- 7/24 Live Call Center
Stem cells can develop into many cell types and act as the body’s repair system. They replace or restore damaged tissues, offering new possibilities for treating diseases.
Send us all your questions or requests, and our expert team will assist you.
preferred option for older patients (up to age 70-75) or those with comorbidities, which is common in myelofibrosis.
The Procedure: Stem cells are collected from the donor’s blood or marrow and infused into the patient. These cells are home to the marrow space. Over time, the healthy donor stem cells repopulate the marrow. Crucially, as the malignant clone is eliminated, the inflammatory signaling stops, and the body slowly degrades the collagen scar tissue, reversing the fibrosis.
For patients who are not transplant candidates, or as a “bridge” to transplant, JAK inhibitors are the cornerstone of treatment.
Pre-Transplant Optimization: JAK inhibitors are often used before a stem cell transplant to shrink the spleen and improve the patient’s physical condition (performance status), which enhances post-transplant outcomes.
Managing the consequences of marrow failure is a constant component of care.
Radiation Therapy: Low-dose radiation can be applied to the spleen to provide temporary relief from pain and bulk. It is also used to treat “extramedullary hematopoietic tumors”—masses of blood cells that form outside the marrow, such as near the spinal cord or lungs, causing compression.
The field is active with research into agents that target the disease beyond the JAK pathway.
Antifibrotic Agents: Research is ongoing into drugs that specifically target fibrosis-causing cells (fibroblasts) or the cytokines (such as TGF-beta) that drive scarring, aiming to “clean up” the marrow environment to allow healthy blood production.
Send us all your questions or requests, and our expert team will assist you.
Yes. Historically, age limits were strict, but with the advent of “Reduced Intensity Conditioning” (RIC) regimens, patients up to age 70, and even 75, can successfully undergo stem cell transplantation if they are physically fit and have good organ function. Biological age is more important than chronological age.
No, JAK inhibitors are not curative. They do not permanently eradicate the leukemia cells or the genetic mutation. Their primary role is to control symptoms, reduce spleen size, and improve quality of life. If the medication is stopped, symptoms and spleen enlargement typically return rapidly.
Splenectomy in myelofibrosis is risky. It carries a high rate of complications, including bleeding, blood clots (thrombosis) in the abdominal veins, and susceptibility to overwhelming infections. Furthermore, after the spleen is removed, the liver may enlarge rapidly to take over blood production (hepatomegaly).
Stopping JAK inhibitors abruptly can lead to a condition called “withdrawal syndrome.” This involves a rapid return of symptoms, sometimes worse than before, including high fever, respiratory distress, and shock-like symptoms. Any discontinuation or dose reduction must be tapered slowly under medical supervision.
No. Radiation is a local treatment. It is used to shrink a painful spleen or to treat a mass of blood cells pressing on a nerve or organ outside the marrow. It does not treat the widespread disease in the bone marrow or improve blood counts; in fact, it can temporarily lower blood counts further.
Knowing how long radioembolization lasts is key for those getting ready for it. The complexity of the procedure and the patient’s situation can affect the
Recovery after colon surgery is greatly affected by what we eat. At Liv Hospital, we focus on each patient, creating post-surgical diets that are safe
Nearly 200,000 people in the United States are diagnosed with an aortic aneurysm each year. This is a condition where the aorta, the main blood
Learn how long can you wait to have your gallbladder removed and what factors affect surgery timing. Deciding when to remove your gallbladder is a
Distinguishing between heartburn and a heart attack can be tough. Both can cause chest pain, making it hard to tell them apart. At Liv Hospital,
Your Comparison List (you must select at least 2 packages)
