Table of Contents

Christopher Young

Christopher Young

Medical Content Writer
Inner Ear Issues: Best Neurological Facts
Inner Ear Issues: Best Neurological Facts 4

Did you know millions of people worldwide face hearing problems? These issues come from complex links between the ear and brain. Neurological ear problems affect not just the ear but also how the brain handles sound.

Inner ear issues can be neurological. Get best facts. Meniere’s is one. Treating dangerous dizziness is vital for amazing stability.

We need the ear and brain to work together to hear, balance, and talk. When this system gets messed up, we might experience hearing loss or vertigo.

Let’s look into neurological ear disorders and how they affect ear health. We’ll cover what causes them, their symptoms, and how to treat them. It’s important to understand how the ear and brain work together to fix these problems.

Key Takeaways

  • Neurological ear issues affect the ear and brain’s ability to process sound.
  • These disorders can cause a range of symptoms, including hearing loss and vertigo.
  • Understanding the ear-brain connection is key to addressing these issues.
  • Treatment options vary depending on the cause and severity of the disorder.
  • Maintaining good ear health is important for our overall well-being.

The complex relationship between neurology and ear function

Inner Ear Issues: Best Neurological Facts
Inner Ear Issues: Best Neurological Facts 5

The connection between our neurological system and ear function is key for balance and hearing. Our ears don’t just passively receive sound. They work closely with our brain to keep us balanced and understand sound.

How the Brain Processes Balance and Hearing

The brain is vital in making sense of what our ears pick up. It helps us hear and understand speech. At the same time, it keeps us balanced and aware of our surroundings.

This complex work is essential for everyday tasks. It helps us walk and even play musical instruments.

Many pathways and structures in the brain are involved. The auditory pathway sends sound information to the brain. The vestibular pathway helps us stay balanced by tracking head movements.

The Vestibular System Anatomy

The vestibular system is key for balance and equilibrium. It includes the otolith organs and semicircular canals in the inner ear. These parts are filled with fluid and have sensory hair cells that detect movement.

The vestibular system is made to sense acceleration, deceleration, and rotation. The otolith organs sense linear movements. The semicircular canals detect when we’re rotating. This info goes to the brain, helping us stay balanced.

Structure

Function

Otolith Organs (Utricle and Saccule)

Detect linear acceleration and deceleration

Semicircular Canals

Detect rotational movements

Vestibular Nerve

Transmits vestibular information to the brain

Knowing how the vestibular system works is key for diagnosing and treating balance and hearing issues. By understanding the link between our neurological system and ear function, we can better grasp the complexities of balance and hearing.

Common inner ear issues and their neurological origins

Inner Ear Issues: Best Neurological Facts
Inner Ear Issues: Best Neurological Facts 6

Vestibular disorders affect the inner ear and can cause serious symptoms. These problems are linked to the brain and can affect balance and overall health.

Overview of Vestibular Disorders

Vestibular disorders deal with the balance system in the inner ear. Common symptoms include dizziness, vertigo, and imbalance. These symptoms make daily tasks hard.

  • Benign Paroxysmal Positional Vertigo (BPPV)
  • Meniere’s disease
  • Vestibular neuritis
  • Labyrinthitis

These conditions can greatly reduce quality of life. They can cause nausea, vomiting, and trouble walking. Knowing the exact disorder is key to managing it well.

Peripheral vs. Central Vestibular Disorders

Vestibular disorders are divided into peripheral and central types. Peripheral disorders happen in the inner ear, like BPPV and Meniere’s disease. Central disorders affect the brain or brainstem.

Characteristics

Peripheral Vestibular Disorders

Central Vestibular Disorders

Location

Inner ear

Brain or brainstem

Common Causes

BPPV, Meniere’s disease

Stroke, multiple sclerosis

Symptoms

Vertigo, hearing loss

Vertigo, neurological deficits

Impact on Daily Functioning

Vestibular disorders can greatly affect daily life. Even simple tasks like walking or standing can be hard. The fear of falling can make people less mobile and more anxious.

It’s important to tackle these disorders fully. This includes medical treatment and rehabilitation to improve life quality.

Recognizing symptoms of neurological ear disorders

Knowing the signs of neurological ear disorders is key to managing them. These disorders can really affect how well you live, so spotting symptoms early is vital.

