Cardiology
Assoc. Prof. MD.Sinem Özbay Özyılmaz
Cardiology
Areas Of Interests
Structural heart diseases
Heart valve diseases
Congenital heart diseases
MitraClip / TriClip procedures
Advanced cardiac imaging
Left atrial appendage closure
Cardiac magnetic resonance imaging (Cardiac MRI)
Coronary artery diseases and interventions
Stenting
IVUS (Intravascular Ultrasound)
Hypertension
Leading Cardiologist Delivering Advanced, Patient-Focused, and Evidence-Based Heart Care
Assoc. Prof. Dr. Sinem Özbay Özyılmaz is a distinguished cardiologist at İstinye University Hospital, renowned for her patient-centric approach and expertise in advanced cardiovascular care. Graduating from Uludağ University Faculty of Medicine, she completed her specialty training in cardiology at the same institution, laying a strong foundation for a career dedicated to precise diagnostics, innovative treatments, and holistic patient care. Throughout her professional journey, Dr. Özbay Özyılmaz has contributed to leading cardiology departments, including Istanbul University of Health Sciences, Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, Biruni University Faculty of Medicine, and Medikal Park Florya Hospital, where she combined rigorous clinical practice with academic engagement. Her approach emphasizes world-class care through minimally invasive procedures, advanced imaging, and evidence-based treatment protocols, ensuring optimal outcomes, faster recovery, and enhanced patient comfort.
Dr. Özbay Özyılmaz’s clinical expertise encompasses structural heart diseases, heart valve disorders, congenital heart conditions, coronary artery disease, and hypertension management. She is highly skilled in performing MitraClip and TriClip procedures, left atrial appendage closure, intravascular ultrasound, coronary stenting, and advanced cardiac imaging, including cardiac magnetic resonance imaging. Her precision in diagnostics, combined with a focus on minimally invasive interventions, enables patients to receive treatment that balances efficacy, safety, and recovery time. She is deeply committed to tailoring care to individual patient needs, guiding them through complex decisions with empathy, clarity, and professionalism.
Beyond her clinical practice, Dr. Özbay Özyılmaz is an academic authority and an active researcher in cardiology. She has contributed to numerous scientific publications, congress presentations, and research projects, strengthening evidence-based approaches to cardiovascular medicine. Her mentorship and teaching at multiple universities underscore her dedication to cultivating the next generation of cardiologists while advancing clinical standards. She continuously integrates the latest technological advancements and internationally recognized protocols into her practice, reflecting her commitment to excellence and innovation in cardiology.
Assoc. Prof. Dr. Sinem Özbay Özyılmaz exemplifies the synthesis of clinical mastery and scientific leadership, delivering comprehensive, compassionate, and state-of-the-art cardiovascular care. Patients at İstinye University Hospital benefit not only from her advanced procedural expertise but also from her unwavering dedication to individualized treatment, comfort, and long-term heart health, making her a trusted leader in the field of modern cardiology.
A) Articles Published in Internationally Refereed Journals:
- Özyılmaz S, Alış E.E, Ermis E, Allahverdiyev S. Ucar H. Assessment of the Relationship between Mortality and Troponin I Levels in Hospitalised Patients with the Novel Coronavirus (COVID-19) Medicina (Kaunas) 20 Dec 13;56(12):693.,doi: 10.3390/medicina56120693.
- Özyılmaz S, Püşüroğlu H. Assessment of the relationship between the ambulatory electrocardiography-based micro T-wave alternans and the predicted risk score of sudden cardiac death at five years in patients with hypertrophic cardiomyopathy.
Anatol J Cardiol. 2018 Sep;20(3):165-173. doi: 10.14744/AnatolJCardiol. 2018.15945. - Ozyilmaz S, Akgul O, Uyarel H, Pusuroglu H, Karayakalı M, Gul M, Cetin M, Satilmisoglu H, Yildirim A, Bakir I. Assessment of the Association Between the Presence of Fragmented QRS and the Predicted Risk Score of Sudden Cardiac Death at Five Years in Patients with Hypertrophic Cardiomyopathy. Anatol J Cardiol. 2017;18:54-61. Â Doi: 10.14744/AnatolJCardiol.2017.7593.
- Ozyilmaz S, Akgul O, Uyarel H, Pusuroglu H, Gul M, Satilmisoglu MH, Bolat I, Ozyilmaz I, Uçar H, Yildirim A, Bakir I. The importance of the neutrophil-to-lymphocyte ratio in patients with hypertrophic cardiomyopathy. Rev Port Cardiol. 2017; 36:239-246. doi: 10.1016/j.repc.2016.09.014.
- Ozyilmaz S, Alişir MF, Serdar OA, Uzaslan E. The value of the coronary artery calcium score in the early diagnosis of coronary artery disease in patients with stable chronic obstructive pulmonary disease. Anatol J Cardiol 2015; 25:592-597, DOI:10.5152/AnatolJCardiol. 2015.6020.
