Pulmonology focuses on diagnosing and treating lung and airway conditions such as asthma, COPD, and pneumonia, as well as overall respiratory health.

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Diagnosis and Evaluation

The Diagnostic Imperative and Methodology

Diagnosing a lung abscess involves two main steps: first, confirming there is a cavity in the lung, and second, finding out what caused it and if there are any other problems. Lung abscesses are often mistaken for other conditions like empyema, tuberculosis, or cancer. At Liv Hospital, we use a fast, thorough approach with scans, lab tests, and sometimes procedures to make sure we get the right diagnosis, since treatment can be very different for each condition.

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Chest Radiography: The Screening Tool

PULMONOLOGY

A chest X-ray is the first test done for anyone with symptoms like cough, fever, or coughing up blood.

  • The Air Fluid Level: This is the pathognomonic sign of a lung abscess. It appears as a spherical cavity with a distinct, straight horizontal line separating the air above from the opaque liquid pus below. The walls of the cavity are usually thick and irregular in the acute phase, becoming thinner as the abscess heals.
  • Positional Clues: Aspiration abscesses favor specific segments due to bronchial anatomy: the posterior segment of the upper lobe and the superior segment of the lower lobe. An abscess found in the anterior lung fields is unusual for aspiration and suggests other causes such as septic emboli or cancer.
  • Differentiation from Empyema: On a standard X-ray, a parenchymal abscess must be distinguished from an empyema with a bronchopleural fistula, which is pleural. An abscess typically crosses lung fissures and is spherical, while an empyema is lenticular and conforms to the shape of the chest wall.
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Computed Tomography (CT) Scan: The Anatomical Gold Standard

PULMONOLOGY

A chest CT scan with contrast is almost always done at Liv Hospital to get a clearer diagnosis.

  • Precise Definition: The CT scan confirms the location of the lesion, distinguishing between parenchymal and pleural collections. It measures wall thickness and detects small satellite cavities or areas of necrosis that X-rays might miss.
  • Identifying Underlying Pathology: It is the best tool for detecting an underlying bronchial obstruction, such as a tumor, foreign body, or enlarged lymph nodes (lymphadenopathy) that may be compressing the airway.
  • Vascular Relations: Contrast CT highlights the relationship between the abscess and pulmonary vessels, identifying potential risks for massive hemoptysis, such as a Rasmussen’s aneurysm.
  • Guide for Intervention: It provides the roadmap for any potential drainage procedure, showing the safest path through the chest wall to avoid vital structures.

Microbiological Investigation: The Search for the Pathogen

Finding the exact germ causing the abscess is important for choosing the right antibiotics, but sputum samples are often mixed with normal mouth bacteria and can be misleading.

  • Sputum culture: Testing sputum can help find tuberculosis, fungi, or certain aggressive bacteria. But for primary abscesses, routine sputum cultures are not helpful for finding anaerobic bacteria, since these are already present in the mouth.
  • Putrid sputum: If the sputum smells very bad, it is a strong sign of anaerobic infection. In these cases, doctors usually do not need to do more invasive tests and can start treatment for anaerobic bacteria right away.
  • Blood cultures are only positive in a few cases, but they are important to check for infections that have spread through the blood, especially in patients with high fevers or chills.
PULMONOLOGY

Bronchoscopy: Indications and Utility

Bronchoscopy involves passing a flexible camera into the lungs to visualize the airways. It is not routine for every abscess, but it is mandatory in specific high risk scenarios.

  • Rule Out Cancer: In any patient with risk factors such as age over 45 or a history of smoking, or in those with atypical recovery, bronchoscopy is performed to visualize the airway and biopsy any obstructing mass or lesion.
  • Foreign Body Removal: If the CT scan suggests a foreign object is causing the obstruction, bronchoscopy is both therapeutic and diagnostic.
  • Protected Specimen Brush and BAL: Bronchoscopy allows collection of sterile culture samples from the lower airways using a protected specimen brush or bronchoalveolar lavage (BAL), avoiding mouth contamination. This is vital in immunocompromised patients or those failing empiric antibiotics.

Percutaneous Transthoracic Aspiration

For peripheral abscesses where bronchoscopy is non diagnostic, and the patient is deteriorating, a needle aspiration through the chest wall, performed under CT or ultrasound guidance, can obtain pus for definitive culture. This procedure carries a risk of pneumothorax or of pus entering the pleural space, leading to an empyema, so it is considered a second-line diagnostic tool reserved for complex cases.

Differential Diagnosis: The Masqueraders

The clinician must rigorously rule out other conditions that can mimic a lung abscess.

  • Cavitating Neoplasm: Squamous cell lung carcinoma frequently cavitates as the center of the tumor outgrows its blood supply and dies. The wall of a cancerous cavity is usually thick, nodular, and irregular.
  • Tuberculosis: Cavitary TB usually involves the lung apices and presents with similar constitutional symptoms like weight loss and night sweats. Sputum testing for TB is mandatory in endemic areas or high risk patients.
  • Wegener’s Granulomatosis: An autoimmune vasculitis that causes multiple cavitating nodules, often associated with kidney involvement and upper airway symptoms.
  • Pulmonary Embolism: A sterile pulmonary infarct, which is dead lung tissue resulting from a clot, can cavitate and sometimes become secondarily infected.
  • Infected Bulla or Cyst: A pre existing air cyst or bulla can fill with fluid during a bout of pneumonia, mimicking an abscess. Reviewing old X-rays helps distinguish this condition.

Laboratory Assessment

  • Complete Blood Count: Leukocytosis with a left shift, indicating immature neutrophils, tracks the acute inflammatory response. Anemia and thrombocytosis are common in chronic cases.
  • Inflammatory Markers: C reactive protein (CRP) and Procalcitonin are used to monitor the response to antibiotic therapy. A failure of CRP to fall suggests treatment failure or the development of complications.
  • Albumin: Levels are often low, reflecting the chronic inflammatory state and malnutrition associated with the disease.

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Assoc. Prof. MD. Engin Aynacı Assoc. Prof. MD. Engin Aynacı Pulmonology Overview and Definition
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FREQUENTLY ASKED QUESTIONS

Why do I need a CT scan if the X-ray showed the abscess?

The CT scan is necessary to measure the cavity precisely, ensure it is not a fluid collection outside the lung known as an empyema, and most importantly, to check for a tumor blocking the airway that caused the infection.

It is a safe procedure done under sedation. The main risks are minor bleeding or temporary low oxygen levels, but it provides crucial information about why the abscess formed, such as a hidden foreign body or cancer.

It can not be easy. Cancer cavities often have thicker, lumpier walls. We treat with antibiotics first and repeat imaging; if the abscess does not shrink, we biopsy it to rule out cancer.

Because the sputum has to pass through your mouth, it picks up all the mouth bacteria on the way out. This makes it hard to tell which bacteria came from the lung infection and which are just normal mouth flora.

It is a straight horizontal line seen on an X-ray. It implies a hollow space or cavity containing both liquid pus and air, a classic sign that the lung tissue has been destroyed and drained.

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