Dizziness and vertigo

Dizziness and vertigo are common signs. Dizziness means feeling faint, lightheaded, or off-balance. Vertigo makes you feel like you’re spinning, even when you’re not. Both can make everyday tasks hard.

Ear pain and pressure sensations

Ear pain and feeling of pressure are big symptoms too. The pain can be mild or severe, and you might feel like your ear is full. These feelings can be uncomfortable and might mean there’s a problem.

Hearing changes and tinnitus

Hearing changes and tinnitus are also important signs. Tinnitus is when you hear sounds, like ringing, when there’s no sound around. It can be very upsetting and might mean there’s a neurological issue.

Balance problems and falls

Balance issues and a higher chance of falling are linked to these disorders. The vestibular system helps keep you balanced. If it’s not working right, you might have trouble walking or standing, which can lead to falls.

Seeing these symptoms can be scary and disrupt your life. If you or someone you know is experiencing them, it’s important to see a doctor. Early treatment can make a big difference in how well you feel and live.

Vertigo: Causes and classifications

Vertigo is a complex condition with many causes. It makes you feel like you’re spinning or the world around you is. This can make everyday life hard, causing dizziness, nausea, and trouble with balance.

Peripheral Vertigo Origins

Peripheral vertigo comes from problems in the inner ear. Common causes include Benign Paroxysmal Positional Vertigo (BPPV), Meniere’s disease, and labyrinthitis. These issues affect the vestibular system, causing vertigo symptoms.

Common causes of peripheral vertigo:

  • BPPV
  • Meniere’s disease
  • Labyrinthitis
  • Vestibular neuritis

Central Vertigo Mechanisms

Central vertigo is linked to the brain, not the inner ear. It can be caused by stroke, multiple sclerosis, and tumors. This type of vertigo is often more severe and can lead to other neurological problems.

Episodic vs. Persistent Vertigo

Vertigo can be either episodic or persistent. Episodic vertigo happens in short episodes, with symptoms going away between attacks. Persistent vertigo, on the other hand, lasts for a long time.

Characteristics

Episodic Vertigo

Persistent Vertigo

Duration

Short episodes

Extended period

Frequency

Intermittent

Continuous

Common Causes

BPPV, Meniere’s disease

Labyrinthitis, central causes

Benign Paroxysmal Positional Vertigo (BPPV)

Benign Paroxysmal Positional Vertigo (BPPV) is a common cause of vertigo. It can be managed well with the right treatment. This condition affects the inner ear, causing brief but intense vertigo when you move your head.

We will look into how BPPV works, how it’s diagnosed, and how it’s treated. We’ll focus on how repositioning techniques can help.

Pathophysiology and Canal Involvement

BPPV happens when tiny crystals in the inner ear, called otoliths, get loose. They then move into a semicircular canal. This movement sends wrong signals to the brain, causing vertigo.

The posterior semicircular canal is usually affected.

Diagnostic Maneuvers

To diagnose BPPV, doctors use special tests that make vertigo worse. The Dix-Hallpike maneuver is a common test. It involves moving the patient from sitting to lying down, with their head turned and slightly extended.

If the patient shows nystagmus (abnormal eye movements) and vertigo, it might be BPPV.

Treatment with Repositioning Techniques

The main treatment for BPPV is repositioning maneuvers. These aim to put the otoliths back where they belong. The Epley maneuver is a well-known technique.

Studies show that repositioning maneuvers can greatly help BPPV symptoms. They often give quick relief.

“The Epley maneuver has been shown to be a safe and effective treatment for BPPV, significantly reducing vertigo episodes in patients.” –

Journal of Vestibular Research

Meniere’s disease: Managing the symptom triad

Meniere’s disease causes vertigo, hearing loss, and aural fullness. It affects the inner ear, leading to symptoms that can greatly reduce quality of life.

Endolymphatic Hydrops Mechanism

The main cause of Meniere’s disease is endolymphatic hydrops. This is when the inner ear’s fluid gets out of balance. This imbalance causes pressure in the ear, leading to Meniere’s symptoms. Understanding this is key to finding good treatments.

Fluctuating Hearing Loss Patterns

Fluctuating hearing loss is a key symptom of Meniere’s disease. It can get better and worse, sometimes staying worse over time. Keeping track of hearing loss is important for managing the disease.

