Pulmonology focuses on diagnosing and treating lung and airway conditions such as asthma, COPD, and pneumonia, as well as overall respiratory health.

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Influenza: Symptoms and Risk Factors

The clinical presentation of influenza is characterized by an abrupt, often dramatic onset of symptoms. Unlike the common cold, which typically evolves gradually, influenza strikes suddenly, usually allowing patients to pinpoint the exact hour they fell ill. This rapid development of symptoms reflects the aggressive viral replication and the immediate, potent release of interferon and other inflammatory mediators. The spectrum of illness ranges from asymptomatic infection to fulminant respiratory failure. Recognizing the classic constellation of symptoms while remaining vigilant for atypical presentations is crucial for timely diagnosis and intervention. At Liv Hospital, clinical assessment focuses on identifying both the acute viral manifestations and the subtle signs of developing complications.

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Systemic Constitutional Symptoms

PULMONOLOGY

The hallmark of influenza is the prominence of systemic symptoms that affect the entire body, often overshadowing the respiratory complaints in the initial phase.

Fever and Chills

High fever is a cardinal sign of influenza, often spiking between 38 and 40 degrees Celsius. The fever typically lasts 3 to 4 days but can persist longer. It is frequently accompanied by severe chills and rigor, reflecting the body’s attempt to raise its core temperature to create an inhospitable environment for the virus. In elderly patients or those with immunosuppression, the fever response may be blunted or absent, necessitating a high index of suspicion based on other clinical signs.

Myalgia and Arthralgia

Severe muscle pain (myalgia) and joint pain (arthralgia) are characteristic of the flu. These pains are often most intense in the back, arms, and legs. The myalgia can be severe enough to make movement difficult and is sometimes accompanied by cutaneous hyperesthesia, where the skin feels sensitive to touch. This symptom is a direct result of the systemic release of cytokines such as interleukin-6 and tumor necrosis factor-alpha.

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Respiratory Tract Manifestations

PULMONOLOGY

While systemic symptoms dominate early on, respiratory symptoms become more prominent as the illness progresses and the virus damages the respiratory epithelium.

Non-Productive Cough

A dry, hacking cough is a frequent and often persistent symptom. It can be severe and may cause chest discomfort or burning. As the disease resolves, the cough may become productive if there is significant epithelial sloughing or secondary bacterial infection. The destruction of the tracheal cilia impairs the clearance of secretions, prolonging the cough reflex often for weeks after other symptoms have resolved.

Sore Throat and Rhinitis

Pharyngitis and nasal congestion are common but typically less severe than in the common cold. The sore throat may be severe in the first few days. Nasal obstruction and clear discharge (rhinorrhea) may occur, contributing to the overall sense of malaise. Inflammation of the upper airways can also cause substernal soreness and a sensation of rawness in the throat and trachea.

Pediatric Presentations

Influenza in children can present differently than in adults, often mimicking other pediatric illnesses.

  • Gastrointestinal Symptoms: Unlike adults, children with influenza frequently experience nausea, vomiting, and diarrhea. This can lead to dehydration, complicating the clinical picture.
  • Febrile Seizures: The rapid spike in temperature associated with influenza A can precipitate febrile seizures in susceptible young children.
  • Otitis Media: Inflammation of the Eustachian tube often leads to secondary ear infections, presenting as ear pain and fussiness.
  • Croup-like Symptoms: The virus can cause inflammation of the larynx and trachea, leading to a barking cough and stridor, particularly in infants.
PULMONOLOGY

Geriatric Presentations

In the elderly population, influenza presentation can be atypical and subtle, leading to delayed diagnosis and increased mortality.

  • Altered Mental Status: Confusion, lethargy, or a decline in functional status may be the only presenting signs in frail older adults.
  • Absence of Fever: A significant proportion of elderly patients may not mount a febrile response due to immunosenescence.
  • Exacerbation of Chronic Conditions: Influenza often presents as a worsening of underlying heart failure or chronic obstructive pulmonary disease rather than a primary respiratory infection.

Complications and Secondary Infections

The morbidity of influenza is primarily driven by its complications.

  • Bacterial Pneumonia: This is the most common serious complication. The viral damage to the respiratory lining creates a fertile environment for bacteria like Streptococcus pneumoniae and Staphylococcus aureus. Patients may improve initially and then suffer a relapse with higher fever and purulent sputum.
  • Primary Viral Pneumonia: This is a direct progression of the viral infection into the lung parenchyma. It is often severe, rapid in onset, and can lead to acute respiratory distress syndrome with high mortality.
  • Myositis and Rhabdomyolysis: Severe muscle inflammation can occur, leading to muscle breakdown and potential kidney damage.
  • Cardiac Complications: Myocarditis and pericarditis are rare but serious complications that can lead to arrhythmias and heart failure.

High-Risk Populations

Certain groups are statistically at a much higher risk of developing severe disease and complications.

  • Pregnancy: Physiological changes in the immune system, heart, and lungs during pregnancy make pregnant women more prone to severe illness, hospitalization, and death from influenza.
  • Chronic Medical Conditions: Individuals with asthma, diabetes, heart disease, kidney disease, and neurological disorders have less physiological reserve to handle the stress of the infection.
  • Immunosuppression: Patients undergoing chemotherapy, organ transplantation, or living with HIV/AIDS have compromised immune defenses, leading to prolonged viral shedding and severe disease.
  • Obesity: Morbid obesity has been identified as an independent risk factor for severe influenza complications.

Environmental and Behavioral Risk Factors

External factors influence transmission and severity.

  • Crowded Living Conditions: Nursing homes, dormitories, and military barracks facilitate rapid transmission.
  • Smoking: Smokers have damaged respiratory cilia and altered immune responses, making them more susceptible to infection and severe lower respiratory tract involvement.
  • Lack of Vaccination: The single most significant modifiable risk factor is the failure to receive the annual influenza vaccine.

Neurological Manifestations

Although primarily a respiratory virus, influenza can affect the nervous system.

  • Encephalopathy: Acute necrotizing encephalopathy is a rare but devastating complication seen primarily in children.
  • Guillain-Barre Syndrome: Influenza infection is a known trigger for this autoimmune disorder that attacks the peripheral nerves, leading to ascending paralysis.

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Assoc. Prof. MD. Engin Aynacı Assoc. Prof. MD. Engin Aynacı Pulmonology Overview and Definition
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FREQUENTLY ASKED QUESTIONS

What distinguishes flu symptoms from a cold?

Flu symptoms come on suddenly and include high fever, severe body aches, and fatigue, whereas cold symptoms come on gradually and primarily affect the nose and throat.

Muscle aches are caused by the immune system releasing inflammatory chemicals to fight the virus, which also causes inflammation in muscle tissues.

While rare in adults, children with influenza often experience vomiting and diarrhea, which can lead to dehydration requiring medical attention.

Aging weakens the immune system, making it harder to fight the virus, and older adults often have chronic conditions that the flu can severely exacerbate.

If a patient recovers from the flu but then suddenly develops a high fever, chest pain, and a productive cough, it often indicates bacterial pneumonia.

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