What is Urology?

Urology: Urinary & Reproductive Disease Diagnosis & Treatment

Urology treats urinary tract diseases in all genders and male reproductive issues, covering the kidneys, bladder, prostate, urethra, from infections to complex cancers.

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Symptoms and Risk Factors

Laser Lithotripsy

The Clinical Manifestation of Urolithiasis

Laser Lithotripsy is a treatment for urinary stones. Patients come to the Urology Department at Liv Hospital when they have symptoms caused by stones blocking the urinary tract, irritating the lining, or causing infection. Symptoms can vary widely, from no symptoms at all to severe pain. Doctors decide to use laser treatment based on how serious the symptoms are and whether the stone threatens kidney health.

Renal Colic: The Hallmark of Obstruction

The most distinct and distressing symptom associated with urinary stones is renal colic. This pain syndrome is a direct result of the obstruction of urine flow. When a stone lodges in the ureter, it blocks the drainage of urine from the kidney. This causes the renal pelvis to distend and stretches the renal capsule, which is rich in nerve endings.

  • Renal colic usually starts suddenly with severe, changing pain. The pain often begins in the side of the back, between the ribs and hip. Unlike regular back pain, resting does not help. Patients often feel restless and may pace or move around trying to find relief.
  • Radiation Patterns: As the stone migrates down the ureter, the pain radiates anteriorly and inferiorly. It moves from the flank to the lower abdominal quadrant and eventually to the groin, testicle, or labia. This migratory pattern follows the dermatomes of the spinal nerves and serves as a clinical tracker of the stone’s progress.

Autonomic Response The severe pain often triggers a profound autonomic response. Nausea and vomiting are frequent concomitants of renal colic, resulting from shared innervation between the kidneys and the gastrointestinal tract via the celiac ganglion.

Systemic and Localized Symptoms

Besides severe pain, stones can cause other physical symptoms.

  • Hematuria, blood in the urine, is a classic sign of urolithiasis. As the jagged, crystalline surface of the stone moves, it abrades the delicate urothelium lining the kidney and ureter. This bleeding may be grossly visible, pink or red urine, or microscopic, detected only via laboratory analysis.
  • Lower Urinary Tract Symptoms. When a stone reaches the distal ureter near the bladder’s entrance, it can irritate the detrusor muscle. This mimics the symptoms of a urinary tract infection, presenting as urinary frequency, urgency, dysuria, and painful urination.
  • Infectious Indicators: If a stone blocks urine and bacteria are present, it can quickly become a medical emergency. This can lead to a kidney infection or even sepsis. Signs include high fever, chills, shaking, and cloudy urine. In these cases, doctors must drain the kidney and stabilize the patient before doing laser lithotripsy.

The Metabolic and Environmental Risk Landscape

Laser Lithotripsy

Stone formation is a complex physicochemical process driven by urine supersaturation. Understanding the risk factors is essential for identifying patients who require laser lithotripsy and for implementing strategies to prevent recurrence.

  • Dehydration and Fluid Balance. The most universal risk factor is low urine volume. Inadequate fluid intake leads to concentrated urine, where stone-forming minerals like calcium and oxalate are forced to crystallize due to a lack of solvent. Individuals living in hot, arid climates or those with physically demanding occupations are at significantly higher risk due to extra-renal fluid loss.
  • Dietary Influences Modern dietary patterns play a substantial role in lithogenesis. High sodium intake increases urinary calcium excretion. Excessive consumption of animal protein imposes an acid load on the kidneys, reducing urinary citrate, a natural inhibitor of stones, and increasing uric acid levels. Conversely, a diet low in fruits and vegetables deprives the body of alkali and fluid necessary for prevention.
  • Metabolic Syndrome and Obesity. There is a strong, bidirectional relationship between metabolic syndrome and stone disease. Insulin resistance alters urine pH, making it more acidic. This environment is highly conducive to the formation of uric acid stones. Obesity also correlates with increased excretion of oxalate and uric acid, compounding the risk.