- Ozyilmaz S, Satilmisoglu MH, Gül M, Uyarel H, Serdar OA. Evaluation of the Association Between Serum Uric Acid Level and the Predicted Risk Score of Sudden Cardiac Death in Five Years in Patients with Hypertrophic Cardiomyopathy. Archives of the Turkish Society of Cardiology 2018; 46(2), 111-120., Doi: 10.5543/tkda.2017.60094.
- Satilmisoglu MH, Ozbay Ozyilmaz S, Gul M, Ak Yildirim H, Kayapinar O, Gokturk K, Aksu H, Erkanli K, Eksik A. Predictive values of D-dimer assay, GRACE scores and TIMI scores for adverse outcome in patients with non-ST-segment elevation myocardial infarction. Ther Clin Risk Manag. 2017; 13:393"“400.
- Doi: 10.2147/TCRM.S124794.
- Emrah Ermis, Sinem Ozbay Ozyilmaz, Emre Salabas, Cem Senol, Mahir Cengiz, Samir Allahverdiyev, Hakan Ucar. The relationship between erectile dysfunction and the Atherogenic Index of Plasma. IJIR: Your Sexual Medicine Journal https://doi.org/10.1038/s41443-019-0167-2.
- Ozyilmaz I, Ozyilmaz S, Tola HT, Saygi M, Kiplapinar N, Tanidir N, Ergul Y, Guzeltas A, Odemis E. Holter electrocardiography findings and P-wave dispersion in pediatric patients with transcatheter closure of atrial septal defects. Annals of Noninvasive Electrocardiology. 2014; 19:174-81. DOI: 10.1111/anec.12104.
- Öztürk D, Erturk M, Celık O, Ozyılmaz S, Akturk F, Cakmak HA, Aksu H, Pusuroglu H, Yalçın AA, Uslu N.   The role of the neutrophil/lymphocyte ratio in patients with rheumatic mitral stenosis as an indicator of spontaneous echocardiographic contrast. Kardiol Pol. 2014; 72:969-976. DOI: 10.5603/KP. a2014.0093.
- Ertürk M, Öner E, Kalkan AK, Püşüroğlu H, Özyılmaz S, Akgül Ö, Ünal Aksu H, Aktürk İF, Çelik Ö, Uslu N. The role of isovolumic acceleration in predicting subclinical right and left ventricular systolic dysfunction in patients with metabolic syndrome. Anadolu Kardiyol Derg. 2015; 15:42-49. doi: 10.5152/akd. 2014.5143.
- Akgul O, Baycan OF, Bulut U, Somuncu MU, Pusuroglu H, Ozyilmaz S, Gul M, Demir AR, Ylmaz E, Yazan S, Kokturk U, Cetin I, Uyarel H.  Long-term prognostic value of elevated pentraxin 3 in patients undergoing primary angioplasty for ST-elevation myocardial infarction. Coron Artery Dis. 2015; 26:592-7. doi: 10.1097/MCA.0000000000000280.
- Aslan M, Erturk M, Turen S, Uzun F, Surgit O, Ozbay Ozyilmaz S, Rifat Yildirim M, Faruk Baycan O, Uygur B, Yildirim A, Eksik A. Effects of percutaneous closure of atrial septal defect on left atrial mechanical and conduction functions. Eur Heart J Cardiovasc Imaging. 2014; 15:1117-1124. doi: 10.1093/ehjci/jeu089.
- Bolat I, Akgul O, Cakmak HA, Pusuroglu H, Somuncu U, Ozbey S, Ornek V, Erturk M, Gul M. The prognostic value of admission mean platelet volume to platelet count ratio (MPV/Plt) in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. Kardiol Pol. 2016; 74:346-55. DOI:10.5603/KP. a2015.0179.
- Ozturk D, Celık O, Akın F, Akturk F, Aslan S, Ozyılmaz SO, Bırand A, Yıldırım A.  Usefulness of the uric acid and CHA2DS2-VASC score in prediction of left atrial thrombosis in patients with mitral stenosis and sinus rhythm.Cardiol J. 2015;22:336-42. doi: 10.5603/CJ.a2014.0059.
- Pusuroglu H, Somuncu U, Bolat I, Akgul O, Yıldırım HA, Ozyilmaz SO, Ornek V, Surgit O, Karakurt H, Utkusavas A, Alagic N, Yıldırım A. Assessment of the relationship between endocan and obstructive sleep apnea severity. Arch Med Sci. 2020 Aug 3;16(6):1346-1352. doi: 10.5114/aoms.2020.97764.
