Sharp What Are The Disadvantages Of Minimally Invasive Surgery Disadvantages?

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Sharp What Are The Disadvantages Of Minimally Invasive Surgery Disadvantages?
Sharp What Are The Disadvantages Of Minimally Invasive Surgery Disadvantages? 4

Nearly 70% of surgical procedures now use minimally invasive techniques. This has changed the medical world by cutting down on recovery time and scarring. But, it’s key to know the possible risks and complications that come with these methods. Listing what are the disadvantages of minimally invasive surgery and discussing potential minimally invasive surgery disadvantages (e.g., steep learning curve, cost).

Minimally invasive surgery has many benefits. Yet, it’s also important to know its downsides before picking a treatment. We aim to give a full view of what to expect from these disadvantages.

Key Takeaways

  • Understanding the possible risks of minimally invasive procedures.
  • Recognizing the complications linked to modern surgery.
  • The importance of being informed before choosing a treatment option.
  • Overview of the possible downsides of minimally invasive techniques.
  • Factors to consider when evaluating surgical procedures.

Understanding Minimally Invasive Surgery

Sharp What Are The Disadvantages Of Minimally Invasive Surgery Disadvantages?
Sharp What Are The Disadvantages Of Minimally Invasive Surgery Disadvantages? 5

Minimally invasive surgery aims to fix problems with little harm to the body. It’s popular because it can make recovery faster, leave less scar, and lower risks compared to open surgery.

Definition and Common Techniques

This surgery uses new tech and tools through small cuts, usually under 1 cm. It includes laparoscopy for the belly and arthroscopy for joints. These methods use scopes with cameras and lights for clear views.

The Rise in Popularity of Minimally Invasive Procedures

More people are choosing minimally invasive surgery. This is thanks to better tech, like imaging and tools. It means less time in the hospital and quicker healing.

Procedure

Traditional Recovery Time

Minimally Invasive Recovery Time

Gallbladder Removal

4-6 weeks

1-2 weeks

Hernia Repair

3-4 weeks

1-2 weeks

General Benefits as Context

Knowing the good sides of minimally invasive surgery helps us see its downsides. It causes less damage, hurts less, and you get home sooner. These points make it a favorite among patients and doctors.

Understanding both the good and bad of minimally invasive surgery helps patients choose wisely. As we look at its downsides, remember its benefits and risks.

Minimally Invasive Surgery Disadvantages: An Overview

Sharp What Are The Disadvantages Of Minimally Invasive Surgery Disadvantages?
Sharp What Are The Disadvantages Of Minimally Invasive Surgery Disadvantages? 6

Exploring minimally invasive surgery, we find its limits. This method has changed medicine for the better. Yet, it’s key to know its downsides.

Common Misconceptions About “Minimally Invasive”

The term “minimally invasive” is often misunderstood. It’s not completely safe or risk-free. Minimally invasive surgery uses smaller cuts than traditional surgery. But, it also has big risks and complications.

Many think these surgeries are simpler. But, they can be very challenging. They need special skills and training.

Categories of Possible Drawbacks

The downsides of minimally invasive surgery fall into several areas:

  • Technical Limitations: Issues with seeing, moving, and getting feedback.
  • Surgeon-Related Factors: Differences in skill, learning curve, and need for training.
  • Patient-Related Factors: Issues with body shape, existing health problems, and anatomy.
  • Equipment-Related Issues: Problems with tools, reliance on technology, and system failures.

Risk-Benefit Assessment Framework

To decide if minimally invasive surgery is right for a patient, we use a detailed framework. It looks at:

  1. The patient’s health and any existing conditions.
  2. The surgery’s complexity and risks.
  3. The surgeon’s experience with these techniques.
  4. The availability and dependability of needed tools and tech.

This framework helps us choose the best approach for each patient. It weighs the benefits against the risks.

Technical Limitations of Minimally Invasive Procedures

Minimally invasive procedures have many benefits. Yet, they come with technical drawbacks. These procedures require a lot of skill and precision. Surgeons face several challenges.

Restricted Field of Vision

One big issue is the limited view. In open surgery, surgeons see everything clearly. But, in minimally invasive surgery, they use cameras and monitors. This limits their view.

This limited view makes it hard to see and work with complex parts of the body. Surgeons use high-definition images and control the camera carefully to get around this problem.

