatomy |
Standard surgical ablation techniques |
|
Long-term Care |
Extended follow-up into adulthood |
Standard follow-up protocols |
Elderly Patients and Surgical Risk
Elderly patients often have more health issues that make surgery riskier. Careful risk stratification is essential to determine the most appropriate treatment strategy. A team of experts assesses the patient’s health and the surgery’s benefits.
A cardiologist notes, “The decision to operate on elderly patients with arrhythmias is a delicate balance. It considers the benefits and risks of their health conditions.”
“Age alone is not a contraindication for arrhythmia surgery, but it is a factor that significantly influences our decision-making process.”
A Cardiologist
Patients with Multiple Comorbidities
Patients with many health issues face a big challenge in managing arrhythmias. A thorough assessment of their health is key to finding the best treatment plan. This might involve treating other health conditions at the same time.
We take a holistic approach for patients with many health issues. We consider how surgery fits into their overall health care. This includes improving their medical care and lifestyle to lower surgery risks.
By understanding the unique needs of different patient groups, we can offer more effective and personalized care for those undergoing arrhythmia surgery.
Emerging Technologies and Future Directions
The field of cardiology is seeing big changes in treating arrhythmias thanks to new technologies. We’re pushing the limits of what’s possible, leading to new ways to help patients.
Advances in Mapping and Ablation Technologies
High-resolution mapping systems are now giving us detailed views of the heart’s electrical activity. This helps doctors find and treat arrhythmias more accurately.
New ablation technologies are making it possible to create stronger, lasting lesions. This means fewer chances of arrhythmias coming back after treatment.
|
Technology |
Description |
Benefits |
|---|---|---|
|
High-Resolution Mapping |
Detailed 3D visualization of heart’s electrical activity |
More precise identification and treatment of arrhythmias |
|
Advanced Ablation |
More effective and durable lesions |
Reduced risk of recurrence |
Leadless Pacemakers and Subcutaneous ICDs
Leadless pacemakers and subcutaneous ICDs are big steps forward. They aim to cut down on problems linked to traditional devices.
- Leadless pacemakers are tiny and don’t need leads, cutting down on complications.
- Subcutaneous ICDs are placed under the skin, avoiding the need for leads.
Gene and Cell Therapies for Arrhythmias
Gene and cell therapies are being looked at for treating arrhythmias. They aim to fix the root causes of arrhythmias, leading to better, longer-lasting results.
Gene therapy is being studied to change the heart’s electrical properties. Cell therapy is being explored to repair or replace damaged heart tissue. These are early days, but they show great promise for the future.
Conclusion: Making an Informed Decision About Arrhythmia Surgery
Arrhythmia surgery is a complex treatment for heart rhythm disorders. It requires careful thought about many factors. These include the type and severity of the arrhythmia, overall health, and personal preferences.
To make a good choice, patients need to know the risks and benefits of surgery. They should understand the different surgical methods, like catheter ablation and device implantation. They also need to know about possible complications and the recovery process.
By talking to a skilled cardiologist and considering all options, patients can make a choice that fits their needs. The main goal of surgery is to improve life quality and lower the risk of heart rhythm disorder complications.
As medical technology gets better, new treatments for arrhythmia will come. Patients can stay updated and work with a knowledgeable team. This way, they can make the best choice for their heart health.
FAQ
What is arrhythmia, and how does it affect the heart?
Arrhythmia is when your heartbeat is not regular. It can happen for many reasons, like bad electrical signals in the heart. It can make you feel like your heart is skipping beats, make it hard to breathe, and make you tired. It can really affect your health and how you feel every day.
What are the different types of arrhythmias, and how are they diagnosed?
There are many kinds of arrhythmias, like fast or slow heartbeats and early heartbeats. Doctors use tests like electrocardiograms (ECG) and Holter monitors to find out what kind you have. They also do electrophysiology studies(EPS) to see why it’s happening.
What are the treatment options for arrhythmias, and when is surgery necessary?
Doctors can treat arrhythmias with medicine, changes in your lifestyle, and regular check-ups. Sometimes, surgery is needed if medicine doesn’t work or if your symptoms are bad.
What is catheter ablation, and how is it used to treat arrhythmias?
Catheter ablation is a small procedure that uses energy to fix bad heart signals. It’s used for fast heartbeats and other arrhythmias. It’s a way to treat these problems without big surgery.
What is the surgical maze procedure, and who is a candidate for this surgery?
The maze procedure is surgery for fast heartbeats. It makes scar tissue in the heart to stop bad signals. It’s for people with bad fast heartbeats that don’t get better with other treatments.
What are the risks and complications associated with arrhythmia surgery?
Surgery for arrhythmias can have risks like bleeding and infection. There’s also a chance you might need a pacemaker or have the problem come back. Always talk to your doctor about these risks.
How do I prepare for arrhythmia surgery, and what can I expect during recovery?
Before surgery, you’ll have lots of tests and talks with doctors. After, you’ll stay in the hospital a few days. You might also join a cardiac rehab program to get stronger.
Are there any emerging technologies or future directions in the treatment of arrhythmias?
Yes, new tech is coming for arrhythmia treatment. This includes better mapping and ablation tools, tiny pacemakers, and gene therapies. These could make treatments better and safer.
How do I determine if arrhythmia surgery is right for me?
To decide if surgery is right, talk to your doctor and surgeon. They’ll look at your health, symptoms, and what you’ve tried before. It’s important to understand the risks and benefits.
What are the benefits of arrhythmia surgery, and how can it improve my quality of life?
Surgery can make your heart work better and reduce symptoms. It can also lower the chance of serious problems. Knowing the good and bad can help you choose the best treatment for you.
National Center for Biotechnology Information. Evidence-Based Medical Insight. Retrieved from https://pubmed.ncbi.nlm.nih.gov/38286206/
National Center for Biotechnology Information. Evidence-Based Medical Insight. Retrieved from https://pubmed.ncbi.nlm.nih.gov/38286206/