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Urology: Urinary & Reproductive Disease Diagnosis & Treatment

Urology treats urinary tract diseases in all genders and male reproductive issues, covering the kidneys, bladder, prostate, urethra, from infections to complex cancers.

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Clinical Manifestations: The Symptom Triad

Clinical Manifestations: The Symptom Triad

The clinical presentation of uterine fibroids is highly variable. Approximately 50% of women are asymptomatic, with the condition discovered incidentally during routine pelvic exams or imaging. For symptomatic women, the manifestations are debilitating and are classified into three primary categories: Abnormal Uterine Bleeding, Bulk/Pressure Symptoms, and Reproductive Dysfunction.

  1. Abnormal Uterine Bleeding (AUB-L)

This is the most frequent indication for medical or surgical intervention. In the FIGO classification of bleeding, this is termed AUB-L (Leiomyoma).

  • Menorrhagia (Heavy Menstrual Bleeding): Defined as prolonged (>7 days) or heavy menstrual bleeding (>80mL per cycle). The mechanisms by which fibroids cause bleeding are complex:
    • Surface Area: Fibroids distend the uterine cavity, increasing the total surface area of the endometrium that sheds during menstruation.
    • Vascular Abnormalities: Fibroids induce angiogenesis (the formation of new blood vessels). The venules overlying a submucosal fibroid are often dilated, fragile, and lack the normal vasoconstrictive ability.
    • Contractility Interference: Normal menstruation cessation relies on the myometrium contracting to compress the spiral arteries. Intramural fibroids disrupt this muscular architecture, preventing adequate hemostasis.
  • Iron Deficiency Anemia: Chronic heavy blood loss depletes iron stores (ferritin), leading to systemic anemia. Patients present with chronic fatigue, dyspnea (shortness of breath), palpitations, pica (craving ice or dirt), hair loss, and pallor. Severe anemia (Hemoglobin <7 g/dL) can lead to high-output heart failure if untreated.
  • Dysmenorrhea: Severe cramping caused by the uterus trying to expel the fibroid or large clots.
  • Intermenstrual Bleeding: Spotting or bleeding between periods is less common but can occur, particularly with submucosal fibroids that ulcerate the overlying endometrial lining
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Risk Factors

Risk Factors

Understanding risk factors aids in early detection and lifestyle modification.

  • Nulliparity: Women who have never given birth have a higher risk compared to multiparous women. Pregnancy provides a “break” from cyclical estrogen exposure and involves uterine remodeling (involution) that may clear micro-fibroids.
  • Early Menarche: Starting menstruation at a young age (<10 years) extends the lifetime window of exposure to ovarian steroids.
  • Obesity: Adipose tissue contains aromatase, which converts androgens to estrogens. This systemic hyper-estrogenic state fuels fibroid growth. Every 10kg of weight gain increases fibroid risk by approximately 21%.
  • Diet: Diets high in red meat (beef, ham) are associated with a higher incidence. Conversely, diets rich in green vegetables, fruit, and dairy appear protective.
  • Vitamin D Deficiency: Emerging research suggests a strong correlation between hypovitaminosis D and fibroid pathogenesis. Vitamin D acts as a tumor suppressor in myometrial cells; deficiency removes this brake on growth.
  • Alcohol Consumption: Alcohol intake, particularly beer, is associated with an increased risk, possibly by raising circulating hormone levels.

2. Bulk and Pressure Symptoms

As fibroids enlarge, they act as space-occupying lesions within the confined bony pelvis.

  • Pelvic Pain and Heaviness: Patients often describe a sensation of “bearing down,” fullness, or a palpable mass in the lower abdomen. Large fibroids can equate to the size of a 20-week pregnancy, causing visible abdominal distension (“fibroid belly”).
  • Urinary Symptoms: The uterus sits directly behind and superior to the bladder. Anterior fibroids (subserosal or intramural) can compress the bladder, reducing its functional capacity. This leads to urinary frequency (needing to void often), urgency, and nocturia (waking up at night to void). In rare cases, a fibroid at the bladder neck can cause urinary retention (inability to void), a medical emergency.
  • Ureteral Obstruction: Large lateral fibroids can compress the ureters against the pelvic brim. This silent obstruction causes hydronephrosis (swelling of the kidneys) and hydroureter, which can lead to renal impairment if left untreated.
  • Bowel Dysfunction: Posterior fibroids can compress the rectosigmoid colon against the sacrum. This mechanical obstruction leads to chronic constipation, tenesmus (a feeling of incomplete evacuation), ribbon-like stools, and bloating.
  • Dyspareunia: Deep pain during sexual intercourse can occur if fibroids are located near the cervix, in the posterior cul-de-sac, or if they render the uterus immobile.

Radiculopathy: Huge fibroids can compress the pelvic nerves (obturator or sciatic nerves), causing referred pain radiating to the lower back, buttocks, or legs.

3. Reproductive Dysfunction and Infertility

Fibroids are implicated in 2-3% of infertility cases and can complicate pregnancy.

  • Infertility: The impact depends heavily on location.
    • Submucosal Fibroids: These have the most substantial negative impact. They distort the cavity, impairing sperm transport and preventing embryo implantation. They also alter the local endometrial expression of HOXA10, a gene critical for endometrial receptivity.
    • Intramural Fibroids: Even without cavity distortion, large intramural fibroids can reduce fertility rates, likely due to altered uterine contractility and inflammatory cytokines.
    • Subserosal Fibroids: Generally have a negligible impact on conception.
  • Pregnancy Complications: Women with fibroids have higher risks of:
    • Spontaneous Abortion (Miscarriage): Increased risk in the first trimester.
    • Placental Abruption: The placenta may separate prematurely if it implants directly over a fibroid due to poor vascularization.
    • Fetal Malpresentation: Fibroids can distort the cavity, preventing the fetus from turning to the vertex (head-down) position and leading to a breech presentation.
    • Preterm Labor: Uterine over-distension can trigger early contractions.
    • Postpartum Hemorrhage: The fibroid-laden uterus may fail to contract (atony) after delivery.

Pain: Red degeneration causes severe localized pain, usually in the second trimester.

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FREQUENTLY ASKED QUESTIONS

Can fibroids cause back pain and sciatica?

Yes, large fibroids, particularly those located on the posterior aspect of the uterus, can exert pressure on the sacral plexus or the sciatic nerve roots. This compression causes referred pain that radiates to the lower back, glutes, and down the legs, mimicking musculoskeletal sciatica.

Fibroids increase the surface area of the uterine lining, create a chaotic and fragile vascular network (angiogenesis), and physically prevent the uterine muscle fibers from contracting tightly to seal off the spiral arteries at the end of menstruation, resulting in prolonged and heavy flow and the passage of clots.

While a direct causal link remains to be elucidated, epidemiological studies show a significant inverse relationship: women with low Vitamin D levels have a higher prevalence of fibroids. In vitro studies show that Vitamin D inhibits fibroid cell proliferation and ECM deposition, suggesting that deficiency may facilitate tumor growth.

Yes, in two ways. First, large fibroids can weigh several kilograms themselves (some reaching 5-10kg or more), directly adding to body mass. Second, the abdominal distension caused by the tumor (“fibroid belly”) can mimic visceral fat accumulation or pregnancy.

 Generally, fibroids cause pain during menstruation (dysmenorrhea) due to uterine cramping. However, large fibroids can cause a constant sensation of pelvic fullness or pressure that may be exacerbated during ovulation or the premenstrual phase due to transient hormonal fluid retention and pelvic congestion.

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