Limited Range of Motion and Tactile Feedback

These procedures also limit how much surgeons can move and feel. Long instruments through small cuts make it hard to work with tissue. It’s like trying to do a puzzle with long arms.

Also, not feeling the tissue directly makes it tough to know its texture and tension. This is important for making accurate surgical decisions.

Challenges with Depth Perception

Seeing depth is another big challenge. The camera’s two-dimensional view makes judging distances hard. It’s like trying to see in 3D with only one eye.

Workspace Constraints

Working in a small space is another issue. Long instruments through small cuts can be tiring. It can also make it harder to stay precise over time.

The table below shows the main technical challenges of minimally invasive procedures and their effects:

Technical Limitation

Description

Potential Impact

Restricted Field of Vision

Limited visual perspective due to camera and monitor reliance

Increased risk of complications, difficulty in navigating complex anatomy

Limited Range of Motion

Restricted manipulation of tissue and maneuverability

Difficulty in performing complex procedures, potentially longer surgery times

Reduced Tactile Feedback

Lack of direct feedback on tissue characteristics

Difficulty in assessing tissue texture, tension, and other critical factors

Challenges with Depth Perception

Difficulty in judging distances and depths

Potential for inaccurate dissections or injuries to surrounding structures

Workspace Constraints

Ergonomic challenges due to operating through small incisions

Surgeon fatigue, decreased precision over time

It’s important for surgeons to know these challenges. Patients should also understand the possible difficulties with minimally invasive procedures.

Surgeon Experience and Learning Curve Issues

Surgeon experience is key to the success of minimally invasive procedures. These surgeries are complex, needing a lot of skill and precision.

Specialized Training Requirements

Surgeons must get specialized training for these surgeries. This training helps them avoid complications and improve patient results.

  • Hands-on training with experienced surgeons
  • Simulation-based training for practicing techniques
  • Continuous education on the latest advancements

Skill Disparities Among Surgeons

There are big disparities in skill levels among surgeons doing minimally invasive surgery. These differences come from training, experience, and natural talent.

To fix these issues, we suggest:

  1. Standardized training programs
  2. Mentorship opportunities
  3. Regular assessment of surgeon competencies

Volume-Outcome Relationship

The volume-outcome relationship shows that more surgeries lead to better results. This highlights the need for surgeons to keep practicing.

Understanding the role of surgeon experience helps us improve minimally invasive surgery. We can make these surgeries safer and more effective by addressing the learning curve challenges.

Extended Operation Time Concerns

Extended operation times in minimally invasive surgeries have raised several concerns among medical professionals. These procedures offer many benefits but can also lead to complications. These complications need careful management.

One major concern is the impact of prolonged anesthesia exposure. Anesthesia is vital for pain management but carries risks. The longer a patient is under anesthesia, the higher the risk of respiratory and cardiac complications.

Impact of Longer Anesthesia Exposure

Prolonged anesthesia exposure can lead to several issues, including:

  • Respiratory complications, such as atelectasis and pneumonia
  • Cardiac issues, including arrhythmias and myocardial infarction
  • Post-operative nausea and vomiting

To mitigate these risks, anesthesiologists and surgeons work together. They monitor patients closely and adjust anesthesia levels as needed. Advanced anesthesia delivery systems and monitoring technologies play a key role in minimizing these risks.

Fatigue-Related Complications

Extended operation times also raise concerns about fatigue-related complications. Surgeons and operating room staff must maintain high levels of concentration and precision. As operation times stretch, the risk of errors due to fatigue increases.

To address this, many hospitals have implemented policies to manage surgeon fatigue. These include:

  1. Regular breaks during long procedures
  2. Team-based approaches to share the workload
  3. Enhanced training to improve efficiency and reduce mental strain

Efficiency vs. Safety Considerations

Balancing efficiency with safety is critical in managing extended operation times. It is essential to complete the procedure efficiently while prioritizing safety. Surgeons and their teams must be vigilant in monitoring for complications and adapt their approach as needed.

Strategies to enhance efficiency while maintaining safety include:

  • Optimizing surgical techniques through continuous training and practice
  • Improving patient monitoring to quickly identify and address any issues
  • Streamlining the surgical workflow to reduce unnecessary delays

By understanding the limitations of minimally invasive techniques and the adverse effects of minimally invasive surgery, we can better navigate the challenges of extended operation times. Advanced technology, careful patient monitoring, and a commitment to safety help minimize risks and maximize benefits.

