Learn about Colorectal Cancer (Colon), its definition, causes, and the main types of cancer that affect the colon and rectum, guiding treatment planning.

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Colorectal Cancer (Colon): Overview and Definition

Understanding Colorectal Cancer 

Colorectal cancer is a serious disease that begins in the large intestine (colon or rectum), often developing from small growths called polyps. It is one of the most common cancers affecting both men and women.

Over time, some polyps can become malignant, forming a tumor that invades the intestinal wall. Early detection through routine screening is crucial, as removing polyps before they turn cancerous can prevent the disease entirely.

The unified term “colorectal” is used because cancers of the colon and rectum share similar causes and treatment approaches.

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Colorectal Cancers

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The Colorectal Cancer (Colon) definition is the malignant growth of cells originating in the inner lining of the colon or the rectum. Almost all colorectal cancers are adenocarcinomas, which means they start in the glandular cells that produce mucus.

 

The term “colon” comes from the Greek word kolon, referring to the large intestine. Once the cancer is established, it can spread (metastasize) to nearby lymph nodes or distant organs, such as the liver or lungs, through the bloodstream.

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What It Is and Is Not

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It is essential to understand the difference between cancer and polyps. Polyps are growths on the lining of the colon that are typically non-cancerous when first found. Most polyps are adenomas, which means they have the potential to become cancerous.

  • Colorectal Cancer: Malignant and invasive cells that require surgery, chemotherapy, or radiation.
  • Polyps (Adenomas): Non-cancerous growths that can be easily removed during a colonoscopy. They are generally monitored or removed as a preventative measure.

A colonoscopy allows a doctor to view the entire colon. This is the most effective way to distinguish between a harmless polyp and an established, invasive cancer.

Main Categories

Colorectal cancer is mainly categorized by where it starts and how far it has spread. Understanding the location and stage is crucial for planning surgery and medical therapy.

Colon Cancer 

Cancer that starts in the long, upper section of the large intestine. Colon cancer typically involves surgery to remove the affected part of the bowel.

  • Location: Tumors can be found in the right colon (ascending), the transverse colon, or the left colon (descending).
  • Treatment: Treatment often involves surgery followed by chemotherapy, depending on whether the cancer has spread to the lymph nodes.

Rectal Cancer

Cancer that starts in the rectum, the last section of the large intestine, just before the anus.

Treatment: Rectal cancer often requires a combination approach, frequently starting with radiation and chemotherapy before surgery is performed. This is done to shrink the tumor.

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Types of Colorectal Cancer

The vast majority (over 95%) of types of Colorectal Cancer (Colon) are adenocarcinomas. However, these cancers are often categorized based on their underlying genetics and cell appearance, which guides treatment.

  • Microsatellite Instability (MSI): Tumors are tested for high MSI. This indicates problems with DNA repair genes and often predicts a good response to immunotherapy.
  • KRAS/NRAS/BRAF Mutations: These genetic mutations affect cell growth signaling. Finding these mutations helps doctors decide whether to use certain types of targeted therapy drugs.

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Related Organ Systems

Colorectal cancer directly affects the digestive system but often involves other critical organ systems due to its pattern of spread.

  • Digestive System: The cancer directly obstructs or causes bleeding in the large intestine.
  • Lymphatic System: Cancer cells frequently spread first to lymph nodes near the colon and rectum.
  • Hepatobiliary System (Liver): The liver is the most common site for distant metastasis of colorectal cancer, due to the direct blood flow from the colon.
  • Pulmonary System: The lungs are the second most common site for cancer spread, which is monitored with regular CT scans.

Importance in Medicine

The treatment and prevention of Colorectal Cancer (Colon) are of critical importance. It is one of the few cancers that can be reliably prevented through screening. Removing polyps is a form of primary cancer prevention.

Advances in surgical techniques and targeted drug therapies have dramatically improved survival rates, even for advanced disease. The emphasis on early screening and preventative care highlights the public health significance of this field.

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Subspecialty Areas

Colorectal cancer treatment is managed by a specialized, multidisciplinary team.

  • Colorectal Surgeon: The specialist who performs surgery to remove the affected section of the colon or rectum.
  • Medical Oncologist: Manages systemic treatments, including chemotherapy, targeted therapy, and immunotherapy drugs.
  • Gastroenterologist: The doctor who performs colonoscopies for both screening and post-treatment surveillance.
  • Radiation Oncologist: Provides radiation therapy, which is crucial for treating rectal cancer before surgery.

The Role of Surgeons

What do Colorectal Cancer (Colon) surgeons do? These surgeons specialize in complex operations on the colon and rectum. They remove the cancerous section of the bowel and reconnect the remaining healthy ends.

When should I see a Colorectal Cancer (Colon) surgeon? You should see a surgeon immediately after diagnosis, as surgery is the primary curative treatment for early-stage disease. They assess whether a minimally invasive approach is possible.

Colorectal Cancer vs. Inflammatory Bowel Disease

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What is the difference between Colorectal Cancer (Colon) and Inflammatory Bowel Disease (IBD)? IBD (like Crohn’s disease or ulcerative colitis) involves chronic inflammation. While IBD is not cancer, chronic inflammation significantly increases the risk of developing cancer over time. Treatment for IBD focuses on controlling inflammation, while cancer treatment focuses on eradication.

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FREQUENTLY ASKED QUESTIONS

What is Colorectal Cancer(Colon), and what do Colorectal Cancer(Colon) surgeons do?

It is cancer that starts in the large intestine. Surgeons remove the cancerous part of the bowel and reconnect the remaining healthy tissue.

The treatments, surgery, chemotherapy, and radiation, target the malignant tumor in the colon or rectum to eliminate it and prevent its spread.

Over 95% are adenocarcinomas, which are categorized based on their location (colon or rectum) and specific genetic mutations.

You should see a surgeon immediately after a cancer diagnosis, as surgery is the primary curative treatment option for non-metastatic disease.

Polyps are often non-cancerous growths that can be removed preventively. Cancer is the malignant, invasive stage of the disease.

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