Pulmonology focuses on diagnosing and treating lung and airway conditions such as asthma, COPD, and pneumonia, as well as overall respiratory health.

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The Great Imitator

The clinical presentation of tuberculosis is notoriously variable. It is often called “the great imitator” because its symptoms can mimic many other conditions, including lung cancer, pneumonia, fungal infections, and autoimmune diseases. This variability often leads to delays in diagnosis, during which the patient remains infectious. At Liv Hospital, we emphasize a comprehensive evaluation of symptoms in the context of a patient’s specific risk profile. Understanding the nuances of tuberculosis symptoms is the first line of defense in identifying potential cases.

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Pulmonary Tuberculosis: The Classic Presentation

While symptoms can be vague, a constellation of respiratory and systemic signs usually points to pulmonary involvement.

The Evolution of the Cough

  • Early Stage: The cough may start as a dry, irritating, non-productive cough, easily mistaken for a lingering cold or allergy.
  • Progression: As the disease advances and tissue necrosis occurs, the cough becomes productive. Patients produce sputum (phlegm) that may be mucoid (clear/white) or purulent (yellow/green).
  • Chronic Nature: The key differentiator is duration. A cough lasting 2-3 weeks or more, especially if it fails to resolve with standard antibiotics, is a red flag for pulmonary tuberculosis.

Hemoptysis: A Warning Sign

Coughing up blood (hemoptysis) is one of the most alarming signs of tuberculosis.

  • Mechanism: It results from the erosion of caseous granulomas into pulmonary blood vessels.
  • Presentation: It can range from blood-streaked sputum to massive, life-threatening hemorrhage (Rasmussen’s aneurysm). While classically associated with advanced disease/cavitation, it can sometimes be an early symptom.

Chest Pain and Dyspnea

  • Pleuritic Pain: Sharp, stabbing pain worsened by breathing or coughing indicates that the inflammation has spread to the pleura (the lung lining).
  • Dull Ache: Some patients report a vague, persistent heaviness or ache in the chest.
  • Shortness of Breath: Dyspnea is usually a sign of extensive lung destruction, large pleural effusion, or miliary tuberculosis. It indicates a significant loss of functional lung capacity.
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Systemic "Consumption" Symptoms

The systemic inflammatory response to the infection drives a hypermetabolic state that “consumes” the body.

  • Fever: Typically low-grade and intermittent initially, often rising in the late afternoon or evening. It may be absent in older people or in those who are immunosuppressed.
  • Night Sweats: Profuse, drenching sweats that require changing bedclothes are a hallmark of active tuberculosis disease. This is a cytokine-mediated response to the chronic infection.
  • Weight Loss: Significant, unintentional weight loss is characteristic. It results from a combination of anorexia (loss of appetite), nausea, and the high energy cost of the chronic inflammatory response.
  • Fatigue: profound, unrelenting exhaustion and malaise (a general feeling of being unwell) are often the earliest and most persistent complaints.

Extrapulmonary Symptoms: A Diagnostic Challenge

When TB affects organs other than the lungs, the symptoms are site-specific, making diagnosis difficult without a high index of suspicion.

  • Lymph Node TB (Scrofula): Painless, slow-growing swelling of lymph nodes, usually in the neck (cervical chain). The nodes may become matted together and eventually rupture through the skin, forming a chronic draining sinus.
  • Bone and Joint TB (Pott’s Disease): Chronic back pain is the most common symptom of spinal TB. It can progress to spinal deformity (kyphosis or “gibbus”) and neurological deficits (paralysis) due to cord compression. Joint TB presents as a chronic monoarthritis (swelling/pain in a single joint, like the knee or hip).
  • Genitourinary TB: Sterile pyuria (white blood cells in urine but negative standard bacterial cultures), blood in urine (hematuria), flank pain, or infertility in women (due to fallopian tube scarring) and epididymitis in men.
  • TB Meningitis: Begins with vague headache and low-grade fever, progressing over weeks to stiff neck, confusion, cranial nerve palsies (vision changes, facial droop), coma, and death.
  • Abdominal TB: Chronic abdominal pain, ascites (fluid in the abdomen), and intestinal obstruction, often mimicking Crohn’s disease or ovarian cancer.

The Risk Factor Profile

Understanding who is at risk is as important as recognizing symptoms.

The Biological Risks

  • HIV/AIDS: The single most substantial risk factor for progression to active disease. HIV depletes CD4 cells, which are essential for maintaining the granuloma structure. Coinfection accelerates the course of both diseases.
  • Diabetes Mellitus: Diabetics have a 3-times higher risk of developing active TB due to impaired immune function.
  • Silicosis: Miners and workers exposed to silica dust have damaged lung macrophages, making them highly susceptible.
  • TNF-Alpha Inhibitors: Patients taking biologics (such as infliximab or adalimumab) for rheumatoid arthritis or Crohn’s disease are at high risk of reactivation of latent tuberculosis, as TNF-alpha is the key cytokine that holds the granuloma together.
  • Chronic Kidney Disease: Uremia suppresses cellular immunity.
  • Malnutrition: Protein-calorie malnutrition and Vitamin D deficiency compromise immune defenses.

    The Social and Environmental Risks

    Tuberculosis is a social disease, thriving in conditions of poverty and overcrowding.

    • Close Contacts: Prolonged exposure to a person with infectious pulmonary tuberculosis (e.g., household members) is the primary route of transmission.
    • Congregate Settings: Prisons, homeless shelters, and nursing homes provide the ideal environment for airborne transmission.
    • Homelessness: Associated with malnutrition, substance abuse, and crowded shelters.
    • Substance Abuse: Alcoholism and IV drug use weaken the immune system and are often linked to poor social circumstances.

    Demographic Risks

    • Geography: Birth or residence in high-burden countries (Sub-Saharan Africa, Southeast Asia, Eastern Europe).
    • Travel: Extended travel to endemic regions increases risk.
    • Age: A bimodal distribution of infants/young children (immature immunity) and older people (waning immunity) is most vulnerable.

Latency and Reactivation Dynamics

    • The Reservoir: About one-quarter of the world’s population has latent tuberculosis.
    • Lifetime Risk: For a healthy person with latent infection, the lifetime risk of reactivation is 5-10%, with the highest risk in the first 2 years after infection.
    Trigger Events: Any event that suppresses immunity, such as stress, new medication, aging, or cancer, can trigger reactivation decades after the initial exposure.

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Assoc. Prof. MD. Engin Aynacı Assoc. Prof. MD. Engin Aynacı Pulmonology Overview and Definition
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FREQUENTLY ASKED QUESTIONS

Is a fever always present with TB?

A urologist is a surgeon trained to treat conditions of the urinary tract in both men and women. A urogynecologist has specific training in female pelvic medicine and reconstructive surgery, focusing on conditions like bladder prolapse and female incontinence.

Yes, especially in HIV-positive patients or those with extrapulmonary TB, the chest X-ray can appear normal even when the patient is symptomatic and ill.

They overlap significantly (cough, weight loss, blood in sputum), but TB is often accompanied by fever and night sweats, while cancer is not; a biopsy or culture is needed to tell them apart.

Smoking does not “cause” TB (the bacteria do), but it damages the lungs’ defenses, making you much more likely to get infected if exposed and more likely to develop active disease.

Night sweats are caused by the release of specific inflammatory proteins (cytokines) by your immune system as it fights the bacteria, particularly tumor necrosis factor (TNF).

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