- Bastug Gul Z, Akkaya E, Vuruskan E, Akgul O, Pusuroglu H, Surgit O, Ozbay Ozyilmaz S, Rodi Tosu A, Altug Cakmak H, Gode S, Gul M.  Comparison of periprocedural and long-term outcomes of proximal versus distal cerebral protection method during carotid artery stenting. Vasa. 2015;44:297-304. doi: 10.1024/0301-1526/a000445.
- Ozyilmaz I, Ergul Y, Tola HT, Saygi M, Ozturk E, Tanidir IC, Tosun O, Ozyilmaz S, Gul M, Guzeltas A, Odemis E, Ihsan B. Heart rate variability improvement in children using transcatheter atrial septal defect closure. Anatolian Journal of Cardiololgy 2016;16:290-5. DOI:10.5152/akd. 2015.5922.
- Ozturk D, Celik O, Satilmis S, Aslan S, Erturk M, Cakmak HA, Kalkan AK, Ozyilmaz S, Diker V, Gul M. Association between serum galectin-3 levels and coronary atherosclerosis and plaque burden/structure in patients with type 2 diabetes mellitus. Coron Artery Dis. 2015;26:396-401. doi: 10.1097/MCA.0000000000000252.
- Pusuroglu H, Akgul O, Erturk M, Bolat I, Tasbulak O, Ornek V, Gul M, Ozyilmaz SO, Yildirim HA, Kokturk U, Yilmaz E, Kalkan AK, Durmuş G. Assessment of the relationship between galectin-3 and ambulatory ECG-based microvolt T-wave alternans in sustained systodiastolic hypertension patients. Blood Press Monit. 2016;21:265-70. doi: 10.1097/MBP.0000000000000197.
- Arif Yalcin A, Faruk Akturk I, Celik O, Erturk M, Sabri Hancer V, Yalcin B, Isiksacan N, Uzun F, Ozbey Ozyilmaz S, Biyik I.  Coronary artery ectasia is associated with the c.894G>T (Glu298Asp) polymorphism of the endothelial nitric oxide synthase gene. Tohoku J Exp Med. 2014;232:137-44.
- Satilmisoglu MH, Gul M, Yildiz G, Akgul O, Kaya M, Cakmak HA, Akkaya E, Aslan S, Ameri MT, Ozbay Ozyilmaz S, Yildirim A. Prognostic Value of CHA2DS2-VASc Score in Patients with ST-Elevation Myocardial Infarction Who Underwent Primary Percutaneous Coronary Intervention. Acta Cardiol. 2016;71:663-669. doi: 10.2143/AC.71.6.3178184.
- Bolat I, Pusuroglu H, Surgit O, Somuncu U, Demir Y, Ozyilmaz S, Gungor A, Okulu Y. The Relation between Red Cell Distribution Width and Hypertension, Dipper Pattern and End-Organ Damage Independent from Vitamin B12, Folic Acid and Ferritin Levels. Int J Clin Exp Hypertens. 2018;1(1): 001-006.
- Gul M, Ozyılmaz SO, Bastug Gül Z, Kacmaz C, Satilmisoglu M.H, Evaluation of Cardiac Injury with Biomarkers and Echocardiography after Covid-19 Infection, Journal of Physiology Pharmacology 2022, DOI:10.26402/jpp 2022.1.09
- C, Satilmisoglu M.H, Gul M, Ozyılmaz S, Cizgici AY, Real Life Data for Major Adverse Cardiac Events in Patients With ST Elevation Myocardial Infarction Prasugrel Versus Ticagrelor, Journal of Physiology Pharmacology 2021,72,4, DOI:10.26402/jpp 2021.4.08
- Ozyilmaz S, Akgul O, Guzeltas A, Ozyilmaz I. Diagnosis of pentacuspid aortic valve with severe regurgitation using three-dimensional transesophageal echocardiography. Echocardiography. 2015;32:393-4. doi: 10.1111/echo.12752.
- Ozyilmaz I, Ergul Y, Ozyilmaz S, Guzeltas A. Junctional ectopic tachycardia in late period after early postoperative complete atrioventricular block: Messenger of return to normal sinus rhythm? Explanation with four case series. J Electrocardiol. 2017;50:378-382. doi: 10.1016/j.jelectrocard.2017.01.015.
- Karakus G, Ozyilmaz S, Zencirci E, Degirmencioglu A, Kiris A. An unusual type of partial anomalous pulmonary venous return with all pulmonary veins draining to left atrium (!). Int J Cardiol. 2016;15:173-175.  doi: 10.1016/j.ijcard.2016.08.055.
- Ozyilmaz I, Ozyilmaz S, Ergul Y, Akdeniz C, Tuzcu V. Catecholaminergic Polymorphic Ventricular Tachycardia: a Rare Cause of Cardiac Arrest Following Blunt Chest Trauma. Acta Cardiologica Sinica. 2015;31:361-364.
