Gastroenterology covers the digestive system. It focuses on diagnosing, treating, and managing conditions of the stomach, intestines, liver, and pancreas.

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Treatment and Management

Cirrhosis

While the fibrotic scarring of cirrhosis is largely irreversible, the clinical course of the disease can be significantly altered. The goals of treatment at Liv Hospital are threefold: to treat the underlying cause to prevent further damage, to manage the complications of portal hypertension to prevent hospitalization, and to optimize the patient for liver transplantation if indicated. We employ a multidisciplinary strategy involving hepatologists, dietitians, and interventional radiologists to stabilize the patient’s condition and improve quality of life.

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Treating the Underlying Etiology

Cirrhosis

Halting the injury is the most effective way to preserve remaining liver function.

  • Alcohol Cessation:
    Total abstinence is non-negotiable for alcohol-associated cirrhosis. Even small amounts can be toxic to a cirrhotic liver. Medical support, counseling, and rehabilitation programs are integral to the treatment plan.
  • Antiviral Therapy:
    For Hepatitis C, Direct-Acting Antivirals (DAAs) can cure the infection in over 95% of cases, halting inflammation and sometimes leading to regression of fibrosis. For Hepatitis B, oral antivirals suppress the virus to undetectable levels.
  • Metabolic Management:
    For MASLD, weight loss of 7-10% through diet and exercise can reduce liver fat and inflammation. Control of diabetes and hyperlipidemia is essential.
  • Immunosuppression:
    Autoimmune hepatitis is treated with corticosteroids (prednisone) and azathioprine to suppress the immune system’s attack on the liver.
  • Chelation and Phlebotomy: For Wilson’s disease, copper-chelating agents are used. For Hemochromatosis, regular phlebotomy removes excess iron.
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Management of Ascites and Edema

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Fluid retention is the most common complication requiring management.

  • Sodium Restriction:
    A low-sodium diet (typically less than 2,000 mg per day) is the cornerstone of therapy to prevent fluid re-accumulation.
  • Diuretic Therapy:
    A combination of Spironolactone (an aldosterone antagonist) and Furosemide (a loop diuretic) is typically prescribed to help the kidneys excrete excess fluid. Doses are titrated carefully to avoid kidney injury.
  • Therapeutic Paracentesis:
    For large-volume ascites (tense ascites) that causes difficulty breathing, a needle is inserted into the abdomen to drain liters of fluid. Albumin infusions are often given simultaneously to prevent circulatory collapse.
  • TIPS (Transjugular Intrahepatic Portosystemic Shunt): For refractory ascites that does not respond to diuretics, a TIPS procedure may be performed. This involves placing a stent through the liver to connect the portal vein to the hepatic vein, bypassing the scarring and reducing pressure.

Management of Varices and Bleeding

Cirrhosis
  • Preventing hemorrhage is a critical safety goal.

    • Beta-Blockers:
      Non-selective beta-blockers (like Propranolol, Nadolol, or Carvedilol) are prescribed to lower pressure in the portal vein and reduce the risk of variceal rupture.
    • Endoscopic Band Ligation (EVL):
      During endoscopy, small rubber bands are placed around enlarged varices to strangle them, causing them to clot and fall off. This is done serially until the varices are eradicated.
    • Emergency Management:
      Active bleeding requires urgent endoscopic therapy, vasoactive drugs (Octreotide), and antibiotics.

Management of Hepatic Encephalopathy (HE)

Cirrhosis
  • Treating confusion involves reducing the production and absorption of ammonia in the gut.

    • Lactulose:
      This non-absorbable sugar acts as a laxative. It acidifies the gut, converting ammonia into ammonium (which cannot be absorbed) and increasing stool frequency to flush out toxins. The goal is typically 2-3 soft bowel movements daily.
    • Rifaximin:
      This non-absorbable antibiotic kills the ammonia-producing bacteria in the intestines. It is usually added if Lactulose alone is insufficient.
    • Nutritional Optimization:
      Avoiding constipation and maintaining adequate protein intake (from vegetable or dairy sources) is crucial.

Hepatocellular Carcinoma (HCC) Surveillance

Cirrhosis
  • Cirrhosis is the primary risk factor for primary liver cancer.

    • Screening Protocol:
      All patients with cirrhosis must undergo a liver ultrasound every 6 months, with or without a serum Alpha-Fetoprotein (AFP) test. Early detection allows for curative treatments like ablation or resection.

Liver Transplantation

  • The Curative Option:
    For patients with decompensated cirrhosis (Child-Pugh C) or localized liver cancer, liver transplantation is the definitive treatment.
  • Evaluation:
    A rigorous medical and psychosocial evaluation determines eligibility.
  • Living vs. Deceased Donor:
    Transplantation can be performed using a whole liver from a deceased donor or a partial liver from a healthy living donor. Successful transplant restores normal liver function and cures the portal hypertension.

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FREQUENTLY ASKED QUESTIONS

Is a low-protein diet necessary for cirrhosis?

No, this is an outdated belief. Patients with cirrhosis actually have higher protein needs because their muscles are wasting away. A high-protein diet is recommended, though vegetable-based proteins may be better tolerated in patients with severe encephalopathy.

TIPS stands for Transjugular Intrahepatic Portosystemic Shunt. It is a non-surgical procedure where a radiologist places a metal stent inside the liver to create a tunnel for blood to flow through, bypassing the scar tissue and lowering pressure.

In cirrhosis, Lactulose is used as a medicine, not just for constipation. Its job is to trap ammonia (a brain toxin) in your gut and flush it out of your body. You must take it to have 2-3 bowel movements a day to protect your brain.

This is a medical emergency. Symptoms include vomiting blood or passing black, tarry stools. You must go to the emergency room immediately for resuscitation, drugs to stop bleeding, and endoscopy to band the veins.

It is a major, complex surgery with significant risks, but it is also a life-saving procedure with excellent outcomes. The 1-year survival rate is generally over 90%, and it offers the chance for a return to a normal quality of life.

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