Translational Neurology Diagnosis and Imaging

Translational neurology has ushered in the era of “theranostics,” a portmanteau of therapeutics and diagnostics. This approach involves developing a diagnostic test that identifies a specific molecular target, which is then paired with a therapy designed to hit that same target. It ensures that treatments are only given to patients who biologicaly express the disease mechanism.

• Coupling of diagnostic tests with therapies
• Identification of molecular targets
• Patient selection for specific drugs
• Monitoring of target engagement
• Minimization of ineffective treatment trials

This precision prevents the “trial and error” approach to prescribing. Instead of guessing if a drug will work, clinicians can use a theranostic agent to visualize the disease burden and predict the response. This is particularly prevalent in neuro-oncology and increasingly in neurodegenerative disorders.

• Precision dosing based on disease burden
• Visual confirmation of drug delivery
• Reduction of treatment toxicity
• Improvement of cost effectiveness
• Streamlining of clinical decision making