What is Urology?

Urology: Urinary & Reproductive Disease Diagnosis & Treatment

Urology treats urinary tract diseases in all genders and male reproductive issues, covering the kidneys, bladder, prostate, urethra, from infections to complex cancers.

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Clinical Manifestations: The Duality of Presentation

Urinary Retention

The symptoms of urinary retention vary depending on whether the condition is Acute or Chronic. Understanding this duality is critical for early recognition and appropriate triage. The presentation depends on whether the sensory nerves of the bladder are intact and whether the bladder wall has had time to adapt (stretch) to the increasing volume.

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Symptoms of Acute Urinary Retention (The Crisis)

The presentation is dramatic, distressing, and unmistakable. It is one of the most painful conditions in medicine.

  • Suprapubic Pain: Severe, agonizing pain in the lower abdomen. Patients often describe it as the worst pain of their life, comparable to kidney stones or childbirth. The pain is constant but may have waves of spasm as the bladder tries futilely to contract against the blockage.
  • Palpable Mass (Globus Vesicalis): The bladder can be felt (and often seen in thin patients) as a firm, tender, dome-shaped mass rising out of the pelvis, sometimes reaching the umbilicus (belly button). Percussion over this mass produces a dull sound distinct from the hollow sound of the bowel.
  • Urgency: An intense, desperate, and primitive desire to urinate that consumes the patient’s entire focus.
  • Anuria or Strangury: Complete absence of urine flow despite intense straining. Sometimes, the patient may squeeze out a few drops of urine (strangury) due to extreme abdominal pressure, but the bladder does not empty.
  • Vegetative Symptoms: Profuse sweating (diaphoresis), tachycardia (rapid heart rate), anxiety, restlessness, nausea, and hypertension due to severe pain distress. This physiological stress response can be dangerous in patients with pre-existing heart conditions.
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Symptoms of Chronic Urinary Retention (The Silent Threat)

Urinary Retention

The presentation is insidious, often developing slowly over years. Patients frequently adapt to their symptoms and may not report them until complications arise.

  • Painless Abdominal Distension: The bladder may contain 1-2 liters of urine, but the patient feels no pain because the sensory nerves have been stretched and desensitized over time (accommodation and sensory downregulation).
  • LUTS (Lower Urinary Tract Symptoms):
    • Hesitancy: A long delay (of seconds or minutes) before the stream starts. The patient often has to “wait for the muscle to catch up.”
    • Weak Stream: A flow that lacks force and projection, often just a vertical dribble that falls on the shoes.
    • Intermittency: The stream stops and starts multiple times during a single void as the abdominal muscles fatigue or the obstruction shifts.
    • Straining: Needing to push with abdominal muscles (Valsalva maneuver) to maintain flow.
  • Overflow Incontinence: Constant dribbling of urine or wetness in underwear. This occurs because the intra-vesical pressure constantly exceeds the sphincter pressure, causing “spillover.” Patients often mistake this for stress incontinence or an overactive bladder.
  • Nocturnal Enuresis: Bedwetting in adults. This is a significant “red flag” for severe chronic retention; as the sphincter relaxes during deep sleep, the overfull bladder leaks.
  • Recurrent UTIs: Stagnant urine creates a swampy environment for bacteria. Frequent, hard-to-treat infections are often the only sign of retention in elderly patients.
  • Constitutional Symptoms: In advanced cases where the kidneys are affected, patients may present with lethargy, nausea, vomiting, confusion, and edema (signs of Uremia/Renal Failure).

Risk Factors and Etiology: The "Pipe," "Pump," and "Wiring"

Urinary Retention

Urinary retention is rarely idiopathic; it is almost always secondary to another pathological process involving obstruction, muscle failure, or nerve damage.