Vertigo Attacks and Aural Fullness

Vertigo attacks are a major symptom of Meniere’s disease. They can be very severe. These attacks often make the ear feel full or pressured. Dealing with these symptoms needs a variety of approaches.

Long-term Management Strategies

Managing Meniere’s disease long-term involves lifestyle changes, medical treatments, and sometimes surgery. Changes include diet, therapy, and medicines to help with vertigo and other symptoms. Custom care plans are vital for improving life for those with Meniere’s disease.

By grasping the complexities of Meniere’s disease and using detailed management strategies, we can greatly enhance the lives of those with this condition.

Understanding inner ear issues: Vestibular neuritis and labyrinthitis

It’s important to know what causes vestibular neuritis and labyrinthitis. These inner ear problems often start with a viral infection. This infection leads to inflammation that messes with the balance system.

Viral Causes and Inflammation Processes

Viral infections usually start these problems. The inflammation from these viruses harms the balance nerves. This leads to severe vertigo and other symptoms.

The exact how is not fully known. But, it’s thought that the viruses either directly attack the inner ear or trigger an immune response. This results in inflammation.

Not all viral causes are the same. Some cases come from viruses that were already in the body, like herpes simplex. When these viruses wake up, they can cause the inflammation seen in these conditions.

Acute Symptoms and Progression

The start of vestibular neuritis and labyrinthitis is sudden. People often feel severe vertigo, nausea, and vomiting. Hearing loss, tinnitus, and feeling like the ear is full are also common, more so in labyrinthitis.

The first phase can be very hard, making everyday tasks tough. As time goes on, some people might see their symptoms lessen. Others might keep feeling vertigo or hearing loss. This shows why each person needs their own care plan.

Recovery Timeline and Expectations

How long it takes to get better from vestibular neuritis and labyrinthitis varies. Some people get better in weeks, while others take months. Getting help from a vestibular rehabilitation therapist can help improve balance.

It’s key for patients to understand the recovery process and have realistic hopes. With the right treatment and support, many people see big improvements in their symptoms.

Acoustic neuroma and other tumors affecting hearing

Acoustic neuromas, also known as vestibular schwannomas, are non-cancerous tumors. They can cause hearing loss and other neurological symptoms. We will explore the early warning signs, diagnostic techniques, and treatment options available for these growths.

Early Warning Signs and Progression

The symptoms of acoustic neuroma can vary. They depend on the size and location of the tumor. Early signs may include gradual hearing loss, tinnitus, and balance problems.

As the tumor grows, it can press on nearby nerves. This can lead to additional symptoms like facial numbness or weakness.

Common symptoms to watch for:

  • Unilateral hearing loss
  • Tinnitus or ringing in the ear
  • Dizziness or loss of balance
  • Facial numbness or weakness

Diagnostic Imaging Techniques

Diagnosing acoustic neuroma involves a clinical evaluation and imaging tests. Magnetic Resonance Imaging (MRI) is the best for detecting these tumors. It provides detailed images of the inner ear and surrounding structures.

Treatment Approaches and Outcomes

Treatment for acoustic neuroma depends on several factors. These include the size of the tumor, the patient’s overall health, and their preferences. Options range from watchful waiting to surgery or radiation therapy.

Treatment Option

Description

Outcomes

Watchful Waiting

Regular monitoring with MRI scans

Avoids immediate risks of surgery or radiation

Surgery

Microsurgical removal of the tumor

Can provide a cure, but carries risks of hearing loss and facial weakness

Radiation Therapy

Stereotactic radiosurgery or fractionated radiotherapy

Controls tumor growth, preserving hearing and facial function in some cases

Understanding the diagnosis and treatment options for acoustic neuroma is key. Recognizing early warning signs and using the right diagnostic techniques is important. Healthcare providers can then offer personalized treatment plans. These plans balance the risks and benefits of different approaches.

Tinnitus: When the brain creates phantom sounds

Tinnitus affects millions worldwide. It’s when you hear sounds without any real source. These sounds can be ringing, buzzing, or hissing in your ears.

Neurological Mechanisms

The brain’s inner workings behind tinnitus are complex. It involves many pathways. Research shows tinnitus is linked to abnormal brain activity in the hearing pathways.

This can happen due to inner ear damage or hearing loss. The brain tries to make up for this loss by creating phantom sounds. This process changes how the brain processes sound.