Equipment-Related Complications and Failures

When we talk about minimally invasive surgery, we must consider the equipment’s role. The use of complex tools in these surgeries brings risks that can affect patient results.

Instrument Malfunctions

One big worry is instrument malfunctions during surgery. These can be simple mechanical problems or more serious issues with precision. It’s key to keep all tools in good shape and check them often to lower these risks.

Technology Dependence Risks

Minimally invasive surgery relies a lot on advanced tech, like imaging and robots. These tools help surgeons but also bring risks. Technical problems or software bugs can make surgeries harder and even cause harm.

Power and System Failures

Power and system failures in surgery can be very serious. They can mess up the procedure, leading to complications or needing to switch to open surgery. Having backup systems ready and being prepared for these issues is vital.

Sterilization and Cross-Contamination Issues

The equipment used in these surgeries must be sterilized well to avoid infections. Making sure all tools are clean and handled right is key to keeping patients safe. It’s important to have strict rules to avoid these problems.

In summary, while equipment issues are big worries in minimally invasive surgery, knowing these risks and taking steps to fix them can help. By facing these challenges and working to solve them, we can make these surgeries safer and more effective.

Increased Costs and Economic Considerations

Minimally invasive surgery has a complex financial side. It offers benefits like shorter recovery times and possibly lower healthcare costs. But, the cost of new technology and training is high.

Equipment and Training Expenses

Specialized equipment for these surgeries is pricey. This includes cameras, insufflators, and advanced tools. Keeping this equipment up-to-date also adds to the cost. Plus, doctors and staff need special training, which is expensive too.

Training programs for these surgeries are detailed and costly. They cover both theory and practical skills, often in simulation labs. The cost includes travel and accommodation for participants.

Insurance Coverage Challenges

Insurance coverage for these surgeries can be a problem. While many plans cover them, the level of coverage varies. Some insurers might not cover newer or experimental techniques fully. This can make planning and budgeting hard for patients and healthcare providers.

Pre-authorization processes can be slow and complicated. They might delay surgeries. Also, the payment rates for these surgeries can be different from traditional ones. This affects the financial health of hospitals.

Cost-Effectiveness Analysis

It’s important to analyze the costs and benefits of minimally invasive surgery. This means looking at recovery times, complication rates, and long-term health gains. It helps figure out if the higher upfront costs are worth it in the long run.

Research suggests that, despite higher initial costs, these surgeries can be cost-effective. They lead to shorter recovery times and fewer complications. But, these studies need to be updated regularly to reflect new technology and healthcare changes.

Conversion to Open Surgery: Causes and Consequences

Conversion to open surgery is a possible issue with minimally invasive procedures. Surgeons and patients need to know about it. Minimally invasive surgery has many benefits, but sometimes it must be changed to open surgery due to complications or technical problems.

It’s important to understand why and what happens when this conversion occurs. This knowledge helps set realistic expectations and plan for possible risks.

Emergency Conversion Scenarios

Emergency conversions to open surgery can happen for several reasons. These include:

  • Uncontrolled bleeding
  • Organ damage
  • Equipment failure
  • Inadequate visualization

Such situations require quick decisions and readiness from the surgical team. A study in the Journal of Surgical Research notes, “The ability to quickly convert to an open procedure is a critical skill for surgeons performing minimally invasive surgery.”

Psychological Impact on Patients

The need for a conversion to open surgery can affect patients’ minds. It’s key for healthcare providers to talk clearly with patients about this possibility and its effects.

“Patients should be informed about the possible risks and outcomes of converting to open surgery as part of the informed consent process.”

Surgical Planning for Possible Conversion

Good surgical planning is vital for managing risks of conversion to open surgery. This includes:

Planning Aspect

Description

Pre-operative assessment

Thorough evaluation of the patient’s condition to anticipate possible complications.

Intra-operative preparedness

Having the necessary equipment and personnel ready for a possible conversion.

Post-operative care

Ensuring proper care and monitoring after surgery, whether it was minimally invasive or converted to open surgery.

By preparing for the possibility of conversion, surgical teams can reduce risks and improve patient results.