- Ermis E, Kahraman S, Ucar H, Ozbay Ozyılmaz S, Allahverdiyev S. Triple Coronary Artery Thrombosis Presenting as Acute Anterior ST-Segment Elevation Myocardial Infarction. Int J Angiol. 2017:1-5. DOI https://doi.org/ 10.1055/s-0037-1608959.
- Ozyilmaz I, Ozyilmaz S, Tosun O, Tola HT, Saygi M, Ergul Y. Atrial fibrillation in a healthy adolescent after heavy smoking of contraband cigarettes.Int J Adolesc Med Health. 2015;27:353-356. doi: 10.1515/ijamh-2014-0026
- Özbay Özyılmaz Sinem, Akgül Özgür, Kiriş Adem, Yıldırım Aydın, Bakır İhsan. Diagnosis of a rare combination of hypertrophic and left ventricular noncompaction cardiomyopathy using cardiac magnetic resonance imaging. Türk Kardiyoloji Derneği Arşivi, 2016; 44(5), 449, Doi: 10.5543/tkda.2016.94324.
- Satılmısoglu MH, Gul M, Ozyilmaz S, Cizgici AY, Real-lıfe data for major adverse cardıac events ın patıents wıth st-elevatıon myocardıal ınfarctıon prasugrel versus tıcagrelor, Journal of Physiology And Pharmacology 2021,72,4.,DOI: 10.26402/jpp.2021.4.08.
- Özyılmaz İ, Özyılmaz S, Ergül Y, Güzeltaş A.Author's Reply.Anatol J Cardiol 2015;15:855
- Gul M, Uslu N, Satılmısoglu H, Ozyılmaz SO. When should fQRS be evaluated as a noninvasive prognostic marker in patients undergoing primary PCI with 8 STEMI? Ann Noninvasive Electrocardiol. 2015;20:200-201. doi: 10.1111/anec.12239.
- Özyılmaz S, Püşüroğlu H. Author`s Reply - Confounding factors about microvolt T-wave alternans testing and life-threatening ventricular arrhythmias. Anatol J Cardiol 2018; 20: 00-00.
B) Ulusal Hakemli Dergilerde Yayınlanan Makaleler:
- Sinem Ozbay, İsa Ozyılmaz, Ali Uysal, Mehmet Hamidi, Osman Akın Serdar. Gece Şartlarında Hastane Ortamında Calışma Arteriyel Sertlik icin Risk Faktorudur. Haseki Tıp Bülteni 2012;50:93-5.
- Sinem Özyılmaz, İsa Özyılmaz, Osman Akın Serdar, Esra Uzaslan. Association between Arterial Stiffness and Acute Exacerbations in Patients with Chronic Obstructive Pulmonary Disease. Eurasian J Pulmonol 2014; 16: 89-93.
- Özbay Özyılmaz Sinem, Özyılmaz İsa, Osman Akın Serdar, Esra Uzaslan. Kronik Obstrüktif Akciğer Hastalığı olan Hastalarda Akut Atağın Şiddeti ile Ürik Asit ve Ürik Asit Kreatinin Oranı Arasındaki İlişki. Haseki Tıp Bülteni, 2013; 51(4), 147-150., Doi: 10.4274/Haseki.1162.
- Sinem Özbay Özyılmaz, Aydın Yıldırım. Primer perkütan koroner girişim. Kompleks perkütan koroner girişimler(Özel sayısı). Türkiye Klinikleri, 2012;5(6):1-16.
- Bayramoğlu S, Özbay S, Sayın N. Effect of Diastolic Heart Dysfunction Due to Hypertrophic Cardiomyopathy on Choroidal Thic
- High Honor Student, Uludağ University Faculty of Medicine (Grade Average: 3.62 / 4)
- "Dr. Ümit Aker, the Most Successful Article Awards of the Year 2018", Archives of the Turkish Society of Cardiology, Article: Evaluation of the association between serum uric acid level and the predicted risk score of sudden cardiac death in five years in patients with hypertrophic cardiomyopathy
- "The Best Interventional Case in the Category of Valvular Heart Diseases" OS-10 TAVI in a high surgical risk patient with pure severe aortic regurgitation. The National Interventional Cardiology Meeting, 5-8 October 2023; Antalya, Turkey
- ECFMG (Educational Commission for Foreign Medical Graduates) Certification
- Erasmus MC, Hands-on Cardiac CT Course, Rotterdam, Netherlands
- Amsterdam CMR Course, Amsterdam UMC, Netherlands
- 3D Echocardiography Expert Course, ESC-EACVI, Eindhoven, Netherlands
- ESC Level 1 Cardiogenic Shock School, Paris, France
- ESC Level 1 Certification in Cardiac CT
- ESC Level 1 Certification in Cardio-Oncology
- ESC Multimodality Imaging in Congenital Heart Disease
- ESC Guidelines and CME modules (2023"“2025)