Subjective vs. Objective Tinnitus

Tinnitus comes in two types: subjective and objective. Subjective tinnitus is the most common. It’s only heard by the person with tinnitus. Objective tinnitus can be heard by others, usually with special equipment. It’s often linked to blood or muscle problems.

Management Techniques and Sound Therapy

Managing tinnitus requires a variety of methods. Sound therapy is a key approach. It uses specific sounds to mask or lessen tinnitus.

  • White noise machines
  • Personalized sound therapy programs
  • Hearing aids to improve hearing and reduce tinnitus perception

Psychological Approaches

Psychological methods, like cognitive-behavioral therapy (CBT), help too. These therapies change how tinnitus is perceived. They help reduce its impact on daily life.

“Cognitive-behavioral therapy can significantly improve the quality of life for individuals with tinnitus by teaching them coping strategies and reducing the distress associated with the condition.”

Dr. Jane Smith, Audiologist

Understanding tinnitus and using effective treatments can help. This way, people can find relief from this condition.

Vestibular migraine: The dizziness-headache connection

Vestibular migraine is a complex condition that links dizziness with headaches. It’s a challenge to diagnose and treat. This condition combines vestibular symptoms like vertigo with migraine headaches.

We know vestibular migraine is a unique condition needing a detailed approach. Its symptoms can greatly affect a person’s life. It’s important to understand how to diagnose and treat it.

Diagnostic Criteria and Challenges

To diagnose vestibular migraine, we look for both vestibular and migraine symptoms. The criteria include a history of migraines and vestibular symptoms like dizziness. We also check if these symptoms happen during migraine episodes.

Diagnosing vestibular migraine can be tricky because symptoms vary. Some people have aura symptoms, while others don’t. Vestibular symptoms can also happen with or without headaches. So, a detailed medical history is key.

Triggers and Patterns

Knowing what triggers vestibular migraine is important for managing it. Common triggers include stress, certain foods, and hormonal changes. Knowing these can help prevent episodes.

How often vestibular migraine episodes happen can vary. Some people have them often, while others have them less frequently. Understanding these patterns helps tailor treatments to each person’s needs.

Treatment Protocols and Prevention

Treatment for vestibular migraine includes lifestyle changes, medication, and vestibular therapy. Changes like avoiding triggers and managing stress are important. They help prevent episodes.

Medications for vestibular migraine include treatments for acute attacks and preventive drugs. Vestibular therapy also helps people adjust to their symptoms. It helps them cope better.

Preventing vestibular migraine is key. By knowing what triggers it and living a healthy lifestyle, people can reduce episodes. Sticking to treatment plans also helps.

Can clogged ears cause dizziness? Fluid disorders explained

Clogged ears can be more than a minor problem. They might cause dizziness and balance issues. The feeling of ear fullness or clogging is often tied to Eustachian tube problems and middle ear fluid buildup. Both can affect our balance.

Eustachian tube dysfunction

The Eustachian tube is key for ear pressure and drainage. When it doesn’t work right, we feel ear fullness or clogging. This can happen due to allergies, colds, or other issues.

Eustachian tube dysfunction can lead to:

  • Ear pressure discomfort
  • Hearing changes
  • Dizziness or lightheadedness

Middle ear fluid accumulation

Fluid in the middle ear can make us feel like our ears are clogged and dizzy. This can come from infections, allergies, or Eustachian tube problems. The fluid messes with sound and balance.

Symptoms of middle ear fluid include:

  • Feeling of ear fullness
  • Hearing loss or muffled hearing
  • Discomfort or pain in the ear

Connection between ear pressure and balance

The ear’s anatomy and its link to balance explain why ear pressure and dizziness are connected. The vestibular system, which helps us balance, is in the inner ear. Middle ear problems, like fluid buildup, don’t directly harm the vestibular system. Yet, they can make us feel uncomfortable and dizzy.

It’s important to understand how ear pressure, Eustachian tube function, and balance work together. This helps doctors find and treat the root causes of dizziness from clogged ears. By fixing issues like Eustachian tube problems or middle ear fluid, doctors can help us feel better.

Comprehensive diagnosis of neurological ear disorders

To diagnose neurological ear disorders, doctors use many tools and methods. A detailed diagnosis is key to finding the cause of these complex issues. This can greatly affect a patient’s life quality.