Specific Complications of Minimally Invasive Techniques

Exploring minimally invasive surgery, we must note its specific complications. These methods have many benefits but also have limits. Knowing these helps us manage risks and improve patient care.

Access-Related Injuries

One major worry with minimally invasive surgery is access-related injuries. These can happen when inserting trocars or moving instruments. Vascular injuries are very serious and can cause a lot of bleeding. We need to plan and do the access carefully to avoid these risks.

Gas Insufflation Complications

Gas insufflation is key in laparoscopic surgery for clear views. But, it can cause gas embolism or subcutaneous emphysema. It’s important to watch and control the gas pressure to avoid these problems.

Thermal Injuries from Instruments

Using energy devices in surgery can lead to thermal injuries. These can happen from direct contact, capacitive coupling, or insulation failure. Surgeon awareness and the right technique are key to avoiding these injuries.

Unique Bleeding Challenges

Bleeding in minimally invasive surgery is tricky because of the limited view and hard direct pressure. We need to be skilled in controlling bleeding with special tools and methods. This ensures the situation is handled well.

In summary, while minimally invasive techniques have many benefits, they also come with specific complications. Understanding these issues helps us face challenges and improve patient outcomes.

Patient Selection Challenges

Choosing the right patients for minimally invasive surgery is complex. It requires looking at many factors. These include the patient’s body shape, past health issues, and current health.

Anatomical Contraindications

Some body shapes can make surgery harder or not possible. For example, those with lots of scar tissue from past surgeries or unusual body shapes might not be good candidates. We use imaging and other tests to check if a patient can have minimally invasive surgery.

A study in the Journal of Surgical Research says, “It’s key to check patients well before surgery to see who might face big risks.”

“Before surgery, we look at the patient’s health history, do a physical check, and use imaging to spot any body issues.”

Pre-existing Condition Considerations

Old health problems can raise the risks of surgery. Issues like heart disease, lung problems, or bleeding issues need special thought. We check the patient’s health and manage any problems to lower the chance of surgery complications.

Pre-existing Condition

Considerations for Minimally Invasive Surgery

Severe Heart Disease

Needs careful heart checks and watching during surgery.

COPD

May need changes in how we use anesthesia and breathing help.

Bleeding Disorders

Requires careful blood control and might change how we manage blood thinners.

Body Habitus Limitations

How a patient’s body is shaped can also be a problem. Being overweight can make it hard to see and work inside the body. We might need to find other ways or change how we do the surgery for these patients.

In summary, picking patients for minimally invasive surgery is a detailed process. We look at many things to make sure the surgery is safe and works well for the patient.

Limitations in Complex Surgical Cases

In complex surgeries, the limits of minimally invasive methods are clear. These techniques have changed many surgeries for the better. But, they face big challenges in complex cases.

Oncological Surgery Concerns

Oncological surgeries need to remove tumors carefully while saving healthy tissue. This is hard for minimally invasive methods. These surgeries need a lot of flexibility and feeling, which is hard to get with these techniques.

The small view and limited movement can make it hard to remove tumors fully. Also, doing precise lymph node dissections is tough with these methods alone.

Challenge

Description

Impact on Surgery

Restricted Field of Vision

Limited visibility of the surgical site

Potential for incomplete tumor removal

Limited Range of Motion

Constraints on instrument movement

Difficulty in achieving precise dissection

Lack of Tactile Feedback

Inability to feel tissues and structures

Risk of damaging surrounding healthy tissue

Challenges in Revision Surgeries

Revision surgeries face big challenges too. They involve going back to old surgical sites for more work. Scar tissue and changed anatomy make it hard to use minimally invasive methods.

Scar tissue and adhesions hide the normal anatomy. This makes it hard to use minimally invasive techniques. It can lead to more complications and might need an open surgery.

Emergency and Trauma Surgery Limitations

Emergency and trauma surgeries need fast action. They often have complex injuries that are hard to manage with minimally invasive methods. Quick access and control of bleeding are big challenges.

In emergencies, the limits of minimally invasive surgery are clear. It’s hard to see the full extent of injuries and control bleeding. Open surgery is often the best choice in these urgent cases.

Post-Operative Complications Specific to Minimally Invasive Surgery

Minimally invasive surgery is becoming more common. It’s important to know about its unique complications to improve patient care. These procedures have benefits like shorter recovery times and less damage to tissues. But, they also come with specific challenges for healthcare providers.

