Pulmonology focuses on diagnosing and treating lung and airway conditions such as asthma, COPD, and pneumonia, as well as overall respiratory health.

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Smoking Cessation: The Intervention of Choice

Smoking cessation is the single most effective, disease-modifying intervention for chronic bronchitis. It is the only measure proven to alter the natural history of the disease and slow the accelerated rate of lung function decline. At Liv Hospital, we treat tobacco dependence as a chronic, relapsing medical condition, not a lifestyle choice.

  • Pharmacotherapy: Varenicline (Chantix) and Bupropion (Zyban) block nicotine receptors or reduce cravings. Nicotine Replacement Therapy (NRT) provides clean nicotine to manage withdrawal without the toxins of smoke. Combination therapy (e.g., patch + gum) is most effective.
  • Behavioral Support: Cognitive Behavioral Therapy (CBT) helps patients identify triggers and develop coping mechanisms.
  • The “Teachable Moment”: Hospitalization for an exacerbation is a prime window for initiation, as patients are motivated and in a smoke-free environment.
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Bronchodilators: The Mainstay of Symptom Relief

PULMONOLOGY

Bronchodilators relax the smooth muscle tone of the airways, reducing hyperinflation and improving emptying.

  • Long-Acting Muscarinic Antagonists (LAMA): Drugs like Tiotropium or Umeclidinium block acetylcholine receptors. They are the foundation of therapy, proven to reduce exacerbation rates and hospitalizations more effectively than LABAs. They also decrease mucus secretion.
  • Long-Acting Beta-Agonists (LABA): Drugs like Salmeterol or Formoterol stimulate beta-2 receptors to relax airways.
  • Dual Bronchodilation (LAMA+LABA): Combining these two classes in a single inhaler provides superior bronchodilation and symptom relief compared to monotherapy and is the standard for symptomatic patients.
  • Short-Acting Bronchodilators (SABA/SAMA): Albuterol and Ipratropium are used as “rescue” medications for immediate relief of breakthrough dyspnea.
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Anti-Inflammatory Therapy: Inhaled Corticosteroids (ICS)

PULMONOLOGY

ICS use in chronic bronchitis is specific and targeted. Unlike in asthma, they are not for everyone. They are indicated for patients with a history of frequent exacerbations (≥2 per year or one leading to hospitalization) despite optimal bronchodilator therapy, or those with high blood eosinophil counts (>300 cells/µL).

  • Triple Therapy: The combination of ICS/LAMA/LABA in a single inhaler has been shown to reduce mortality and exacerbations in severe COPD.
  • Risk of Pneumonia: Long-term ICS use increases the risk of pneumonia, so the benefit must outweigh the risk.

Phosphodiesterase-4 (PDE4) Inhibitors

Roflumilast is a specialized oral anti-inflammatory drug targeting the PDE4 enzyme. It is specifically indicated for patients with severe COPD associated with chronic bronchitis (productive cough) and a history of frequent exacerbations. It works by reducing neutrophilic inflammation and has been shown to improve lung function and reduce flare-ups. However, side effects like nausea, diarrhea, and weight loss can limit its use.

Antibiotics: Acute and Chronic Use

  • Acute Exacerbations: Antibiotics are indicated for exacerbations characterized by the “Anthonisen cardinal signs”: increased dyspnea, increased sputum volume, and increased sputum purulence (pus). They shorten recovery time and reduce treatment failure.
  • Chronic Azithromycin: For patients who continue to have frequent exacerbations despite maximal inhaler therapy, long-term low-dose Azithromycin (e.g., 250mg three times a week) is used. It acts not just as an antibiotic but as an anti-inflammatory and immunomodulatory agent, reducing the frequency of flare-ups. Hearing and cardiac monitoring (QT interval) are required.

Mucolytics and Airway Clearance

Managing the “mucus load” is critical for symptom relief and infection prevention.

  • Pharmacologic Mucolytics: N-acetylcysteine (NAC) and Carbocisteine break down the disulfide bonds in mucus, reducing viscosity. High-dose NAC has antioxidant properties that may reduce exacerbations.
  • Device-Based Clearance: Oscillatory Positive Expiratory Pressure (OPEP) devices (like Acapella or Aerobika) create vibrations during exhalation that shear mucus off the bronchial walls, facilitating expectoration.

Active Cycle of Breathing: Specialized breathing techniques taught by physiotherapists help mobilize secretions from the deep lung to the central airways.

Pulmonary Rehabilitation

Pulmonary Rehabilitation is a comprehensive, multidisciplinary intervention that is as effective as medication. It breaks the “spiral of deconditioning,” in which dyspnea leads to inactivity, which leads to muscle weakness, which, in turn, worsens dyspnea.

  • Exercise Training: Supervised aerobic and resistance training retrains the muscles to use oxygen more efficiently, reducing the ventilatory demand on the lungs.
  • Education: Patients learn energy conservation techniques, breathing strategies, and self-management skills.
  • Psychosocial Support: Addressing the anxiety and depression that accompany chronic breathlessness.

Oxygen Therapy and Ventilation

  • Long-Term Oxygen Therapy (LTOT): For patients with severe resting hypoxemia (PaO2 < 55 mmHg), supplemental oxygen used for >15 hours/day is the only therapy (besides smoking cessation) proven to prolong survival. It reverses pulmonary vasoconstriction and prevents right heart failure.
  • Non-Invasive Ventilation (NIV): For patients with chronic hypercapnic respiratory failure (high CO2), home BiPAP can improve survival and reduce hospital admissions by resting the respiratory muscles and improving gas exchange at night.

Surgical and Interventional Therapies

  • Lung Volume Reduction: For select patients with severe emphysema and hyperinflation, removing the most damaged parts of the lung (via surgery or endobronchial valves) allows the remaining lung to function better.
  • Lung Transplantation: For young patients with end-stage disease and no other options, transplantation offers a chance at extended survival and improved quality of life.
  • Rheoplasty (Bronchial Rheoplasty): An emerging investigational therapy using non-thermal pulsed electric fields to ablate the hyperplastic mucus-producing cells in the airways, targeting the root cause of mucus hypersecretion.

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Assoc. Prof. MD. Engin Aynacı Assoc. Prof. MD. Engin Aynacı Pulmonology Overview and Definition
Group 346 LIV Hospital

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FREQUENTLY ASKED QUESTIONS

Why do I need to rinse my mouth after using my steroid inhaler?

Steroid residue left in the mouth can suppress the local immune system, allowing a fungal infection called thrush (candida) to grow; rinsing and spitting prevents this.

No, taking daily antibiotics (other than specific protocols like Azithromycin) breeds dangerous, drug-resistant bacteria that are much harder to treat when you do get sick.

It’s a vicious cycle where breathlessness makes you avoid activity, which makes your muscles weak, which makes you more breathless with even less activity. Pulmonary rehab breaks this cycle.

When you blow into it, it vibrates; these vibrations travel down into your lungs, shaking the mucus loose from the airway walls so you can cough it up more easily.

No, your body is already physiologically dependent on oxygen; the therapy provides what your damaged lungs can’t, protecting your heart and brain from further damage.

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