Infectious Diseases and Clinical Microbiology

Infectious Diseases: Diagnosis, Treatment & Travel Medicine

Infectious diseases specialists diagnose and treat infections from bacteria, viruses, fungi, and parasites, focusing on fevers, antibiotics, and vaccines.

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Supportive Care and Therapeutic Interventions

Supportive Care and Therapeutic Interventions

There is no medicine that directly kills the measles virus after infection. At Liv Hospital, treatment focuses on supportive care—managing symptoms, preventing complications, and helping the immune system fight the virus. Care is adjusted based on age, nutrition, and immune strength. Most healthy people recover with basic support, but high-risk groups need special attention to avoid serious illness or death.

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Supportive Therapy

Supportive Therapy

The foundation of measles management is robust supportive care to maintain physiological stability during the acute phase.

  • Antipyretics: High fevers are managed with medications such as acetaminophen (paracetamol) or ibuprofen. This reduces patient discomfort and the risk of febrile seizures in young children. Aspirin is strictly contraindicated in children and adolescents with viral infections due to the risk of Reye’s syndrome, a potentially fatal condition affecting the liver and brain.
  • Hydration: Intense fever, sweating, and potential gastrointestinal losses (diarrhea/vomiting) increase the risk of dehydration. Oral rehydration therapy with electrolyte solutions is encouraged. In severe cases where oral intake is compromised due to lethargy or severe stomatitis, intravenous fluid resuscitation is administered.

Respiratory Support: For uncomplicated cases, humidified air can help soothe the cough and inflamed respiratory passages. When measles pneumonia develops, supplemental oxygen or respiratory support in an intensive care setting may be required.

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Vitamin A Therapy

Vitamin A Therapy

Giving Vitamin A is a key, proven part of measles treatment. Measles quickly uses up the body’s Vitamin A, no matter how healthy the person was before. Low Vitamin A levels are linked to more severe illness, worse eye damage, and slower healing of the body’s linings.

  • Protocol: The World Health Organization and Liv Hospital protocols recommend administering two doses of Vitamin A supplements, given 24 hours apart, to all children diagnosed with measles. This is standard practice regardless of the country of origin or suspected nutritional status.

Mechanism: Vitamin A is essential for the integrity of epithelial cells and the proper functioning of the immune system. Restoring these levels helps repair the damage to the eyes, lungs, and gut, significantly reducing the risk of blindness and measles-related death.

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Management of Bacterial Superinfections

Management of Bacterial Superinfections

The measles virus suppresses the immune system and damages the respiratory lining, creating an ideal environment for secondary bacterial infections. Antibiotics are not used prophylactically for measles itself but are prescribed promptly if bacterial complications arise.

  • Pneumonia: If a patient develops signs of bacterial pneumonia (e.g., worsening cough, difficulty breathing, new fever spike), broad-spectrum antibiotics are initiated.
  • Otitis Media: Bacterial ear infections are common complications and are treated with appropriate oral antibiotics.

Corneal Ulcers: Secondary bacterial infections of the eye require topical antibiotics to prevent permanent scarring and vision loss.

Ribavirin and Antiviral Considerations

Ribavirin and Antiviral Considerations

While there is no standard antiviral for measles, Ribavirin—a broad-spectrum antiviral medication—has been used off-label in experimental or compassionate-use settings for severe measles pneumonia or encephalitis, particularly in severely immunocompromised patients. However, its efficacy has not been definitively proven in controlled trials, and its use is determined on a case-by-case basis by infectious disease specialists, weighing potential benefits against potential risks.

Isolation and Infection Control

Isolation and Infection Control

Management also involves protecting others. Patients hospitalized with measles require strict airborne precautions.

  • Negative Pressure Isolation: Patients are placed in rooms where the air is filtered and prevented from flowing into hallways.
  • PPE: Healthcare staff must wear N95 respirators.

Visitor Restrictions: Only immune individuals may have contact with the patient. Isolation is typically maintained for 4 days after the onset of the rash in healthy patients, and for the duration of the illness in immunocompromised patients.

Care for Immunocompromised Patients

Care for Immunocompromised Patients

Patients with compromised immune systems (e.g., those on chemotherapy, HIV positive, or transplant recipients) are at the highest risk for fatal giant cell pneumonia or encephalitis, often without developing the characteristic rash. Management in these cases is aggressive, usually involving the use of Intravenous Immunoglobulin (IVIG) to provide passive antibodies to help fight the virus, alongside intensive monitoring.

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FREQUENTLY ASKED QUESTIONS

Why is Vitamin A given to children with measles?

Measles causes a rapid drop in Vitamin A levels, even in well-nourished children. Vitamin A is crucial for maintaining eye and immune system health. Giving high-dose Vitamin A supplements helps prevent severe eye damage (including blindness), speeds up recovery, and has been proven to significantly reduce the risk of dying from measles complications.

No, antibiotics cannot cure measles because measles is a viral infection, and antibiotics only kill bacteria. However, antibiotics are essential if a patient develops a secondary bacterial infection caused by measles complications, such as bacterial pneumonia, ear infections, or eye infections. They treat the complications, not the virus itself.

Measles pneumonia is treated with supportive care, including oxygen therapy and fluids. If there is evidence of a secondary bacterial infection causing the pneumonia, antibiotics are prescribed. In very severe cases, particularly in people with weakened immune systems, doctors might consider antiviral medications or immunoglobulins, though this is specialized care.

Children and teenagers with viral infections like measles (or chickenpox/flu) should never take aspirin or products containing aspirin. Using aspirin during a viral illness is linked to Reye’s syndrome, a rare but life-threatening condition that causes sudden liver damage and brain swelling. Safer alternatives, such as acetaminophen (paracetamol) or ibuprofen, are used for fever.

To help with photophobia (light sensitivity) and eye irritation, it is recommended to keep the patient’s room lights dimmed. Using warm, damp cloths to clean the eyes and remove crusting gently can provide relief. Avoiding screens and bright sunlight is also helpful until the conjunctivitis resolves.

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