Port Site Hernias and Infections

Port site hernias and infections are big concerns with minimally invasive surgery. Port site hernias happen when the abdomen bulges through the surgical site. They can be serious and might need more surgery to fix.

  • Things that increase the risk of port site hernias include big port sizes, bad closure methods, and health issues like obesity or diabetes.
  • Port site infections can be mild or serious. They can affect the skin or go deeper into the body.

To avoid these problems, surgeons need to be careful during surgery. They also need to take good care of patients after surgery. Teaching patients to watch for early signs of trouble is also key.

Unique Pain Patterns

Minimally invasive surgery can cause unique pain patterns. These pains can be different from those after open surgery. They might include pain at the port sites or pain from the gas used during the surgery.

Dealing with these pains requires understanding their causes. It also needs the right pain management strategies.

Delayed Recognition of Complications

Another issue with minimally invasive surgery is delayed recognition of complications. Because these surgeries are less invasive, complications might not be obvious right away.

Doctors need to keep a close eye on patients after surgery. Even if everything seems fine at first, complications can develop later.

Cosmetic Outcomes and Expectations

Patients often expect good cosmetic results from minimally invasive surgery. These procedures usually leave smaller scars. But, how well these scars heal can vary.

Factor

Influence on Cosmetic Outcome

Surgical Technique

Precise closure and minimal tissue trauma improve cosmetic results.

Post-operative Care

Proper wound care and follow-up can minimize scarring.

Patient Factors

Genetic predispositions and skin type can affect scar appearance.

Talking to patients before surgery about these factors can help manage their expectations. This can lead to better satisfaction with their surgical experience.

Specialty-Specific Drawbacks of Minimally Invasive Surgery

Minimally invasive surgery has changed the medical field a lot. It helps patients recover faster and feel less pain after surgery. But, each surgical area has its own set of challenges.

Challenges in Orthopedic Applications

Orthopedic surgery deals with bones and joints. It faces special hurdles with minimally invasive methods. Getting precise and clear views of the area is hard.

A study showed that fixing complex fractures is tough. The lack of clear view and access can make surgery longer and riskier.

Challenge

Description

Potential Solution

Limited Visibility

Difficulty in visualizing the surgical site

Advanced imaging techniques

Instrumentation

Need for specialized instruments

Development of new surgical tools

Limitations in Cardiac Surgery

Cardiac surgery is very delicate. The main issue is keeping the heart stable and visible. This is hard to do without harming the heart.

“Minimally invasive cardiac surgery requires a high degree of precision and control, making it one of the more challenging applications of minimally invasive techniques.” – Medical Expert, Cardiac Surgeon

Neurosurgical Considerations

Neurosurgery is about the brain and spinal cord. It needs extreme care and precision. The brain’s complexity limits minimally invasive methods.

Gynecological and Urological Concerns

Gynecology and urology benefit from minimally invasive surgery. But, they face their own challenges. Laparoscopic gynecology deals with adhesions and variations. Urology struggles with the urinary tract’s delicate nature.

In conclusion, minimally invasive surgery has many benefits. But, each specialty has its own challenges. Knowing these helps us find better ways to improve results and reduce risks.

Comparison with Traditional Open Surgery

Minimally invasive surgery and traditional open surgery have their own pros and cons. Minimally invasive surgery is known for quick recovery and less pain. Yet, there are times when open surgery is better or even the best choice.

Situations Where Open Surgery May Be Superior

For complex surgeries like big cancer operations or tricky fixes, open surgery might be better. Open surgery gives the surgeon a wider view and direct access. This is key for precise and detailed work.

In heart surgery, open surgery is often chosen. It lets the surgeon work directly on the heart for more accurate work. For brain and spinal surgeries, the complexity often calls for an open approach for safety and precision.

Long-Term Outcome Differences

Looking at long-term results, several things matter. Minimally invasive surgery usually means less damage and faster healing. But, the patient’s health and the surgery type also play a big role.

Studies show that minimally invasive surgery can match or beat open surgery in the long run. But, it all depends on the surgeon, the patient, and the surgery method.

Hybrid Approaches as Solutions

Hybrid methods are becoming popular. They mix the best of both worlds. This way, surgeons get the quick recovery of minimally invasive surgery and the clear view of open surgery.

