Infectious Diseases and Clinical Microbiology

Infectious Diseases: Diagnosis, Treatment & Travel Medicine

Infectious diseases specialists diagnose and treat infections from bacteria, viruses, fungi, and parasites, focusing on fevers, antibiotics, and vaccines.

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Clinical Manifestations and Vector Dynamics

Lyme Disease

Lyme disease symptoms can vary widely, which makes it hard to diagnose. The disease can affect different parts of the body at different times. How the bacteria are transmitted depends on the feeding habits of the Ixodes tick. Knowing how the infection spreads and what symptoms to look for is important for early treatment and preventing long-term problems.

An Infectious Disease Specialist acts as a medical detective. They are consulted when an infection is difficult to diagnose, is accompanied by a high fever of unknown origin, does not respond to standard treatment, or involves a patient with a weakened immune system. Furthermore, this department plays a critical role in public health and hospital safety, managing infection control protocols to prevent the spread of resistant bacteria (superbugs) within healthcare settings.

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The Biology of Transmission

Lyme Disease

Lyme disease is not passed right away when a tick bites. The tick must stay attached for a while. The bacteria live in the tick’s gut and only become active when the tick starts feeding. They then move to the tick’s salivary glands, a process that usually takes 36 to 48 hours of feeding.

  • Tick Attachment and Engorgement
  • Ticks release saliva with chemicals that numb the skin, prevent clotting, and weaken the immune response. This lets them feed without being noticed and helps the bacteria enter the body. If you remove a tick within 24 hours, the risk of infection is very low, but the risk goes up the longer the tick stays attached.
  • Inoculation and Dissemination
  • Once the spirochetes reach the salivary glands, they are injected into the host’s dermis. From this focal point, the bacteria multiply and migrate centrifugally through the skin, creating the characteristic rash. If the immune system fails to contain the infection locally, the bacteria utilize the bloodstream and lymphatic system to disseminate to distant organs, including the heart, joints, and nervous system.
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Early Localized Symptoms

Lyme Disease

The hallmark of the early localized stage is the Erythema Migrans (EM) rash. While classically described as a “bull’s-eye” rash, clinical reality is more diverse.

Erythema Migrans Characteristics

  • The rash usually shows up 3 to 30 days after a tick bite. It starts as a small red spot and grows over time. Sometimes it looks like a target, but often it is just a solid red or oval patch. The rash usually does not hurt but may feel warm. Many people never notice a rash, so doctors also look for other signs.
  • Constitutional Symptoms
  • Along with or instead of a rash, people often feel like they have the flu. Common symptoms are tiredness, chills, fever, headache, stiff neck, muscle aches, and joint pain. These symptoms show the body is reacting to the infection.
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Early Disseminated Symptoms

Lyme Disease

If Lyme disease is not treated, the bacteria can spread and cause more serious problems in different organs weeks or months after the bite.

  • Multiple Erythema Migrans
  • If several new ring-shaped rashes appear far from the original bite, it means the bacteria have spread through the bloodstream.
  • Neuroborreliosis
  • The nervous system is often affected early. Symptoms can include severe headache and stiff neck (meningitis), facial weakness (Bell’s palsy, sometimes on both sides), and shooting pains, numbness, or tingling in the arms or legs.
  • Lyme Carditis
  • The bacteria can reach the heart and disrupt its electrical signals. This can cause heart block, which may range from mild to severe. People may feel their heart racing, get dizzy, have trouble breathing, or even faint.

Late Disseminated Symptoms

If not treated, some people develop long-term symptoms months or years after being bitten.

  • Lyme Arthritis
  • The most common late symptom, especially in North America, is joint swelling and pain, usually in large joints like the knee. The arthritis often affects one or a few joints and can cause a lot of swelling, sometimes more than the pain would suggest.
  • Late Neuroborreliosis
  • Long-term nerve problems can cause trouble with memory, focus, and thinking clearly (often called brain fog). Some people also have ongoing numbness, tingling, or pain in their arms or legs.
Lyme Disease

Atypical and Strain-Specific Presentations

Symptoms can differ depending on the type of Borrelia bacteria. In Europe, some strains are more likely to cause nerve problems, while in North America, joint pain is more common. Borrelia mayonii, a newer strain, can cause unusual symptoms like nausea, vomiting, and widespread rashes instead of the typical single rash.

Factors Influencing Symptom Severity

  • How severe the symptoms are can depend on a person’s genes and the type of bacteria. Some people are more likely to have joint problems that don’t go away with antibiotics because their immune system reacts strongly. Being infected with other tick-borne diseases at the same time can also make symptoms worse and last longer, often causing high fevers and blood problems

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FREQUENTLY ASKED QUESTIONS

What does the Lyme disease rash typically look like

The classic Lyme disease rash, known as Erythema Migrans, often resembles a bull’s-eye target, with a red center surrounded by a clear ring and an outer red ring. However, many rashes do not follow this pattern and may appear as a solid, expanding red or pink oval. It is usually flat, warm to the touch, and develops over several days, rarely causing itching or pain.

Yes, a significant percentage of patients diagnosed with Lyme disease do not recall having a rash. Estimates vary, but some studies suggest that 20% to 30% of patients may not develop or notice the Erythema Migrans rash. Therefore, the absence of a rash does not rule out Lyme disease if other symptoms and risk factors are present.

In general, a tick must be attached for at least 36 to 48 hours to transmit the Lyme disease bacterium effectively. The bacteria reside in the tick’s gut and require time to multiply and migrate to the salivary glands once feeding begins. Prompt removal of ticks within 24 hours of attachment significantly reduces the risk of infection.

Lyme carditis occurs when the bacteria enter the heart tissue and interfere with electrical signals. The most common symptom is heart block, which can cause the heart to beat too slowly or irregularly. Patients may experience lightheadedness, fainting, shortness of breath, palpitations, or chest pain. It is a serious complication that requires immediate medical attention.

If left untreated, Lyme disease can cause chronic arthritis, particularly in the knees. While the inflammation can be severe and recurrent, it typically does not cause the same level of permanent bone destruction seen in rheumatoid arthritis. However, long-standing untreated inflammation can damage the cartilage and surrounding tissues, leading to lasting joint dysfunction in some cases.

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