Anatomical and Genetic Predispositions

Specific individuals are biologically predisposed to recurrent stone formation due to structural or genetic factors.

  • Anatomical Anomalies: Structural issues that impede the drainage of urine from the kidney create localized stasis. Stagnant urine allows crystals to aggregate and grow. Conditions such as horseshoe kidney, ureteropelvic junction UPJ obstruction, and medullary sponge kidney are associated with a high stone burden often requiring endoscopic management.
  • Genetic Disorders. Specific hereditary conditions lead to aggressive stone disease. Cystinuria is a genetic defect in amino acid transport that causes the formation of hard cystine stones. Primary Hyperoxaluria leads to massive oxalate excretion and potential kidney failure. These patients typically require multiple laser interventions throughout their lifetime.

Symptoms and Causes

Urological conditions can manifest in a variety of ways, ranging from mild discomfort to severe pain or visible physical changes. Because the urinary tract is vital for waste elimination, any disruption in its function typically produces noticeable symptoms. Recognizing these warning signs is critical for early intervention, particularly in cases of malignancy or obstruction where delays can lead to irreversible kidney damage.

Common Urinary Symptoms (LUTS)

Lower Urinary Tract Symptoms (LUTS) are among the most common reasons patients seek urological care. These include:

  • Frequency: The need to urinate more often than normal, often with small volumes.
  • Urgency: A sudden, compelling urge to urinate that is difficult to defer.
  • Nocturia: The need to wake up one or more times during the night to urinate.
  • Dysuria: Pain, burning, or discomfort during or immediately after urination.
  • Incontinence: The involuntary leakage of urine. This is often categorized as “stress incontinence” (leakage during coughing or sneezing) or “urge incontinence” (leakage following a sudden urge).

Pain and Physical Changes

  • Hematuria: The presence of blood in the urine. This is a cardinal sign in urology. It may be “gross” (visible to the naked eye, turning urine pink, red, or brown) or “microscopic” (detected only during a urinalysis). Hematuria should never be ignored, as it can indicate infection, stones, or cancer.
  • Renal Colic: Severe, sharp pain usually felt in the flank (side of the back) that radiates to the groin. This is the classic presentation of a passing kidney stone.
  • Testicular Pain or Masses: Any lump, enlargement, or pain in the testicles requires immediate evaluation to rule out testicular cancer or torsion.
  • Retention: The inability to empty the bladder, or at all. Acute urinary retention is a painful medical emergency.

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FREQUENTLY ASKED QUESTIONS

Why does the pain of a kidney stone come in waves?

Colic, a pain characterized by waves, is caused by the peristaltic action of the ureter. The ureter is a muscular tube that contracts rhythmically to push urine toward the bladder. When it contracts against an obstructing stone, the muscle spasms, causing intense pain. As the muscle relaxes between contractions, the pain may temporarily subside.

Yes, stones within the kidney that are not blocking urine flow can be asymptomatic. These are often called silent stones. However, they can still cause long-term damage by growing large, harboring chronic infection, or causing slow loss of kidney function, which is why they may still be treated with laser lithotripsy.

Obesity is linked to metabolic changes that alter urine chemistry. It is often associated with insulin resistance, which creates highly acidic urine, favoring the formation of uric acid stones. Additionally, individuals with higher body mass index usually excrete higher levels of calcium and oxalate, the building blocks of the most common rocks.

While alarming, blood in the urine is a common and expected symptom of a stone that has scratched the lining of the urinary tract. However, if the bleeding is heavy, with clots, or accompanied by fever and chills, it becomes a medical emergency, indicating a potential infection behind the obstruction and requiring immediate medical attention.

While hydration is key, some individuals have metabolic abnormalities that predispose them to stone formation regardless of fluid intake. This could be due to hypercalciuria, which causes excess calcium to be excreted in the urine; hypocitraturia, a lack of natural stone inhibitors; or genetic conditions. These patients require a detailed metabolic workup and often require specific medications in addition to dietary changes.

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