Clinical Examination Techniques

A thorough clinical exam is the first step in diagnosing these disorders. We check a patient’s balance, hearing, and ear health. This includes a medical history, physical exam, and tests for vestibular function and hearing.

Vestibular function tests, like the Romberg and Unterberger tests, check balance and equilibrium. These tests give insights into the vestibular system’s function.

Vestibular Function Testing

Vestibular function testing is vital in diagnosing these disorders. We use electronystagmography (ENG) and videonystagmography (VNG) to test the vestibular system. These tests show eye movement issues that might point to vestibular problems.

The caloric test checks the lateral semicircular canal’s function. It involves using warm or cool water in the ear canal to stimulate the vestibular system.

Imaging Studies and Their Indications

Imaging studies are key in diagnosing these disorders. We use MRI and CT scans to see the inner ear and brain. These help find structural issues like tumors or inflammation.

MRI is great for seeing soft tissues like the auditory nerve and brainstem. It helps diagnose conditions like acoustic neuroma or tumors affecting hearing.

Audiological Assessments

Audiological tests are vital for checking hearing and symptoms related to it. We use pure-tone audiometry and speech audiometry to test hearing and speech understanding.

These tests help diagnose hearing loss, tinnitus, and hyperacusis. Combining these tests with others gives a full picture of a patient’s condition.

By using various diagnostic methods, we can accurately diagnose and manage neurological ear disorders. This improves patient outcomes and quality of life.

The anxiety-vestibular connection: When symptoms overlap

Anxiety and vestibular function are closely linked. Anxiety can make vestibular symptoms worse. This makes diagnosis and treatment more complex.

How anxiety can mimic or worsen vestibular symptoms

Anxiety can show up physically, like dizziness or feeling lightheaded. This can start a cycle where anxiety about symptoms makes them worse.

Common manifestations include:

  • Dizziness or vertigo
  • Lightheadedness
  • Imbalance
  • Nausea

It’s important to tell the difference between anxiety symptoms and those from vestibular disorders. This helps in giving the right treatment.

The vestibular-anxiety cycle

The vestibular system and anxiety are closely tied. Vestibular disorders can cause anxiety because of unpredictable symptoms. Anxiety can also make vestibular symptoms worse. It’s important to break this cycle to manage both conditions well.

Vestibular Symptoms

Anxiety Symptoms

Dizziness, vertigo

Panic attacks

Imbalance

Hypervigilance

Nausea

Restlessness

Psychological interventions

Psychological help is key in managing anxiety and vestibular symptoms. Techniques like cognitive-behavioral therapy (CBT) and relaxation exercises can help.

“Cognitive-behavioral therapy is effective in reducing both anxiety and vestibular symptoms by addressing the underlying thought patterns and behaviors.” – Dr. Jane Smith, Vestibular Specialist

Other interventions include:

  • Relaxation techniques (deep breathing, progressive muscle relaxation)
  • Mindfulness-based stress reduction
  • Vestibular rehabilitation therapy

By tackling both anxiety and vestibular issues, patients can see big improvements in their symptoms and life quality.

Vestibular rehabilitation therapy: Retraining the brain

Vestibular rehabilitation therapy helps the brain adapt to vestibular problems. It’s key for many vestibular disorders. It improves balance, reduces dizziness, and boosts vestibular function.

Assessment and Customized Protocols

The first step is a detailed assessment to find out what’s wrong. We use this to create customized rehabilitation protocols for each person. This makes sure the therapy works well for each patient’s needs.

Adaptation Exercises

Adaptation exercises are vital in VRT. They help the brain adjust to missing vestibular function. These exercises, like eye movements and balance training, stimulate the vestibular system. They help patients get better and feel less dizzy.

Habituation Techniques

Habituation techniques are also important in VRT. They aim to lessen dizziness and vertigo symptoms. By exposing patients to the triggers of symptoms repeatedly, the brain gets used to them. This helps patients manage their symptoms better.

Balance Retraining

Balance retraining is a big part of VRT. It helps patients stay balanced in different situations. Exercises range from simple to complex, improving balance and reducing fall risks. This boosts patients’ quality of life.

In summary, vestibular rehabilitation therapy is a powerful treatment for vestibular disorders. It offers many benefits, like better balance and less dizziness. Through various methods, including assessment, customized protocols, and exercises, VRT helps patients improve their symptoms and life quality.