In some big abdominal surgeries, a hybrid method is used. It has a smaller cut than open surgery but offers direct access. This approach tries to find a balance between precision and the benefits of minimally invasive surgery.

Ethical and Informed Consent Issues

It’s important to make sure patients know all about the risks and benefits of minimally invasive surgery. Healthcare providers face big challenges as these procedures become more common. We must handle these challenges with care.

Marketing vs. Medical Reality

Marketing for minimally invasive surgery often talks up its benefits, like quick recovery and less scarring. But, we must also show the real risks and complications. Being open and honest with patients is vital.

A study in a top medical journal showed a gap between what’s promised and what really happens. This highlights the need for clear and balanced info.

“The ethical principle of informed consent requires that patients be provided with accurate and unbiased information about their treatment options.”

Patient Education Challenges

Teaching patients about minimally invasive surgery is tough. We need to make sure they know the good and the bad. This includes risks like equipment failure or surgeon mistakes.

Patient Education Topics

Description

Importance Level

Procedure Overview

General explanation of the surgery

High

Risks and Complications

Detailed discussion of possible risks

High

Alternative Options

Info on other treatment choices

Medium

Balancing Innovation with Proven Techniques

New minimally invasive techniques bring both chances and challenges. We need to keep improving care but also make sure new methods are safe. We must find a balance between new ideas and tested practices.

As we move forward in minimally invasive surgery, we must focus on ethics and patient education. This way, patients can make informed choices about their health.

Conclusion: Weighing the Risks and Benefits of Minimally Invasive Surgery

Minimally invasive surgery has many benefits, but it also has some drawbacks. It’s important to think about these carefully before making a decision.

We’ve looked at the technical challenges, the need for skilled surgeons, and the risks of equipment problems. Knowing these issues helps both doctors and patients make better choices.

It’s key to look at both sides of minimally invasive surgery. This way, we can make informed decisions that help patients get the best care. As medical technology improves, staying aware of the challenges is vital for top-notch patient care.

FAQ

What are the main technical limitations of minimally invasive surgery?

Minimally invasive surgery faces challenges like a limited view, restricted movement, and less touch feedback. These can make procedures more complex and longer.

How does surgeon experience affect the outcome of minimally invasive surgery?

A surgeon’s experience and skill greatly influence the success of minimally invasive surgery. More experienced surgeons often get better results because of their specialized training.

What are the possible risks of longer operation times in minimally invasive surgery?

Longer surgeries can mean more time under anesthesia and fatigue. This can affect patient safety and outcomes.

What equipment-related complications can occur during minimally invasive surgery?

Issues like tool malfunctions and technology failures can happen. These risks can be lowered by reliable equipment and strict cleaning protocols.

Are minimally invasive surgeries more expensive than traditional open surgeries?

Minimally invasive surgeries might cut down on recovery time and costs in the long run. But, the cost of new technology and training can be high upfront.

What are the challenges associated with patient selection for minimally invasive surgery?

Choosing the right patients is tough due to anatomical issues, existing health conditions, and body shape. Careful evaluation is key to avoid risks and improve results.

Can minimally invasive surgery be used for complex surgical cases?

Not all complex surgeries are suitable for minimally invasive methods. Cases like some cancer surgeries, revisions, or emergencies might face technical hurdles.

What are some post-operative complications specific to minimally invasive surgery?

Complications like hernias, infections, and unique pain can occur. It’s important to manage these to ensure a smooth recovery and patient satisfaction.

How does minimally invasive surgery compare to traditional open surgery in terms of outcomes?

Both methods have their pros and cons. The choice depends on the situation, patient needs, and the surgeon’s expertise.

What are the ethical considerations surrounding minimally invasive surgery?

Ethical issues include getting informed consent and balancing new techniques with proven methods. It’s also important to be honest about what to expect to keep patient trust.

What are the risks of conversion to open surgery during a minimally invasive procedure?

Switching to open surgery can happen due to problems or technical issues. Knowing the risks and being ready for this can help patients.

Are there any specialty-specific drawbacks to minimally invasive surgery?

Yes, different specialties face unique challenges. This includes areas like orthopedics, cardiology, neurosurgery, gynecology, and urology.


References

National Center for Biotechnology Information. Evidence-Based Medical Insight. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705225/

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