Obstructive Risk Factors (The “Pipe” Problem)

  • Benign Prostatic Hyperplasia (BPH): The most common cause in men over 50. The prostate gland enlarges and compresses the prostatic urethra, increasing outflow resistance.
  • Urethral Stricture: Scar tissue narrowing the urethra caused by previous trauma (straddle injury, pelvic fracture), infection (Gonorrhea, Lichen Sclerosus), or instrumentation (catheterization).
  • Meatal Stenosis: Narrowing of the external opening of the penis, often due to chronic inflammation (Balanitis Xerotica Obliterans) or prior circumcision issues.
  • Phimosis: An extremely tight, non-retractile foreskin that obstructs the meatus (pinhole opening), causing ballooning of the foreskin during voiding.
  • Prostate Cancer: Advanced cancer can infiltrate and rigidify the bladder neck, preventing it from funneling open.
  • Pelvic Organ Prolapse (Women): A severe cystocele (bladder drop) or uterine prolapse can “kink” the urethra, obstructing flow.
  • Fecal Impaction: A massive stool burden in the rectum compresses the urethra anteriorly.

Neurological Risk Factors (The "Wiring" Problem)

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  • Spinal Cord Injury: Injuries above the sacral level lead to Detrusor-Sphincter Dyssynergia (incoordination). Injuries at the sacral level (S2-S4) lead to an acontractile (flaccid) bladder.
  • Diabetes Mellitus: “Diabetic Cystopathy” is a progressive sensory and motor neuropathy. The bladder loses sensation of filling, becomes chronically overdistended, and eventually loses contractility.
  • Multiple Sclerosis (MS): Demyelinating plaques in the spinal cord disrupt the signals for bladder emptying and coordination.
  • Cauda Equina Syndrome: Compression of the sacral nerve roots by a herniated disc causes sudden, painless retention and saddle anesthesia. This is a surgical emergency.
  • Stroke: Often leads to retention in the acute “cerebral shock” phase.

Pharmacological Risk Factors (The "Chemical" Problem)

Many common medications inhibit bladder function or increase outlet resistance.

    • Anticholinergics: Drugs used for allergies (Diphenhydramine), depression (Tricyclics like Amitriptyline), IBS (Hyoscyamine), or COPD (Ipratropium). These block the acetylcholine needed for bladder contraction.
    • Sympathomimetics: Decongestants (Pseudoephedrine, Phenylephrine) found in cold medicines. These stimulate Alpha-1 receptors, tightening the bladder neck sphincter.
    • Opioids: Painkillers decrease the sensation of fullness and inhibit the voiding reflex centrally in the brainstem.
    • Anesthesia: General and spinal anesthesia temporarily paralyze the bladder (Post-Operative Urinary Retention – POUR).

Special Populations: Women and Fowler's Syndrome

While rare, retention in young women can be caused by Fowler’s Syndrome. This is a condition of the external urethral sphincter, often associated with Polycystic Ovary Syndrome (PCOS). The sphincter fails to relax due to abnormal electromyographic (EMG) activity (decelerating bursts), effectively locking the bladder closed. It is non-obstructive in a mechanical sense but functional.

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FREQUENTLY ASKED QUESTIONS

Why does my stream stop and start?

This is called “intermittency.” It usually indicates that the bladder muscle (detrusor) is struggling to overcome an obstruction (like an enlarged prostate). The muscle pushes, gets exhausted, stops to rest for a second (to recover ATP), and goes again. It is a sign of a decompensating bladder that is losing its reserve power.

Yes. This is the paradox of “Overflow.” Because your bladder is full (e.g., holding 1000 mL), there is no room for new urine from the kidneys. So, every time the kidneys secrete 50 mL, 50 mL spills out. You feel like you are peeing constantly, but you are never actually emptying the tank. This is a dangerous state often mistaken for incontinence.

Cold and flu medicines often contain decongestants like pseudoephedrine. This drug works by constricting blood vessels in the nose to stop a runny nose. However, it also strongly stimulates the Alpha-1 receptors on the smooth muscle sphincter at the neck of the bladder. If you already have a slightly enlarged prostate, this extra tightening can be enough to block the urine flow completely.

It can be. Rapid emptying of a chronically distended bladder (e.g., after putting in a catheter) can cause “Decompression Hematuria” because the blood vessels in the bladder wall burst when the pressure drops suddenly. However, spontaneous blood in the urine (hematuria) should always be investigated to rule out bladder cancer, stones, or infection.

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