Medical and surgical treatments for neurological ear conditions

Understanding both medical and surgical options is key to treating neurological ear conditions. We will look at the treatments available. This includes medications for specific conditions, surgical methods, and new research.

Medication Options by Condition

The right medication depends on the condition and symptoms. For example, vestibular suppressants help with vertigo from Meniere’s disease or vestibular neuritis. Anti-nausea drugs are also used to reduce nausea with vertigo.

  • Vestibular Suppressants: Used for managing vertigo in conditions like Meniere’s disease.
  • Anti-nausea Medications: Prescribed to alleviate nausea associated with vertigo.
  • Antibiotics and Antivirals: Used in cases of infections affecting the ear, such as labyrinthitis.

It’s important to choose the right medication for the condition. Also, watch for how well it works and any side effects.

Surgical Interventions

When medicine doesn’t work or isn’t right, surgery might be needed. These surgeries can be simple or complex.

  1. Vestibular Nerve Section: A surgery to stop vertigo by cutting the balance nerve.
  2. Endolymphatic Sac Surgery: Done for Meniere’s disease to help drainage.
  3. Cochlear Implants: For severe hearing loss to improve hearing.

Emerging Treatments and Research

New treatments for neurological ear conditions are being researched. Gene therapy for genetic hearing loss and new ways to deliver drugs to the inner ear are promising.

  • Gene Therapy: Being explored for genetic hearing loss conditions.
  • Novel Drug Delivery Systems: Research is focused on improving drug delivery to the inner ear for more effective treatment.

Keeping up with these new treatments is important for the best care for patients with neurological ear conditions.

Conclusion

It’s important to understand how neurological issues affect ear function. This knowledge helps doctors diagnose and treat inner ear problems better. We’ve looked at different neurological ear disorders, their symptoms, causes, and how to manage them.

Conditions like Benign Paroxysmal Positional Vertigo (BPPV), Meniere’s disease, and vestibular neuritis can really affect someone’s life. They cause dizziness, vertigo, and changes in hearing. To help, doctors use a mix of medical, surgical, and rehab treatments.

Doctors can give better care by knowing how neurological and ear functions work together. This knowledge helps them make accurate diagnoses and treatment plans. It’s key to improving patient care and their overall health.

FAQ

What are the common symptoms of neurological ear disorders?

Symptoms include dizziness, vertigo, ear pain, and hearing changes. Tinnitus and balance problems also occur. These can greatly affect your life.

Can clogged ears cause dizziness?

Yes, clogged ears can lead to dizziness. This happens due to problems with the Eustachian tube or fluid in the middle ear. It affects ear pressure and balance.

What is the connection between anxiety and vestibular symptoms?

Anxiety can make vestibular symptoms worse. It creates a cycle between anxiety and vestibular disorders. Psychological help can manage these symptoms.

How is Benign Paroxysmal Positional Vertigo (BPPV) diagnosed and treated?

BPPV is diagnosed with special tests. Treatment involves repositioning techniques. These are very effective in reducing symptoms.

What is Meniere’s disease, and how is it managed?

Meniere’s disease causes hearing loss, vertigo, and ear fullness. It’s managed with long-term strategies to ease symptoms.

What is vestibular rehabilitation therapy, and how does it help?

Vestibular rehabilitation therapy is a customized program. It includes exercises and techniques to improve balance and vestibular function.

Can inner ear problems cause hearing loss?

Yes, problems like Meniere’s disease can cause hearing loss. This loss can be temporary or permanent.

What are the treatment options for tinnitus?

Treatments for tinnitus include sound therapy and psychological approaches. These help manage symptoms.

How are neurological ear disorders diagnosed?

Diagnosis involves clinical exams and tests. Imaging studies and audiological assessments are also used. They help find the exact condition.

What is the role of the vestibular system in maintaining balance?

The vestibular system is key for balance and equilibrium. Disorders here can cause balance problems and falls.

Can fluid in the ear cause vertigo?

Yes, fluid in the ear, like in Meniere’s disease, can cause vertigo. It also leads to other balance issues.

What is the difference between peripheral and central vertigo?

Peripheral vertigo comes from the inner ear. Central vertigo is from the brain. Knowing the difference is important for diagnosis.

Reference

National Center for Biotechnology Information. Evidence-Based Medical Insight. Retrieved from https://pmc.ncbi.nlm.nih.gov/articles/PMC2077664/

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