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Respiratory Syncytial Virus: Treatment and Care

Respiratory Syncytial Virus: Treatment and Care

The therapeutic landscape for RSV is predominantly supportive. Despite decades of research, there is no “magic bullet” antiviral cure for established infection in the general population. The primary objective of care is to support respiratory function and hydration until the body’s immune system clears the virus and the airway epithelium regenerates. Treatment intensity is graded: mild cases are managed at home with comfort measures, while severe cases require hospitalization for oxygen therapy, fluid support, and potentially mechanical ventilation. At Liv Hospital, we adhere to strict antibiotic stewardship, avoiding unnecessary medications while providing rigorous supportive care.

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Fluid Management and Nutrition

Hydration is the first line of defense in RSV management. Respiratory distress creates a high-output state where fluid is lost through rapid breathing, while nasal congestion limits intake.

  • Enteral Support: Whenever possible, the gut is used. Nasogastric (NG) tubes allow for the delivery of breast milk or formula to infants who are too tachypneic to suck safely but do not require intubation. This preserves gut integrity and provides better nutrition than IV fluids.
  • Intravenous Fluids: Isotonic fluids are used if enteral feeding is contraindicated due to aspiration risk. Careful calculation is required to avoid fluid overload, which can worsen pulmonary edema.
  • Hyponatremia Watch: Because RSV can trigger SIADH (water retention), fluids are often restricted to maintenance levels, and sodium levels are monitored.
  • Feeding Frequency: For milder cases, smaller, more frequent feeds are recommended to prevent a full stomach from pushing on the diaphragm and impeding breathing.

Suctioning Before Feeds: Clearing the nose immediately before feeding is a critical care step to facilitate coordination.

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Oxygen Therapy Modalities

Oxygen Therapy Modalities

Oxygen is a drug and is titrated carefully. The goal is to prevent hypoxia-induced organ damage while avoiding oxygen toxicity.

  • Low-Flow Nasal Cannula: Standard oxygen delivery for mild hypoxemia.
  • Heated Humidified High-Flow Nasal Cannula (HFNC): This is a cornerstone of modern bronchiolitis care. It delivers heated, humidified air/oxygen at high flow rates (e.g., 2 L/kg/min). This washes out dead-space CO2, reduces airway resistance, and provides a small amount of positive end-expiratory pressure (PEEP) to keep airways open.
  • CPAP (Continuous Positive Airway Pressure) provides stronger distending pressure to prevent alveolar collapse and is the next step if HFNC fails.
  • Weaning Protocols: Oxygen is weaned gradually based on sleep and activity saturation trends to ensure safety before discharge.
  • Humidification: All oxygen delivered to infants should be humidified to prevent secretions from drying and forming plugs.

Mechanical Ventilation Strategies

For infants who develop respiratory failure (severe apnea or CO2 retention), intubation is necessary. The ventilation strategy for RSV focuses on avoiding barotrauma (pressure injury) and air trapping.

  • Long Expiratory Time: Ventilator settings are adjusted to allow plenty of time for air to exit the lungs, preventing “auto-PEEP” or air stacking.
  • Permissive Hypercapnia: Clinicians often accept higher CO2 levels (so long as pH remains acceptable) rather than using high pressures that could damage the lungs.
  • Suctioning Protocols: Frequent, careful endotracheal suctioning is vital to remove the copious sloughed debris typical of RSV.
  • Sedation: Adequate sedation is required to prevent the infant from “fighting” the ventilator, which worsens air trapping.
  • Extubation Readiness: Assessing the leak around the tube is essential, as airway edema can cause stridor upon removal.

Bronchodilators and Steroids (Deprescribing)

Bronchodilators and Steroids (Deprescribing)

A primary focus of modern care is stopping the use of ineffective medications. Historical practices of using albuterol (bronchodilators) and systemic steroids have been shown to provide no benefit in typical RSV bronchiolitis.

  • Albuterol/Salbutamol: These drugs work on smooth muscle constriction. RSV obstructs debris and edema, not constriction. Routine use is not recommended unless there is a strong family history of asthma or atopy, and a monitored trial shows clear benefit.
  • Corticosteroids: Steroids do not reduce viral load or hospital length of stay in RSV. They are currently recommended against, as they may prolong viral shedding.
  • Hypertonic Saline: Nebulized 3% saline helps draw water into the airway, rehydrating the mucus layer and improving clearance. It is one of the few therapies with some evidence for shortening hospital stays in inpatients.
  • Antibiotics: Strictly avoided unless there is evidence of bacterial coinfection.

Cough Medicine: Dangerous and ineffective in infants; contraindicated.

Ribavirin and Targeted Antivirals

Ribavirin is a nucleoside analog antiviral. Its use is extremely limited due to its high cost, the difficulty of administration (requiring a specialized aerosol generator hood running for 12-18 hours/day), and potential teratogenicity to healthcare staff.

  • Indications: Reserved for life-threatening RSV infection in severely immunocompromised patients (e.g., bone marrow transplant recipients or lung transplant patients).
  • Mechanism: It interferes with viral RNA polymerase, inhibiting replication.
  • Safety: Pregnant healthcare workers must not be exposed to Ribavirin aerosol.
  • Efficacy: While it reduces viral shedding, its impact on mortality is variable.
  • Future Antivirals: Research is ongoing into fusion inhibitors and polymerase inhibitors that may offer oral treatment options in the future.

Chest Physiotherapy

Chest Physiotherapy

Chest physiotherapy (CPT) involving percussion and vibration was once standard but is now discouraged. In RSV, the airways are floppy and prone to collapse. Percussion can actually increase distress and does not improve the clearance of the specific type of mucus plugs found in bronchiolitis. However, careful positioning and mobilization of older patients are encouraged to prevent atelectasis.

Discharge Criteria and Home Care

The transition to home care is a critical phase. Discharge criteria include stable oxygenation (usually >90% on room air, including during sleep), adequate oral intake to prevent dehydration (at least 75% of normal), and capable caregivers.

  • Caregiver Education: Parents are taught to use bulb suction, recognize signs of respiratory distress (retractions, tachypnea), and set hydration goals.
  • Tobacco Smoke: Strict counseling on avoiding smoke exposure is provided, as smoke paralyses cilia and worsens recovery.
  • Follow-up: A visit to the pediatrician within 48-72 hours is typically arranged to ensure weight gain and lung recovery.
  • Expected Course: Parents are counseled that the cough may persist for 2-4 weeks and does not require re-evaluation unless distress returns.
  • Readmission Risks: Identifying social determinants of health that might lead to readmission is part of discharge planning.

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FREQUENTLY ASKED QUESTIONS

Why can’t the doctor give medicine to stop the cough?

Coughing is the body’s way of clearing the mucus and dead cells from the lungs. Stopping the cough with medicine could trap this debris and lead to pneumonia.

Nebulizers work for asthma by relaxing muscles. In RSV, the problem is swelling and mucus, not tight muscles, so these treatments usually don’t help and can cause side effects like a fast heart rate.

For children over 1 year old, honey can help soothe the throat and cough. However, honey must NEVER be given to babies under 1 year due to the risk of infant bot

Suctioning uses a bulb or tube to suck mucus out of the nose. You should do it before feeding and sleeping, but not too often, as doing it too much can swell the nose and make congestion worse.

The airways take a long time to heal. It is normal for a baby to have a mild wheeze or cough for 2 to 4 weeks after RSV, as long as they are breathing comfortably and eating well.

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