Sjögren’s Syndrome: Systemic Autoimmune Exocrinopathy, Lymphocytic Glandular Infiltration, and Sicca-Associated Metabolic Dysfunction

Learn about Sjögren’s syndrome, a chronic autoimmune disorder affecting moisture-producing glands. Understand its clinical definition and systemic impact today.

We're Here to Help.
Get in Touch.

Send us all your questions or requests, and our expert team will assist you.

Doctors
GDPR

Overview and Definition

What is Sjögren’s Syndrome?

If you are asking what is sjogren’s syndrome, it is a chronic autoimmune disorder characterized by the immune system attacking the body’s moisture-producing glands. While it can affect any part of the body, it primarily targets the lacrimal glands (which produce tears) and the salivary glands (which produce saliva). This results in the hallmark symptoms of severe dry eyes and a dry mouth.

Primary vs. Secondary Disease

Sjögren’s syndrome disease can occur in two ways. “Primary” Sjögren’s occurs by itself without another health condition. “Secondary” Sjögren’s develops alongside another autoimmune disease, such as rheumatoid arthritis or systemic lupus erythematosus. For medical coding and insurance documentation, the sjogren’s syndrome icd 10 code is M35.0, which covers the various manifestations of sicca (dryness) syndrome.

Symptoms and Immune Disorders

Icon LIV Hospital

Recognizing the Dryness

image 2 29 LIV Hospital

The most common symptoms of Sjögren’s syndrome involve the eyes and mouth. Patients often describe a sensation of having “sand or grit” in their eyes, along with persistent burning or redness. Dry mouth can lead to difficulty swallowing, a change in the sense of taste, and a rapid increase in dental cavities due to the lack of protective saliva.

Icon 1 LIV Hospital

Beyond the Glands

IMMUNOLOGY

While dryness is the most frequent complaint, the disease can have systemic effects. Many patients experience extreme fatigue, joint pain, and muscle stiffness. In more severe cases, the inflammation can affect the kidneys, lungs, liver, and nerves. There is also a small but significant increase in the risk of developing lymphoma (cancer of the lymph nodes) in people with this condition.

Diagnosis and Evaluation

The Diagnostic Process

A formal sjogren’s syndrome diagnosis is often a multi-step journey because the symptoms can mimic those caused by medications or other diseases. Doctors utilize a combination of clinical exams and laboratory tests to confirm the condition.

Clinical and Laboratory Tools

Common tools for evaluation include:

  • Schirmer Tear Test: A small strip of filter paper is placed under the lower eyelid to measure tear production.
  • Salivary Flow Test: Measuring the amount of saliva produced over a set period.
  • Blood Tests: Looking for specific markers like Anti-SSA (Ro) and Anti-SSB (La) antibodies, which are common in patients.
  • Lip Biopsy: A surgeon removes a tiny piece of a minor salivary gland from the inside of the lower lip to look for clusters of white blood cells (lymphocytes) that indicate the disease.
Sjögren syndrome

Treatment and Management

Sjogren's Syndrome and Treatment

Currently, there is no cure, so sjogren’s syndrome and treatment strategies focus on managing symptoms and preventing complications. The approach is typically “top-down,” starting with local relief and moving to systemic medications if the internal organs are involved.

Common Medical Interventions

Treatment for sjogren’s syndrome disease includes:

  • Moisture Replacement: Prescribing artificial tears and saliva substitutes to provide temporary relief.
  • Stimulating Secretion: Medications that signal the glands to produce more natural moisture.
  • Immunosuppressants: Drugs like hydroxychloroquine or methotrexate may be used to reduce joint pain and systemic inflammation.
  • Punctal Plugs: Tiny devices inserted into the tear ducts to keep natural tears on the eye longer.

Care and Prevention

Long-Term Management

Managing Sjögren’s syndrome requires a proactive approach to prevent permanent damage. Because the mouth is dry, patients must maintain meticulous oral hygiene and have frequent dental checkups to prevent tooth loss. Eye health must also be monitored closely by an ophthalmologist to prevent corneal scarring or infections.

Lifestyle Adjustments

While the autoimmune response cannot be prevented, patients can improve their quality of life by:

  • Increasing fluid intake and using sugar-free gum to stimulate saliva.
  • Avoiding dry environments (using a humidifier at home).
  • Protecting the eyes from wind and dry air with wrap-around sunglasses.
  • Avoiding medications that increase dryness, such as certain antihistamines or antidepressants, whenever possible.

30 Years of
Excellence

Trusted Worldwide

With patients from across the globe, we bring over three decades of medical

Book a Free Certified Online
Doctor Consultation

Clinics/branches
GDPR
Assoc. Prof. MD. Engin Aynacı Assoc. Prof. MD. Engin Aynacı Immunology Overview and Definition
Group 346 LIV Hospital

Reviews from 9,651

4,9

Was this article helpful?

Was this article helpful?

We're Here to Help.
Get in Touch.

Send us all your questions or requests, and our expert team will assist you.

Doctors
GDPR

FREQUENTLY ASKED QUESTIONS

What is the leading cause of Sjögren syndrome?

It is an autoimmune reaction where immune cells attack moisture-producing glands, likely triggered by a combination of genetics and environmental factors like viruses.

No, it is actually quite common, ranking as the second or third most common rheumatic autoimmune disorder, though it is frequently undiagnosed.

Hormonal differences, particularly the effects of estrogen and genetics related to the X chromosome, are believed to make women more susceptible.

It is rarely fatal directly. However, complications like lung fibrosis or lymphoma can be life-threatening, requiring careful monitoring.

Dry eyes can be caused by screens, aging, or weather. Sjögren syndrome is a systemic inflammatory disease where dry eyes are just one symptom of widespread immune dysfunction.

Spine Hospital of Louisiana
Need Help? Chat with our medical team

Let's Talk on WhatsApp

📌

Get instant answers from our medical team. No forms, no waiting — just tap below to start chatting now.

or call us at +90 530 510 71 24

How helpful was it?

helpful
GDPR
helpful
GDPR
helpful
GDPR