Discover the treatment options in Translational Neurology at Liv Hospital. From Stem Cells & Translational Neurology to rehabilitation, find your path to recovery.
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Treatment and Rehabilitation
The pinnacle of translational neurology is the development of gene therapies. For monogenic diseases (caused by a single gene error), scientists can now deliver a functional copy of the gene using viral vectors. This has transformed lethal conditions like Spinal Muscular Atrophy into manageable ones.
Antisense Oligonucleotides (ASOs) are synthetic strands of DNA/RNA that bind to the patient’s genetic material to modify how protein is made. These “designer drugs” can silence a toxic gene or force the body to skip over a mutation. This technology is customizable, allowing for rapid development for rare mutations.
Translational research is exploring the potential of stem cells not just to replace lost neurons, but to protect existing ones. Induced Pluripotent Stem Cells (iPSCs) allow researchers to take a patient’s skin cell, turn it into a neuron in a dish, and test drugs on it. This creates a personalized model of the patient’s brain for testing.
While replacing complex brain circuits is challenging, stem cells are showing promise in simpler applications, such as replacing the dopamine producing cells lost in Parkinson’s disease or the insulating cells in Multiple Sclerosis. The goal is true biological repair of the nervous system.
Bio-electronic medicine treats the nervous system with electricity rather than drugs. Deep Brain Stimulation (DBS) is a well established example, but translational research is making it “smart.” Closed loop DBS systems can sense abnormal brain activity and deliver stimulation only when needed, adapting in real time to the patient’s state.
Optogenetics is a cutting edge research tool being translated toward potential human use. It involves genetically modifying neurons to respond to light. This allows for the precise activation or silencing of specific neural circuits with millisecond timing, offering a level of control impossible with drugs or electricity.
Developing a new drug takes decades. Translational neurology accelerates this by using artificial intelligence to screen existing drugs for new uses. By analyzing the molecular structure of thousands of approved medications, AI can predict which ones might dock onto a neurological target.
This “in silico” (computer based) biology allows researchers to simulate how a drug will interact with the brain before ever touching a petri dish. It narrows down the candidates to the most promising few, drastically reducing the time and cost of moving to human trials.
The traditional clinical trial is rigid and slow. Translational neurology utilizes “adaptive trial designs.” These trials allow researchers to change the parameters while the study is ongoing based on the data being collected. If a drug is clearly failing, that arm can be dropped. If a specific subgroup is responding well, enrollment can focus on them.
Platform trials allow multiple different drugs to be tested against a single placebo group simultaneously. This is highly efficient, saving time and reducing the number of patients who receive a placebo. It creates a perpetual infrastructure for testing therapies.
Liv Hospital Ulus
Prof. MD. Nebil Yıldız
Neurology
Liv Hospital Ulus
Prof. MD. Nimet Dörtcan
Neurology
Liv Hospital Ulus
Prof. MD. Selda Korkmaz Yakar
Neurology
Liv Hospital Vadistanbul
Prof. MD. Ayhan Öztürk
Neurology
Liv Hospital Vadistanbul
Spec. MD. Hatice Çil
Neurology
Liv Hospital Bahçeşehir
Asst. Prof. MD. Yavuz Bekmezci
Neurology
Liv Hospital Bahçeşehir
MD. Hatice Yelda Yıldız
Neurology
Liv Hospital Bahçeşehir
Prof. MD. Belma Doğan Güngen
Neurology
Liv Hospital Bahçeşehir
Spec. MD. Merve Hilal Dolu
Pediatric Neurology
Liv Hospital Bahçeşehir
Spec. MD. Sevıl Yusıflı
Neurology
Liv Hospital Bahçeşehir
Spec. MD. Yasemin Giray
Neurology
Liv Hospital Topkapı
Assoc. Prof. MD. Figen Yavlal
Neurology
Liv Hospital Topkapı
Spec. MD. Güneş Altıokka Uzun
Neurology
Liv Hospital Ankara
Assoc. Prof. MD. Hatice Balaban
Neurology
Liv Hospital Ankara
Asst. Prof. MD. Özlem Aksoy Özmenek
Neurology
Liv Hospital Ankara
Spec. MD. Filiz Ökten Özyüncü
Neurology
Liv Hospital Gaziantep
Spec. MD. EFTAL GÜRSES SEVİNÇ
Neurology
Liv Hospital Samsun
Prof. MD. Ömer Faruk Aydın
Pediatric Neurology
Liv Hospital Samsun
Spec. MD. Hikmet Dolu
Neurology
Liv Bona Dea Hospital Bakü
MD. AZER QULUZADE
Neurology
Liv Bona Dea Hospital Bakü
Spec. MD. STEVAN TEKIC
Neurology
MD. Dr. Azer Kuluzade
Neurology
Psyc. Selin Ergeçer
Stroke Center
Liv Hospital Ulus + Liv Hospital Vadistanbul
Prof. MD. Gülşen Köse
Pediatric Neurology
Liv Hospital Vadistanbul + Liv Hospital Bahçeşehir
Prof. MD. Yakup Krespi
Neurology
Send us all your questions or requests, and our expert team will assist you.
An ASO (Antisense Oligonucleotide) is a small piece of synthetic DNA or RNA that binds to your genetic material to block the production of a bad protein or fix a genetic error.
Smart DBS devices listen to your brain waves and only deliver an electrical pulse when they detect the specific pattern of a symptom (like a tremor), saving battery and reducing side effects.
These are stem cells made by taking a regular adult cell (like skin) and reprogramming it back into an embryonic like state, allowing it to become any type of cell, including a brain cell.
Old drugs are already proven to be safe in humans, so if we find they work for a brain disease, we can get them to patients much faster than inventing a brand new molecule.
A platform trial is a study designed to test multiple different treatments at the same time using a single master protocol, which is faster and more efficient than running separate studies.
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