Pulmonology focuses on diagnosing and treating lung and airway conditions such as asthma, COPD, and pneumonia, as well as overall respiratory health.
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Treating tuberculosis is one of the most challenging endeavors in infectious disease medicine. Unlike typical bacterial infections, TB organisms exist in different metabolic populations: rapidly growing extracellular bacteria, slowly growing intracellular bacteria, and dormant “persisters” within caseous lesions. A single antibiotic cannot kill all these populations. Therefore, successful tuberculosis treatment relies on the principle of multidrug therapy taken for a prolonged period to ensure sterilization and prevent relapse. At Liv Hospital, we adhere to strict international guidelines (WHO/CDC) while providing the personalized support patients need to complete this arduous journey.
The standard regimen for drug-susceptible pulmonary TB is a 6-month course divided into two phases.
The goal is to rapidly kill the actively dividing bacteria, resolve symptoms, and render the patient non-infectious. It involves four first-line tuberculosis drugs taken daily:
The goal is to eliminate the remaining persistent bacteria to prevent relapse. If the bacteria are fully susceptible, the regimen is simplified to two drugs daily:
Note: Treatment is extended to 9 months or longer for bone/joint TB, CNS TB, or if sputum culture remains positive after 2 months.
Treating LTBI is a critical preventative measure to stop future active disease. Since the bacterial load is low, fewer drugs are needed.
When bacteria are resistant to Isoniazid and Rifampin (MDR-TB), the treatment becomes exponentially more complex, toxic, and expensive.
Directly Observed Therapy (DOT) is the standard of care. A healthcare worker watches the patient swallow every dose. This is not about mistrust but about ensuring cure and preventing resistance.
Regular monitoring is mandatory to manage the toxicity of these potent drugs.
-Taking effective therapy for 2-3 weeks.
-Clinical improvement.
-Three consecutive negative sputum smears.
TB is a disease of catabolism.
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This is a harmless and expected side effect of Rifampin; it dyes all body fluids (urine, sweat, tears) orange. Do not wear soft contact lenses as they will be permanently stained.
You should be very cautious. Since the liver and your TB meds process Tylenol are already stressing your liver, combining them increases the risk of liver damage. Ask your doctor first.
Missing doses allow the bacteria to regrow and mutate. If you miss doses, your treatment may need to be restarted from the beginning, extended, or changed to more potent drugs.
Yes, MDR-TB is curable, but the success rate is lower (about 50-70% globally) than for standard TB, and the treatment is much more complex for the patient. Early diagnosis is key.
Surgery is rarely needed today, but may be used to remove a destroyed lung lobe, drain a persistent abscess, or stabilize a spine damaged by Pott’s disease.
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