Pulmonology focuses on diagnosing and treating lung and airway conditions such as asthma, COPD, and pneumonia, as well as overall respiratory health.

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The Clinical History: The Foundation

The diagnosis of chronic bronchitis begins with a meticulous clinical history. The physician acts as a detective, establishing the temporal criteria for the disease: a productive cough for 3 months in 2 consecutive years. The history must probe deeply into exposure: calculating “pack-years” of smoking (packs per day multiplied by years smoked), identifying occupational exposures to dusts or fumes, and assessing indoor air quality (biomass fuel). A history of childhood respiratory infections or a family history of lung disease is crucial for identifying genetic risks. The clinician also evaluates the impact of symptoms on daily life using validated tools like the CAT (COPD Assessment Test) or the mMRC (Modified Medical Research Council) dyspnea scale. These tools quantify the symptom burden, which is essential for guiding treatment intensity.

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Physical Examination Signs

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While early disease may present with a routine exam, advanced chronic bronchitis has distinct physical signs.

  • Inspection: The patient may use accessory muscles (neck and shoulder muscles) to breathe. “Pursed-lip breathing” is a compensatory maneuver in which the patient exhales through pursed lips to create back-pressure and keep the airways open. In severe cases, the chest may appear barrel-shaped due to hyperinflation. Cyanosis (blue lips/fingernails) and peripheral edema (swollen ankles) suggest cor pulmonale.
  • Auscultation: The stethoscope reveals the turbulent airflow. “Rhonchi” are low-pitched, snoring sounds caused by secretions in large airways; they often change after coughing. “Wheezes” are high-pitched musical sounds indicating narrowing. Breath sounds may be distant or quiet if there is significant air trapping or emphysema.

Percussion: Hyper-resonance (a drum-like sound) upon tapping the chest indicates air trapping.

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Spirometry: The Gold Standard

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Spirometry is the non-invasive, confirmatory test for airflow limitation. It measures the volume of air a patient can exhale and the speed of exhalation.

  • FEV1 (Forced Expiratory Volume in 1 Second): The volume exhaled in the first second. This is the primary measure of airway patency.
  • FVC (Forced Vital Capacity): The total volume exhaled.
  • FEV1/FVC Ratio: This is the diagnostic number. A post-bronchodilator ratio of less than 0.70 confirms the presence of persistent airflow obstruction, the hallmark of COPD/chronic bronchitis.
  • Severity Grading (GOLD Stages): The FEV1 percentage of predicted (based on age, height, sex) determines severity: GOLD 1 (Mild, FEV1 > 80%), GOLD 2 (Moderate, 50-80%), GOLD 3 (Severe, 30-50%), and GOLD 4 (Very Severe, < 30%).
  • Reversibility Testing: The test is repeated after administering a bronchodilator (such as albuterol). If FEV1 improves significantly (>12% and > 200 mL), it suggests an asthmatic component (Asthma-COPD Overlap).

Arterial Blood Gas (ABG) Analysis

For patients with low pulse oximetry saturations (<92%) or severe FEV1 (<35%), an ABG is performed by drawing blood from an artery.

  • Hypoxemia (PaO2): Measures the severity of oxygenation failure. It determines the need for supplemental home oxygen.
  • Hypercapnia (PaCO2): Measures carbon dioxide retention. Chronic bronchitis patients are prone to retaining CO2 because they cannot exhale fully. Chronic respiratory acidosis with metabolic compensation (high bicarbonate) is a sign of chronic ventilatory failure.
  • pH: Assesses acute-on-chronic failure during exacerbations.

Radiological Imaging: CT and X-Ray

  • Chest X-Ray: This is a screening tool. In chronic bronchitis, it may show “increased bronchovascular markings” (dirty lungs) or cardiomegaly (enlarged heart). Its primary role is to rule out comorbidities like lung cancer, pneumonia, or heart failure.
  • High-Resolution CT (HRCT): This provides anatomical detail. It allows the clinician to quantify the extent of emphysema versus bronchial wall thickening. It can diagnose bronchiectasis (permanent airway dilation), which often co-exists and requires different management (airway clearance). It is also the standard for lung cancer screening in eligible smokers.

Alpha-1 Antitrypsin Screening

The World Health Organization recommends that every patient diagnosed with COPD/chronic bronchitis be screened once for Alpha-1 Antitrypsin Deficiency. This is done via a blood test measuring the level of the AAT protein. If levels are low, genetic phenotyping/genotyping is done. Identifying this is critical because it changes management (augmentation therapy is available) and requires family screening.

Sputum Analysis and Culture

Routine sputum culture is not done for stable patients. However, it is vital in specific scenarios:

  • Frequent Exacerbators: To identify chronic colonization with bacteria like Pseudomonas aeruginosa, which drives inflammation and requires targeted antibiotics.
  • Purulent Exacerbations: To guide antibiotic choice in acute flare-ups.
  • Eosinophil Count: Measuring sputum (or blood) eosinophils helps identify patients with “eosinophilic bronchitis” who respond well to inhaled corticosteroids.

Assessment of Comorbidities

Evaluating the “whole patient” is essential.

  • Echocardiogram: To screen for pulmonary hypertension and right heart failure (cor pulmonale) caused by chronic hypoxia.
  • DEXA Scan: To screen for osteoporosis, a common complication of smoking, inactivity, and steroid use.
  • Sleep Study: To rule out Obstructive Sleep Apnea (OSA). The “Overlap Syndrome” (COPD + OSA) carries a high mortality risk if untreated.

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Assoc. Prof. MD. Engin Aynacı Assoc. Prof. MD. Engin Aynacı Pulmonology Overview and Definition
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FREQUENTLY ASKED QUESTIONS

Why do I have to blow into the tube so hard?

Spirometry requires maximum effort to measure your lung capacity and the degree of obstruction accurately; a weak effort can yield false results, leading to incorrect treatment.

Yes, a CT scan can visualize the thickness of the airway walls and the destruction of air sacs (emphysema) in great detail, giving a clear picture of the structural damage.

Oxygen saturation (finger clip) estimates oxygen levels, while a blood gas (needle in wrist) precisely measures oxygen, carbon dioxide, and blood acidity, giving a complete picture of lung function.

Because Alpha-1 Antitrypsin Deficiency makes your lungs incredibly sensitive to smoke, having both the gene and the smoking history causes much more severe disease that may need special protein replacement therapy.

If you snore, have morning headaches, or are tired despite sleeping, you might have sleep apnea along with bronchitis; treating both is critical for your heart and oxygen levels.

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