Infectious Diseases and Clinical Microbiology

Infectious Diseases: Diagnosis, Treatment & Travel Medicine

Infectious diseases specialists diagnose and treat infections from bacteria, viruses, fungi, and parasites, focusing on fevers, antibiotics, and vaccines.

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Clinical Manifestations and Vectors of Viral Propagation

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HIV can show up in many different ways, often in stages that match how the virus affects the immune system over time. The virus can be present for years without obvious symptoms, slowly causing damage. How HIV spreads is also complex, depending on certain body fluids and risky behaviors. At Liv Hospital, doctors pay attention to both the early signs that are easy to miss and the subtle symptoms that show up later as the immune system weakens.

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Acute Retroviral Syndrome (Primary Infection)

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The initial phase of infection, known as acute retroviral syndrome or seroconversion illness, typically occurs two to four weeks after exposure. During this period, the virus replicates exponentially, leading to a massive spike in viral load and a temporary drop in CD4 cells. The body mounts an aggressive immune response, resulting in flu-like symptoms. However, these symptoms are often nonspecific and can easily be mistaken for common viral illnesses such as influenza or mononucleosis.

  • Systemic Indicators: Fever is the most common sign, often accompanied by profound fatigue, malaise, and swollen lymph nodes (lymphadenopathy), particularly in the neck, armpits, and groin.
  • Dermatological Signs: A diffuse, red, non-pruritic (non-itchy) rash may appear on the trunk and face.
  • Oropharyngeal Symptoms: Severe sore throat and oral or esophageal mucosal ulcers are frequently reported.
  • Neurological and Muscular Symptoms: Patients may experience headache, myalgia (muscle pain), and arthralgia (joint pain).

This early phase is when a person is most likely to spread HIV because there is a lot of virus in their body fluids. However, it often goes undiagnosed because the symptoms go away on their own after a few weeks as the immune system starts to recover.

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Clinical Latency (Chronic HIV Infection)

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After the early phase, HIV enters a stage called clinical latency. This stage can last ten years or more without treatment. During this time, the virus keeps reproducing at low levels, and the person may not have any symptoms.

  • Asymptomatic Progression: The patient may feel entirely healthy, showing no outward signs of disease. However, the virus remains active, slowly destroying CD4 cells and damaging the immune architecture.
  • Subtle Warning Signs: As the latency period progresses and the immune system weakens, mild symptoms may emerge. These include persistent swelling of lymph nodes (generalized lymphadenopathy), unintentional weight loss, recurrent oral yeast infections (thrush), shingles (herpes zoster), and seborrheic dermatitis.
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Symptomatic HIV and Advanced Disease

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If left untreated, the immune system eventually deteriorates to a point where it can no longer control common pathogens. This leads to the development of symptomatic HIV infection and eventually AIDS.

  • Constitutional Symptoms: Chronic diarrhea lasting more than a month, recurring fevers, and drenching night sweats are common.
  • Opportunistic Infections: The hallmark of advanced disease is the emergence of infections that do not typically harm healthy people. These include Pneumocystis jirovecii pneumonia (PCP), toxoplasmosis of the brain, cytomegalovirus (CMV) retinitis, and esophageal candidiasis.
  • Malignancies: The loss of immune surveillance increases the risk of virus-associated cancers such as Kaposi’s sarcoma (presenting as purple skin lesions), invasive cervical cancer, and non-Hodgkin lymphoma.

Modes of Transmission

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Knowing how HIV spreads is important for prevention and understanding risk. HIV can only be passed on through certain body fluids: blood, semen, pre-seminal fluid, rectal fluids, vaginal fluids, and breast milk. For infection to happen, these fluids must touch a mucous membrane (like in the rectum, vagina, mouth, or tip of the penis), damaged skin, or enter the bloodstream directly.

  • Sexual Transmission: Unprotected anal or vaginal intercourse is the predominant mode of transmission globally. The risk is modulated by the viral load of the infected partner and the presence of other sexually transmitted infections (STIs), which can cause mucosal inflammation or ulceration, facilitating viral entry.
  • Parenteral Transmission: Sharing contaminated needles, syringes, or other drug injection equipment is a high-efficiency transmission route. Percutaneous needle-stick injuries in healthcare settings also pose a risk, though this is significantly lower.
  • Vertical Transmission: Transmission from mother to child can occur during pregnancy, childbirth, or breastfeeding. However, with modern medical interventions, this risk has been virtually eliminated in settings with access to comprehensive prenatal care.

Factors Influencing Transmissibility

The risk of passing on HIV is not always the same. It depends on different biological factors.

  • Viral Load: The amount of virus in the body fluid is the most critical predictor of transmission. Individuals with an undetectable viral load, achieved through successful treatment, cannot transmit the virus sexually.
  • Mucosal Integrity: The health of the mucosal barriers plays a role. A healthy, intact mucosa provides a barrier, whereas inflammation, tears, or ulcers increase the likelihood of viral entry.
  • Genetic Susceptibility: Certain genetic factors, such as the presence of specific HLA alleles or mutations in the CCR5 co-receptor, can influence an individual’s susceptibility to infection or the rate of disease progression.

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FREQUENTLY ASKED QUESTIONS

What are the earliest signs of an HIV infection?

The earliest signs usually appear 2 to 4 weeks after exposure and resemble a severe case of the flu. Symptoms include fever, swollen lymph nodes, sore throat, fatigue, muscle aches, and a rash. These symptoms are part of the body’s initial immune response, known as seroconversion. Still, they typically resolve on their own, leading to a period where the person feels healthy despite being infected.

No, HIV cannot be transmitted through saliva, sweat, tears, or urine. The virus does not survive well in these fluids and is not present in high enough quantities to cause infection. Transmission requires contact with specific fluids, such as blood, semen, vaginal fluids, rectal fluids, or breast milk, which must enter the body through mucous membranes or the bloodstream.

Yes, having another STI significantly increases the risk of acquiring HIV. STIs like syphilis, herpes, or gonorrhea can cause sores, breaks in the skin, or inflammation in the genital area. These breaches in the body’s natural barriers make it much easier for HIV to enter the bloodstream during sexual contact.

Viral load refers to the amount of HIV present in the blood. A high viral load means there is a lot of virus, making the person highly infectious. Conversely, if a person takes HIV medication daily and achieves an “undetectable” viral load, the amount of virus is so low that it cannot be transmitted to sexual partners. This concept is known as Undetectable = Untransmittable (U=U).

A person can live with chronic HIV infection for 10 to 15 years or even longer without showing any symptoms. This phase is called clinical latency. During this time, the virus remains active and continues to damage the immune system, and it can still be transmitted to others. This highlights the importance of regular testing, as feeling healthy does not guarantee the absence of infection.

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